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Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm

Wolfstetter, Georg; Shirinian, Margret; Stute, Christiana; Grabbe, Caroline; Hummel, Thomas; Baumgartner, Stefan LU ; Palmer, Ruth H. and Holz, Anne (2009) In Mechanisms of Development 126(8-9). p.721-736
Abstract
In this study we describe the morphological and genetic analysis of the Drosophila mutant gurtelchen (gurt). gurt was identified by screening an EMS collection for novel mutations affecting visceral mesoderm development and was named after the distinct belt shaped visceral phenotype. Interestingly, determination of visceral cell identities and subsequent visceral myoblast fusion is not affected in mutant embryos indicating a later defect in visceral development. gurt is in fact a new huckebein (hkb) allele and as such exhibits nearly complete loss of endodermal derived structures. Targeted ablation of the endodermal primordia produces a phenotype that resembles the visceral defects observed in huckebein(gurtelchen) (hkb(gurt)) mutant... (More)
In this study we describe the morphological and genetic analysis of the Drosophila mutant gurtelchen (gurt). gurt was identified by screening an EMS collection for novel mutations affecting visceral mesoderm development and was named after the distinct belt shaped visceral phenotype. Interestingly, determination of visceral cell identities and subsequent visceral myoblast fusion is not affected in mutant embryos indicating a later defect in visceral development. gurt is in fact a new huckebein (hkb) allele and as such exhibits nearly complete loss of endodermal derived structures. Targeted ablation of the endodermal primordia produces a phenotype that resembles the visceral defects observed in huckebein(gurtelchen) (hkb(gurt)) mutant embryos. It was shown previously that visceral mesoderm development requires complex interactions between visceral myoblasts and adjacent tissues. Signals from the neighbouring somatic myoblasts; play an important role in cell type determination and are a prerequisite for visceral muscle fusion. Furthermore, the visceral mesoderm is known to influence endodermal migration and midgut epithelium formation. our analyses of the visceral phenotype of hkb(gurt) mutant embryos reveal that the adjacent endoderm plays a critical role in the later stages of visceral muscle development, and is required for visceral muscle elongation and outgrowth after proper myoblast fusion. (C) 2009 Elsevier Ireland Ltd. All rights reserved (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
gurtelchen, FCMs, FCs, Myoblast, Myogenesis, Visceral mesoderm, gurt, huckebein, hkb
in
Mechanisms of Development
volume
126
issue
8-9
pages
721 - 736
publisher
Elsevier
external identifiers
  • wos:000270214200011
  • scopus:68449093091
ISSN
0925-4773
DOI
10.1016/j.mod.2009.05.001
language
English
LU publication?
yes
id
250de401-5abf-4743-adb2-9c44a6b3ce8c (old id 1489973)
date added to LUP
2009-10-21 10:14:32
date last changed
2017-11-05 03:29:11
@article{250de401-5abf-4743-adb2-9c44a6b3ce8c,
  abstract     = {In this study we describe the morphological and genetic analysis of the Drosophila mutant gurtelchen (gurt). gurt was identified by screening an EMS collection for novel mutations affecting visceral mesoderm development and was named after the distinct belt shaped visceral phenotype. Interestingly, determination of visceral cell identities and subsequent visceral myoblast fusion is not affected in mutant embryos indicating a later defect in visceral development. gurt is in fact a new huckebein (hkb) allele and as such exhibits nearly complete loss of endodermal derived structures. Targeted ablation of the endodermal primordia produces a phenotype that resembles the visceral defects observed in huckebein(gurtelchen) (hkb(gurt)) mutant embryos. It was shown previously that visceral mesoderm development requires complex interactions between visceral myoblasts and adjacent tissues. Signals from the neighbouring somatic myoblasts; play an important role in cell type determination and are a prerequisite for visceral muscle fusion. Furthermore, the visceral mesoderm is known to influence endodermal migration and midgut epithelium formation. our analyses of the visceral phenotype of hkb(gurt) mutant embryos reveal that the adjacent endoderm plays a critical role in the later stages of visceral muscle development, and is required for visceral muscle elongation and outgrowth after proper myoblast fusion. (C) 2009 Elsevier Ireland Ltd. All rights reserved},
  author       = {Wolfstetter, Georg and Shirinian, Margret and Stute, Christiana and Grabbe, Caroline and Hummel, Thomas and Baumgartner, Stefan and Palmer, Ruth H. and Holz, Anne},
  issn         = {0925-4773},
  keyword      = {gurtelchen,FCMs,FCs,Myoblast,Myogenesis,Visceral mesoderm,gurt,huckebein,hkb},
  language     = {eng},
  number       = {8-9},
  pages        = {721--736},
  publisher    = {Elsevier},
  series       = {Mechanisms of Development},
  title        = {Fusion of circular and longitudinal muscles in Drosophila is independent of the endoderm but further visceral muscle differentiation requires a close contact between mesoderm and endoderm},
  url          = {http://dx.doi.org/10.1016/j.mod.2009.05.001},
  volume       = {126},
  year         = {2009},
}