Molds and mycotoxins in indoor environments - a survey in water-damaged buildings.
(2009) In Journal of Occupational and Environmental Hygiene 6(11). p.671-678- Abstract
- Mycotoxins are toxic, secondary metabolites frequently produced by molds in water-damaged indoor environments. We studied the prevalence of selected, potent mycotoxins and levels of fungal biomass in samples collected from water-damaged indoor environments in Sweden during a 1-year period. One hundred samples of building materials, 18 samples of settled dust, and 37 samples of cultured dust were analyzed for: (a) mycoflora by microscopy and culture; (b) fungal chemical marker ergosterol and hydrolysis products of macrocyclic trichothecenes and trichodermin (verrucarol and trichodermol) by gas chromatography-tandem mass spectrometry; and (c) sterigmatocystin, gliotoxin, aflatoxin B(1), and satratoxin G and H by high performance liquid... (More)
- Mycotoxins are toxic, secondary metabolites frequently produced by molds in water-damaged indoor environments. We studied the prevalence of selected, potent mycotoxins and levels of fungal biomass in samples collected from water-damaged indoor environments in Sweden during a 1-year period. One hundred samples of building materials, 18 samples of settled dust, and 37 samples of cultured dust were analyzed for: (a) mycoflora by microscopy and culture; (b) fungal chemical marker ergosterol and hydrolysis products of macrocyclic trichothecenes and trichodermin (verrucarol and trichodermol) by gas chromatography-tandem mass spectrometry; and (c) sterigmatocystin, gliotoxin, aflatoxin B(1), and satratoxin G and H by high performance liquid chromatography-tandem mass spectrometry. Sixty-six percent of the analyzed building materials samples, 11% of the settled dust samples, and 51% of the cultured dust samples were positive for at least one of the studied mycotoxins. In addition, except in the case of gliotoxin, mycotoxin-positive building material samples contained 2-6 times more ergosterol than mycotoxin-negative samples. We show that (a) molds growing on a range of different materials indoors in water-damaged buildings generally produce mycotoxins, and (b) mycotoxin-containing particles in mold-contaminated environments may settle on surfaces above floor level. The mass spectrometry methods used in this study are valuable tools in further research to survey mycotoxin exposure and investigate potential links with health effects. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1483431
- author
- Bloom, Erica LU ; Nyman, Eva ; Must, Aime ; Pehrson, Christina LU and Larsson, Lennart LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Journal of Occupational and Environmental Hygiene
- volume
- 6
- issue
- 11
- pages
- 671 - 678
- publisher
- Taylor & Francis
- external identifiers
-
- wos:000271506200005
- pmid:19757292
- scopus:70349786783
- pmid:19757292
- ISSN
- 1545-9632
- DOI
- 10.1080/15459620903252053
- language
- English
- LU publication?
- yes
- id
- 44ad0cc6-26c7-42c6-a879-a46350f0af1b (old id 1483431)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19757292?dopt=Abstract
- date added to LUP
- 2016-04-04 09:27:10
- date last changed
- 2022-04-23 20:39:50
@article{44ad0cc6-26c7-42c6-a879-a46350f0af1b,
abstract = {{Mycotoxins are toxic, secondary metabolites frequently produced by molds in water-damaged indoor environments. We studied the prevalence of selected, potent mycotoxins and levels of fungal biomass in samples collected from water-damaged indoor environments in Sweden during a 1-year period. One hundred samples of building materials, 18 samples of settled dust, and 37 samples of cultured dust were analyzed for: (a) mycoflora by microscopy and culture; (b) fungal chemical marker ergosterol and hydrolysis products of macrocyclic trichothecenes and trichodermin (verrucarol and trichodermol) by gas chromatography-tandem mass spectrometry; and (c) sterigmatocystin, gliotoxin, aflatoxin B(1), and satratoxin G and H by high performance liquid chromatography-tandem mass spectrometry. Sixty-six percent of the analyzed building materials samples, 11% of the settled dust samples, and 51% of the cultured dust samples were positive for at least one of the studied mycotoxins. In addition, except in the case of gliotoxin, mycotoxin-positive building material samples contained 2-6 times more ergosterol than mycotoxin-negative samples. We show that (a) molds growing on a range of different materials indoors in water-damaged buildings generally produce mycotoxins, and (b) mycotoxin-containing particles in mold-contaminated environments may settle on surfaces above floor level. The mass spectrometry methods used in this study are valuable tools in further research to survey mycotoxin exposure and investigate potential links with health effects.}},
author = {{Bloom, Erica and Nyman, Eva and Must, Aime and Pehrson, Christina and Larsson, Lennart}},
issn = {{1545-9632}},
language = {{eng}},
number = {{11}},
pages = {{671--678}},
publisher = {{Taylor & Francis}},
series = {{Journal of Occupational and Environmental Hygiene}},
title = {{Molds and mycotoxins in indoor environments - a survey in water-damaged buildings.}},
url = {{http://dx.doi.org/10.1080/15459620903252053}},
doi = {{10.1080/15459620903252053}},
volume = {{6}},
year = {{2009}},
}