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Cytogenetic abnormalities in 106 oral squamous cell carcinomas

Jin, Charlotte LU ; Jin, Yuesheng LU ; Wennerberg, Johan LU orcid ; Annertz, Karin LU ; Enoksson, Jens LU and Mertens, Fredrik LU (2006) In Cancer Genetics and Cytogenetics 164(1). p.44-53
Abstract

We report karyotypic features of 106 short-term cultured oral squamous cell carcinomas (SCC), 51 new and 55 previously reported cases, with clonal chromosome aberrations. The major cytogenetic findings were as follows: simple karyotypic changes were present in 38 cases (36%) and 68 tumors (64%) displayed complex karyotypes. The most common numerical changes were +7, +8, +9, +16, +18, +20, and -4, -10, -13, -14, -18, -19, -21, -22, and -Y. Structural rearrangements frequently (43% of the breaks) affected the centromeric regions, resulting in the formation of isochromosomes and whole-arm translocations. Among the recurrent structural aberrations identified, the most common were i(1q), i(3q), i(5p), i(8q), del(16)(q22), and hsr. With the... (More)

We report karyotypic features of 106 short-term cultured oral squamous cell carcinomas (SCC), 51 new and 55 previously reported cases, with clonal chromosome aberrations. The major cytogenetic findings were as follows: simple karyotypic changes were present in 38 cases (36%) and 68 tumors (64%) displayed complex karyotypes. The most common numerical changes were +7, +8, +9, +16, +18, +20, and -4, -10, -13, -14, -18, -19, -21, -22, and -Y. Structural rearrangements frequently (43% of the breaks) affected the centromeric regions, resulting in the formation of isochromosomes and whole-arm translocations. Among the recurrent structural aberrations identified, the most common were i(1q), i(3q), i(5p), i(8q), del(16)(q22), and hsr. With the exception of chromosomal band 11q13, which was involved in 25 tumors, only centromeric or near-centromeric bands were commonly involved: 3p11 approximately q11 (59 cases), 8p11 approximately q11 (57), 1p11 approximately q11 (48), 13p11 approximately q11 (46), 5p11 approximately q11 (41), 14p11 approximately q11 (41), and 15p11 approximately q11 (37). Losses of genetic material dominated over gains. The most frequent imbalances included loss of 2q33 approximately qter, 3p, 4p, 6q, 8p, 10p, 11q, 13p, 14p, and 15p, and chromosomes 18, 21, 22, and Y, and gain of chromosomes 7 and 20, 8q, and 11q13. No major karyotypic differences could be discerned between the present series of oral SCC and a previously reported series of laryngeal SCC, indicating that common genetic pathways are involved in the initiation and progression of SCC irrespective of site of origin.

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keywords
Adult, Aged, Aged, 80 and over, Carcinoma, Squamous Cell, Chromosome Aberrations, Female, Humans, Male, Middle Aged, Mouth Neoplasms, Smoking, Journal Article, Research Support, Non-U.S. Gov't
in
Cancer Genetics and Cytogenetics
volume
164
issue
1
pages
10 pages
publisher
Elsevier
external identifiers
  • pmid:16364762
  • wos:000234675000007
  • scopus:29244434129
  • pmid:16364762
ISSN
0165-4608
DOI
10.1016/j.cancergencyto.2005.06.008
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Clinical Genetics (013022003), Pathology, (Lund) (013030000), Otorhinolaryngology (Lund) (013044000)
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d1a6bc3c-fd99-4b82-964e-7a819d6f097b (old id 148577)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16364762&dopt=Abstract
date added to LUP
2016-04-01 17:02:30
date last changed
2021-08-04 03:02:04
@article{d1a6bc3c-fd99-4b82-964e-7a819d6f097b,
  abstract     = {<p>We report karyotypic features of 106 short-term cultured oral squamous cell carcinomas (SCC), 51 new and 55 previously reported cases, with clonal chromosome aberrations. The major cytogenetic findings were as follows: simple karyotypic changes were present in 38 cases (36%) and 68 tumors (64%) displayed complex karyotypes. The most common numerical changes were +7, +8, +9, +16, +18, +20, and -4, -10, -13, -14, -18, -19, -21, -22, and -Y. Structural rearrangements frequently (43% of the breaks) affected the centromeric regions, resulting in the formation of isochromosomes and whole-arm translocations. Among the recurrent structural aberrations identified, the most common were i(1q), i(3q), i(5p), i(8q), del(16)(q22), and hsr. With the exception of chromosomal band 11q13, which was involved in 25 tumors, only centromeric or near-centromeric bands were commonly involved: 3p11 approximately q11 (59 cases), 8p11 approximately q11 (57), 1p11 approximately q11 (48), 13p11 approximately q11 (46), 5p11 approximately q11 (41), 14p11 approximately q11 (41), and 15p11 approximately q11 (37). Losses of genetic material dominated over gains. The most frequent imbalances included loss of 2q33 approximately qter, 3p, 4p, 6q, 8p, 10p, 11q, 13p, 14p, and 15p, and chromosomes 18, 21, 22, and Y, and gain of chromosomes 7 and 20, 8q, and 11q13. No major karyotypic differences could be discerned between the present series of oral SCC and a previously reported series of laryngeal SCC, indicating that common genetic pathways are involved in the initiation and progression of SCC irrespective of site of origin.</p>},
  author       = {Jin, Charlotte and Jin, Yuesheng and Wennerberg, Johan and Annertz, Karin and Enoksson, Jens and Mertens, Fredrik},
  issn         = {0165-4608},
  language     = {eng},
  month        = {01},
  number       = {1},
  pages        = {44--53},
  publisher    = {Elsevier},
  series       = {Cancer Genetics and Cytogenetics},
  title        = {Cytogenetic abnormalities in 106 oral squamous cell carcinomas},
  url          = {http://dx.doi.org/10.1016/j.cancergencyto.2005.06.008},
  doi          = {10.1016/j.cancergencyto.2005.06.008},
  volume       = {164},
  year         = {2006},
}