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Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.

Bungum, Mona LU ; Giwercman, Aleksander LU ; Bungum, Leif LU ; Humaidan, Peter; Rastkhani, Hamideh LU and Giwercman, Yvonne LU (2010) In Fertility and Sterility 93(1). p.277-279
Abstract
The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Fertility and Sterility
volume
93
issue
1
pages
277 - 279
publisher
Elsevier
external identifiers
  • wos:000273601200041
  • pmid:19765701
  • scopus:72749110925
ISSN
1556-5653
DOI
10.1016/j.fertnstert.2009.07.984
language
English
LU publication?
yes
id
be7405c5-81c7-4024-9c2e-6a41c0bd06de (old id 1483337)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19765701?dopt=Abstract
date added to LUP
2009-10-07 12:40:16
date last changed
2018-07-08 03:00:31
@article{be7405c5-81c7-4024-9c2e-6a41c0bd06de,
  abstract     = {The aim of this study was to determine whether total fertilization failure in human IVF can be partially explained by alterations in the gene that codes for protein C inhibitor. Forty-six men had IVF total fertilization failure and 51 controls with normal fertilization were screened for mutations in the protein C inhibitor gene by direct sequencing. The main finding was that in men involved in total fertilization failure, a heterozygous adenosine/guanine (A/G) base combination in position 1389 (rs2069990) (exon 6) in the protein C inhibitor gene was significantly more common compared with controls (10.9% vs. 0).},
  author       = {Bungum, Mona and Giwercman, Aleksander and Bungum, Leif and Humaidan, Peter and Rastkhani, Hamideh and Giwercman, Yvonne},
  issn         = {1556-5653},
  language     = {eng},
  number       = {1},
  pages        = {277--279},
  publisher    = {Elsevier},
  series       = {Fertility and Sterility},
  title        = {Polymorphisms in the protein C inhibitor gene in in vitro fertilization failure.},
  url          = {http://dx.doi.org/10.1016/j.fertnstert.2009.07.984},
  volume       = {93},
  year         = {2010},
}