Advanced

Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study.

Engström, Gunnar LU ; Hedblad, Bo LU ; Janzon, Lars LU and Lindgärde, Folke LU (2005) In Diabetologia 48(Nov 11). p.2525-2531
Abstract
Aims/hypothesis: Mice that are deficient for complement factor 3 (C3) have shown resistance to weight gain, despite increased food intake. Cross-sectional studies of humans have reported correlations between C3 and obesity. This longitudinal study explored whether C3 predicts a large weight gain in middle-aged men. Methods: Plasma concentrations of C3 and complement factor 4 (C4) were measured in 2,706 non-diabetic healthy men aged between 38 and 50 years, who were re-examined after a mean period of 6.1 years. Results: After adjustments for initial weight, age, height and follow-up time, the odds of incurring large weight gain (75th percentile, >= 3.8 kg) were 1.00 (reference), 0.96 (95% CI:0.7-1.2), 1.1 (CI:0.9-1.5) and 1.4... (More)
Aims/hypothesis: Mice that are deficient for complement factor 3 (C3) have shown resistance to weight gain, despite increased food intake. Cross-sectional studies of humans have reported correlations between C3 and obesity. This longitudinal study explored whether C3 predicts a large weight gain in middle-aged men. Methods: Plasma concentrations of C3 and complement factor 4 (C4) were measured in 2,706 non-diabetic healthy men aged between 38 and 50 years, who were re-examined after a mean period of 6.1 years. Results: After adjustments for initial weight, age, height and follow-up time, the odds of incurring large weight gain (75th percentile, >= 3.8 kg) were 1.00 (reference), 0.96 (95% CI:0.7-1.2), 1.1 (CI:0.9-1.5) and 1.4 (CI:1.1-1.8), respectively, among men with C3 levels in the first, second, third and fourth quartiles (p for trend=0.01) respectively. This relationship remained significant after further adjustments for lifestyle factors (physical inactivity, alcohol, smoking), metabolic factors (glucose or homeostasis model assessment values, cholesterol, triglycerides), inflammatory markers (fibrinogen, haptoglobin, ceruloplasmin, orosomucoid, alpha 1-antitrypsin) and for C4. C4 was associated with weight gain after adjustments for initial weight, height, follow-up time and lifestyle factors, but not after adjustments for C3. Conclusions/interpretation: C3 is a risk factor for incurring large weight gain in middle-aged men. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
complement, obesity, epidemiology
in
Diabetologia
volume
48
issue
Nov 11
pages
2525 - 2531
publisher
Springer Verlag
external identifiers
  • wos:000233721600014
  • pmid:16283247
  • scopus:28444485343
ISSN
1432-0428
DOI
10.1007/s00125-005-0021-6
language
English
LU publication?
yes
id
19ee69d4-9c84-4db3-8587-6477dedb3fa1 (old id 148005)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16283247&dopt=Abstract
date added to LUP
2007-07-18 14:03:47
date last changed
2017-02-26 03:32:31
@article{19ee69d4-9c84-4db3-8587-6477dedb3fa1,
  abstract     = {Aims/hypothesis: Mice that are deficient for complement factor 3 (C3) have shown resistance to weight gain, despite increased food intake. Cross-sectional studies of humans have reported correlations between C3 and obesity. This longitudinal study explored whether C3 predicts a large weight gain in middle-aged men. Methods: Plasma concentrations of C3 and complement factor 4 (C4) were measured in 2,706 non-diabetic healthy men aged between 38 and 50 years, who were re-examined after a mean period of 6.1 years. Results: After adjustments for initial weight, age, height and follow-up time, the odds of incurring large weight gain (75th percentile, >= 3.8 kg) were 1.00 (reference), 0.96 (95% CI:0.7-1.2), 1.1 (CI:0.9-1.5) and 1.4 (CI:1.1-1.8), respectively, among men with C3 levels in the first, second, third and fourth quartiles (p for trend=0.01) respectively. This relationship remained significant after further adjustments for lifestyle factors (physical inactivity, alcohol, smoking), metabolic factors (glucose or homeostasis model assessment values, cholesterol, triglycerides), inflammatory markers (fibrinogen, haptoglobin, ceruloplasmin, orosomucoid, alpha 1-antitrypsin) and for C4. C4 was associated with weight gain after adjustments for initial weight, height, follow-up time and lifestyle factors, but not after adjustments for C3. Conclusions/interpretation: C3 is a risk factor for incurring large weight gain in middle-aged men.},
  author       = {Engström, Gunnar and Hedblad, Bo and Janzon, Lars and Lindgärde, Folke},
  issn         = {1432-0428},
  keyword      = {complement,obesity,epidemiology},
  language     = {eng},
  number       = {Nov 11},
  pages        = {2525--2531},
  publisher    = {Springer Verlag},
  series       = {Diabetologia},
  title        = {Weight gain in relation to plasma levels of complement factor 3: results from a population-based cohort study.},
  url          = {http://dx.doi.org/10.1007/s00125-005-0021-6},
  volume       = {48},
  year         = {2005},
}