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Imaging in cell-based therapy for neurodegenerative diseases.

Kirik, Deniz LU ; Breysse, Nathalie LU ; Björklund, Tomas LU ; Besret, Laurent and Hantraye, Philippe (2005) In European Journal of Nuclear Medicine and Molecular Imaging 32(Suppl 2). p.417-434
Abstract
Fetal cell transplantation for the treatment of Parkinsonrsquos and Huntingtonrsquos diseases has been developed over the past two decades and is now in early clinical testing phase. Direct assessment of the graftrsquos survival, integration into the host brain and impact on neuronal functions requires advanced in vivo neuroimaging techniques. Owing to its high sensitivity, positron emission tomography is today the most widely used tool to evaluate the viability and function of the transplanted tissue in the brain. Nuclear magnetic resonance techniques are opening new possibilities for imaging neurochemical events in the brain. The ultimate goal will be to use the combination of multiple imaging modalities for complete functional... (More)
Fetal cell transplantation for the treatment of Parkinsonrsquos and Huntingtonrsquos diseases has been developed over the past two decades and is now in early clinical testing phase. Direct assessment of the graftrsquos survival, integration into the host brain and impact on neuronal functions requires advanced in vivo neuroimaging techniques. Owing to its high sensitivity, positron emission tomography is today the most widely used tool to evaluate the viability and function of the transplanted tissue in the brain. Nuclear magnetic resonance techniques are opening new possibilities for imaging neurochemical events in the brain. The ultimate goal will be to use the combination of multiple imaging modalities for complete functional monitoring of the repair processes in the central nervous system. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Huntingtonrsquos disease, Parkinsonrsquos disease, Cell transplantation, Positron emission tomography, Magnetic resonance imaging
in
European Journal of Nuclear Medicine and Molecular Imaging
volume
32
issue
Suppl 2
pages
417 - 434
publisher
Springer
external identifiers
  • wos:000203011200007
  • scopus:29144503167
ISSN
1619-7070
DOI
10.1007/s00259-005-1909-6
language
English
LU publication?
yes
id
798bfff4-8fd9-4df7-94a0-b34915cfdb12 (old id 148191)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16267643&dopt=Abstract
date added to LUP
2007-07-16 12:48:02
date last changed
2017-01-01 04:56:52
@article{798bfff4-8fd9-4df7-94a0-b34915cfdb12,
  abstract     = {Fetal cell transplantation for the treatment of Parkinsonrsquos and Huntingtonrsquos diseases has been developed over the past two decades and is now in early clinical testing phase. Direct assessment of the graftrsquos survival, integration into the host brain and impact on neuronal functions requires advanced in vivo neuroimaging techniques. Owing to its high sensitivity, positron emission tomography is today the most widely used tool to evaluate the viability and function of the transplanted tissue in the brain. Nuclear magnetic resonance techniques are opening new possibilities for imaging neurochemical events in the brain. The ultimate goal will be to use the combination of multiple imaging modalities for complete functional monitoring of the repair processes in the central nervous system.},
  author       = {Kirik, Deniz and Breysse, Nathalie and Björklund, Tomas and Besret, Laurent and Hantraye, Philippe},
  issn         = {1619-7070},
  keyword      = {Huntingtonrsquos disease,Parkinsonrsquos disease,Cell transplantation,Positron emission tomography,Magnetic resonance imaging},
  language     = {eng},
  number       = {Suppl 2},
  pages        = {417--434},
  publisher    = {Springer},
  series       = {European Journal of Nuclear Medicine and Molecular Imaging},
  title        = {Imaging in cell-based therapy for neurodegenerative diseases.},
  url          = {http://dx.doi.org/10.1007/s00259-005-1909-6},
  volume       = {32},
  year         = {2005},
}