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Dipping and variability of blood pressure and heart rate at night are heritable traits.

Fava, Cristiano LU ; Burri, Philippe LU ; Almgren, Peter LU ; Arcaro, Guido; Groop, Leif LU ; Hulthén, Lennart LU and Melander, Olle LU (2005) 20th Annual Meeting of the American-Society-of-Hypertension In American Journal of Hypertension 18(11). p.1402-1407
Abstract
Background: Blunted nocturnal blood pressure dipping (NBPD) as well as high variability in blood pressure (BPV) and low variability in heart rate (HRV), are associated with increased cardiovascular morbidity and mortality. The aim of this study was to determine whether these traits are heritable. Methods: We studied 260 healthy siblings without antihypertensive drugs from 118 Swedish families. The BPV and HRV were defined as the standard deviation of BP and heart rate values recorded during 24 h, daytime (6 AM to 10 Pm), and night-time (10 Pm to 6 AM). The NBPD was defined as the ratio between night-time and daytime BP. Heritability was estimated with a maximal likelihood method implemented in the Solar software package with and without... (More)
Background: Blunted nocturnal blood pressure dipping (NBPD) as well as high variability in blood pressure (BPV) and low variability in heart rate (HRV), are associated with increased cardiovascular morbidity and mortality. The aim of this study was to determine whether these traits are heritable. Methods: We studied 260 healthy siblings without antihypertensive drugs from 118 Swedish families. The BPV and HRV were defined as the standard deviation of BP and heart rate values recorded during 24 h, daytime (6 AM to 10 Pm), and night-time (10 Pm to 6 AM). The NBPD was defined as the ratio between night-time and daytime BP. Heritability was estimated with a maximal likelihood method implemented in the Solar software package with and without adjustment for significant covariates. Results: At night, significant heritability was found for systolic (33%, P <.05), diastolic (36%, P <.05), and mean (42%, P <.01) BPV. After covariate adjustment the corresponding heritability values were 23% (P =.08), 29% (P <.05), and 37% (P <.05). Daytime BPV was not heritable. The heritability of NBPD was 38% (P <.05) for systolic, 9% (P =.29) for diastolic, and 36% (P <.05) for mean BP, but after adjustment only systolic NBPD was significant (29%, P <.05). Heart rate was highly heritable both during daytime (57%, P <.001) and night-time (58%, P <.001), but the variability of heart rate, after adjustment, was only significant at night (37%, P <.05). Conclusions: Our data suggest that BPV and HRV are partially under genetic control and that genetic loci of importance for these traits could be mapped by linkage analysis. Am J Hypertens 2005;18:1402-1407 0 2005 American Journal of Hypertension, Ltd. (Less)
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author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
in
American Journal of Hypertension
volume
18
issue
11
pages
1402 - 1407
publisher
Elsevier
conference name
20th Annual Meeting of the American-Society-of-Hypertension
external identifiers
  • wos:000233212600004
  • scopus:27644573129
ISSN
0895-7061
1941-7225
DOI
10.1016/j.amjhyper.2005.05.011
language
English
LU publication?
yes
id
a95311c2-224a-45ca-b4c8-18442aab0fd7 (old id 148011)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16280271&dopt=Abstract
date added to LUP
2007-07-19 10:16:43
date last changed
2017-11-12 03:24:10
@inproceedings{a95311c2-224a-45ca-b4c8-18442aab0fd7,
  abstract     = {Background: Blunted nocturnal blood pressure dipping (NBPD) as well as high variability in blood pressure (BPV) and low variability in heart rate (HRV), are associated with increased cardiovascular morbidity and mortality. The aim of this study was to determine whether these traits are heritable. Methods: We studied 260 healthy siblings without antihypertensive drugs from 118 Swedish families. The BPV and HRV were defined as the standard deviation of BP and heart rate values recorded during 24 h, daytime (6 AM to 10 Pm), and night-time (10 Pm to 6 AM). The NBPD was defined as the ratio between night-time and daytime BP. Heritability was estimated with a maximal likelihood method implemented in the Solar software package with and without adjustment for significant covariates. Results: At night, significant heritability was found for systolic (33%, P &lt;.05), diastolic (36%, P &lt;.05), and mean (42%, P &lt;.01) BPV. After covariate adjustment the corresponding heritability values were 23% (P =.08), 29% (P &lt;.05), and 37% (P &lt;.05). Daytime BPV was not heritable. The heritability of NBPD was 38% (P &lt;.05) for systolic, 9% (P =.29) for diastolic, and 36% (P &lt;.05) for mean BP, but after adjustment only systolic NBPD was significant (29%, P &lt;.05). Heart rate was highly heritable both during daytime (57%, P &lt;.001) and night-time (58%, P &lt;.001), but the variability of heart rate, after adjustment, was only significant at night (37%, P &lt;.05). Conclusions: Our data suggest that BPV and HRV are partially under genetic control and that genetic loci of importance for these traits could be mapped by linkage analysis. Am J Hypertens 2005;18:1402-1407 0 2005 American Journal of Hypertension, Ltd.},
  author       = {Fava, Cristiano and Burri, Philippe and Almgren, Peter and Arcaro, Guido and Groop, Leif and Hulthén, Lennart and Melander, Olle},
  booktitle    = {American Journal of Hypertension},
  issn         = {0895-7061},
  language     = {eng},
  number       = {11},
  pages        = {1402--1407},
  publisher    = {Elsevier},
  title        = {Dipping and variability of blood pressure and heart rate at night are heritable traits.},
  url          = {http://dx.doi.org/10.1016/j.amjhyper.2005.05.011},
  volume       = {18},
  year         = {2005},
}