Advanced

Functional magnetic resonance imaging at 3T as a clinical tool in patients with intracranial tumors.

van Westen, Danielle LU ; Skagerberg, Gunnar LU ; Olsrud, Johan LU ; Fransson, P and Larsson, Elna-Marie LU (2005) In Acta Radiologica 46(6). p.599-609
Abstract
Purpose: To investigate the potential of functional magnetic resonance imaging (fMRI) at 3T as a clinical tool in the preoperative evaluation of patients with intracranial tumors. High magnetic field strength such as 3T is of benefit for fMRI because signal-to-noise ratio and sensitivity to susceptibility changes are field-strength-dependent.



Material and Methods: Twenty patients with tumors close to eloquent sensorimotor or language areas were studied. Motor, sensory, and two language paradigms (word generation, rhyming) were used; their effectiveness was determined as the percentage of patients in whom the functional area of interest was activated. Activation maps were calculated and their quality rated as high,... (More)
Purpose: To investigate the potential of functional magnetic resonance imaging (fMRI) at 3T as a clinical tool in the preoperative evaluation of patients with intracranial tumors. High magnetic field strength such as 3T is of benefit for fMRI because signal-to-noise ratio and sensitivity to susceptibility changes are field-strength-dependent.



Material and Methods: Twenty patients with tumors close to eloquent sensorimotor or language areas were studied. Motor, sensory, and two language paradigms (word generation, rhyming) were used; their effectiveness was determined as the percentage of patients in whom the functional area of interest was activated. Activation maps were calculated and their quality rated as high, adequate, or insufficient. The influence of fMRI on the neurosurgical decision regarding operability, surgical approach, and extent of the resection, was assessed.



Results: Paradigm effectiveness was 90% for motor and 95% for sensory stimulation, and varied from 79% to 95% for word generation and rhyming in combination. Ninety percent of the activation maps held high or adequate quality. fMRI proved useful: in the decision to operate (9 patients), in the surgical approach (13 patients), and in extent of the resection (12 patients).



Conclusion: fMRI at 3T is a clinically applicable tool in the work-up of patients with intracranial tumors. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Functional magnetic resonance imaging, intracranial tumors
in
Acta Radiologica
volume
46
issue
6
pages
599 - 609
publisher
John Wiley & Sons
external identifiers
  • pmid:16334841
  • wos:000232782700009
  • scopus:33644701402
ISSN
1600-0455
DOI
10.1080/02841850510021652
language
English
LU publication?
yes
id
b110f8fd-407a-4663-97e8-29ca9833d44f (old id 148822)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16334841&dopt=Abstract
date added to LUP
2007-07-17 11:25:15
date last changed
2017-01-01 07:04:23
@article{b110f8fd-407a-4663-97e8-29ca9833d44f,
  abstract     = {Purpose: To investigate the potential of functional magnetic resonance imaging (fMRI) at 3T as a clinical tool in the preoperative evaluation of patients with intracranial tumors. High magnetic field strength such as 3T is of benefit for fMRI because signal-to-noise ratio and sensitivity to susceptibility changes are field-strength-dependent.<br/><br>
<br/><br>
Material and Methods: Twenty patients with tumors close to eloquent sensorimotor or language areas were studied. Motor, sensory, and two language paradigms (word generation, rhyming) were used; their effectiveness was determined as the percentage of patients in whom the functional area of interest was activated. Activation maps were calculated and their quality rated as high, adequate, or insufficient. The influence of fMRI on the neurosurgical decision regarding operability, surgical approach, and extent of the resection, was assessed.<br/><br>
<br/><br>
Results: Paradigm effectiveness was 90% for motor and 95% for sensory stimulation, and varied from 79% to 95% for word generation and rhyming in combination. Ninety percent of the activation maps held high or adequate quality. fMRI proved useful: in the decision to operate (9 patients), in the surgical approach (13 patients), and in extent of the resection (12 patients).<br/><br>
<br/><br>
Conclusion: fMRI at 3T is a clinically applicable tool in the work-up of patients with intracranial tumors.},
  author       = {van Westen, Danielle and Skagerberg, Gunnar and Olsrud, Johan and Fransson, P and Larsson, Elna-Marie},
  issn         = {1600-0455},
  keyword      = {Functional magnetic resonance imaging,intracranial tumors},
  language     = {eng},
  number       = {6},
  pages        = {599--609},
  publisher    = {John Wiley & Sons},
  series       = {Acta Radiologica},
  title        = {Functional magnetic resonance imaging at 3T as a clinical tool in patients with intracranial tumors.},
  url          = {http://dx.doi.org/10.1080/02841850510021652},
  volume       = {46},
  year         = {2005},
}