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GPR30/GPER1: searching for a role in estrogen physiology.

Olde, Björn LU and Leeb-Lundberg, Fredrik LU (2009) In Trends in Endocrinology and Metabolism 20. p.409-416
Abstract
Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular... (More)
Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular and immune systems. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Endocrinology and Metabolism
volume
20
pages
409 - 416
publisher
Elsevier
external identifiers
  • wos:000270764200007
  • pmid:19734054
  • scopus:70349401677
ISSN
1879-3061
DOI
10.1016/j.tem.2009.04.006
language
English
LU publication?
yes
id
e04547c1-f7b0-4b9c-a872-809a40f84985 (old id 1483696)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19734054?dopt=Abstract
date added to LUP
2009-10-07 09:08:50
date last changed
2017-10-22 04:54:58
@article{e04547c1-f7b0-4b9c-a872-809a40f84985,
  abstract     = {Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular and immune systems.},
  author       = {Olde, Björn and Leeb-Lundberg, Fredrik},
  issn         = {1879-3061},
  language     = {eng},
  pages        = {409--416},
  publisher    = {Elsevier},
  series       = {Trends in Endocrinology and Metabolism},
  title        = {GPR30/GPER1: searching for a role in estrogen physiology.},
  url          = {http://dx.doi.org/10.1016/j.tem.2009.04.006},
  volume       = {20},
  year         = {2009},
}