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The Aldose Reductase Inhibitor Fidarestat Suppresses Ischemia-Reperfusion-Induced Inflammatory Response in Rat Retina.

Agardh, Carl-David LU ; Agardh, Elisabet LU ; Obrosova, Irina G and Smith, Maj-Lis LU (2009) In Pharmacology 84(5). p.257-263
Abstract
Recent studies suggest that increased aldose reductase (AR) activity plays an important role in ischemia-reperfusion injury in the retina. The mechanisms are not completely understood, but may be linked to inflammation. In the present study, we investigated whether the AR inhibitor fidarestat suppressed the retinal inflammatory response induced by ischemia-reperfusion in a rat model. The inflammatory response was manifested by increased gene expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 (ICAM-1) as well as elevated protein levels of soluble ICAM-1. This response was partially suppressed by the AR inhibitor fidarestat. The findings may reveal beneficial effects of AR inhibition on retinal inflammation... (More)
Recent studies suggest that increased aldose reductase (AR) activity plays an important role in ischemia-reperfusion injury in the retina. The mechanisms are not completely understood, but may be linked to inflammation. In the present study, we investigated whether the AR inhibitor fidarestat suppressed the retinal inflammatory response induced by ischemia-reperfusion in a rat model. The inflammatory response was manifested by increased gene expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 (ICAM-1) as well as elevated protein levels of soluble ICAM-1. This response was partially suppressed by the AR inhibitor fidarestat. The findings may reveal beneficial effects of AR inhibition on retinal inflammation associated with ischemia-reperfusion and are in agreement with recent developments in pharmacological research suggesting that pathological conditions other than diabetes may benefit from AR inhibitors. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Aldose reductase inhibitor, Fidarestat, Inflammation, Retina, Rat
in
Pharmacology
volume
84
issue
5
pages
257 - 263
publisher
Karger
external identifiers
  • wos:000271024400001
  • pmid:19776662
  • scopus:70349261110
ISSN
1423-0313
DOI
10.1159/000241733
language
English
LU publication?
yes
id
5ad55161-ba04-4abe-bbaa-225d31f22fc7 (old id 1483218)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19776662?dopt=Abstract
date added to LUP
2012-01-19 10:46:38
date last changed
2017-05-21 03:45:04
@article{5ad55161-ba04-4abe-bbaa-225d31f22fc7,
  abstract     = {Recent studies suggest that increased aldose reductase (AR) activity plays an important role in ischemia-reperfusion injury in the retina. The mechanisms are not completely understood, but may be linked to inflammation. In the present study, we investigated whether the AR inhibitor fidarestat suppressed the retinal inflammatory response induced by ischemia-reperfusion in a rat model. The inflammatory response was manifested by increased gene expression of tumor necrosis factor-alpha and intercellular adhesion molecule-1 (ICAM-1) as well as elevated protein levels of soluble ICAM-1. This response was partially suppressed by the AR inhibitor fidarestat. The findings may reveal beneficial effects of AR inhibition on retinal inflammation associated with ischemia-reperfusion and are in agreement with recent developments in pharmacological research suggesting that pathological conditions other than diabetes may benefit from AR inhibitors.},
  author       = {Agardh, Carl-David and Agardh, Elisabet and Obrosova, Irina G and Smith, Maj-Lis},
  issn         = {1423-0313},
  keyword      = {Aldose reductase inhibitor,Fidarestat,Inflammation,Retina,Rat},
  language     = {eng},
  number       = {5},
  pages        = {257--263},
  publisher    = {Karger},
  series       = {Pharmacology},
  title        = {The Aldose Reductase Inhibitor Fidarestat Suppresses Ischemia-Reperfusion-Induced Inflammatory Response in Rat Retina.},
  url          = {http://dx.doi.org/10.1159/000241733},
  volume       = {84},
  year         = {2009},
}