GPR30/GPER1: searching for a role in estrogen physiology.
(2009) In Trends in Endocrinology and Metabolism 20. p.409-416- Abstract
- Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular... (More)
- Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular and immune systems. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1483696
- author
- Olde, Björn LU and Leeb-Lundberg, Fredrik LU
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Trends in Endocrinology and Metabolism
- volume
- 20
- pages
- 409 - 416
- publisher
- Elsevier
- external identifiers
-
- wos:000270764200007
- pmid:19734054
- scopus:70349401677
- ISSN
- 1879-3061
- DOI
- 10.1016/j.tem.2009.04.006
- language
- English
- LU publication?
- yes
- id
- e04547c1-f7b0-4b9c-a872-809a40f84985 (old id 1483696)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19734054?dopt=Abstract
- date added to LUP
- 2016-04-04 08:41:24
- date last changed
- 2025-04-04 14:02:05
@article{e04547c1-f7b0-4b9c-a872-809a40f84985,
abstract = {{Estrogens are sex hormones that are central to health and disease in both genders. These hormones have long been recognized to act in complex ways, both through relatively slow genomic mechanisms and via fast non-genomic mechanisms. Several recent in vitro studies suggest that GPR30, or G protein-coupled estrogen receptor 1 (GPER1), is a functional membrane estrogen receptor involved in non-genomic estrogen signaling. However, this function is not universally accepted. Studies concerning the role of GPER1 in vivo are now beginning to appear but with divergent results. In this review we discuss current knowledge on the physiological role of GPER1 in the nervous system as well as in reproduction, metabolism, bone, and in the cardiovascular and immune systems.}},
author = {{Olde, Björn and Leeb-Lundberg, Fredrik}},
issn = {{1879-3061}},
language = {{eng}},
pages = {{409--416}},
publisher = {{Elsevier}},
series = {{Trends in Endocrinology and Metabolism}},
title = {{GPR30/GPER1: searching for a role in estrogen physiology.}},
url = {{http://dx.doi.org/10.1016/j.tem.2009.04.006}},
doi = {{10.1016/j.tem.2009.04.006}},
volume = {{20}},
year = {{2009}},
}