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Modeling the increase of nodularin content in Baltic Sea Nodularia spumigena during stationary phase in phosphorus-limited batch cultures

Stolte, W; Karlsson, C; Carlsson, Per LU and Graneli, Edna LU (2002) In FEMS Microbiology Ecology 41(3). p.211-220
Abstract
Nodularin (Nod), produced by the brackish/marine cyanobacterium Nodularia spumigena, is a potent hepatotoxin, tumor promoter and is possibly carcinogenic to mammals. It is structurally and toxicologically related to the microcystins, produced by Microcystis aeruginosa in fresh water. A better understanding of the kinetics of Nod production might provide an insight into the physiological and ecological function of cyanobacterial hepatotoxins. The present study presents a simple model simulating the concentration of Nod in N. spumigena KAC66 during phosphorus-limited growth. The main assumption of the model is that the Nod production rate is proportional to the chlorophyll-a (Chla) concentration. The model was tuned to data from... (More)
Nodularin (Nod), produced by the brackish/marine cyanobacterium Nodularia spumigena, is a potent hepatotoxin, tumor promoter and is possibly carcinogenic to mammals. It is structurally and toxicologically related to the microcystins, produced by Microcystis aeruginosa in fresh water. A better understanding of the kinetics of Nod production might provide an insight into the physiological and ecological function of cyanobacterial hepatotoxins. The present study presents a simple model simulating the concentration of Nod in N. spumigena KAC66 during phosphorus-limited growth. The main assumption of the model is that the Nod production rate is proportional to the chlorophyll-a (Chla) concentration. The model was tuned to data from phosphorus-limited batch cultures of N. spumigena KAC66 at saturating light and was able to predict 96% or more of the variation in both Chla and Nod concentration. No significant effect of available nitrogen source was found on the Chla-specific Nod production rate although specific growth rates were higher in ammonium and nitrate grown cultures compared to cultures grown with N2 as the sole nitrogen source. Literature data on microcystin production by M. aeruginosa in phosphorus-limited chemostats fitted the model predictions well, except at very low dilution rates (0.1 day−1). The good fit with the proposed model to our own and literature data suggests that the production of hepatotoxic cyanotoxins is not regulated upon growth reduction due to phosphate limitation. (Less)
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author
publishing date
type
Contribution to journal
publication status
published
subject
in
FEMS Microbiology Ecology
volume
41
issue
3
pages
211 - 220
publisher
Elsevier
external identifiers
  • scopus:0036051324
ISSN
1574-6941
DOI
10.1016/S0168-6496(02)00295-7
language
English
LU publication?
no
id
9801f494-88ff-4eac-8223-39a964a53d3f (old id 149913)
date added to LUP
2007-06-29 07:58:09
date last changed
2017-07-30 04:28:16
@article{9801f494-88ff-4eac-8223-39a964a53d3f,
  abstract     = {Nodularin (Nod), produced by the brackish/marine cyanobacterium Nodularia spumigena, is a potent hepatotoxin, tumor promoter and is possibly carcinogenic to mammals. It is structurally and toxicologically related to the microcystins, produced by Microcystis aeruginosa in fresh water. A better understanding of the kinetics of Nod production might provide an insight into the physiological and ecological function of cyanobacterial hepatotoxins. The present study presents a simple model simulating the concentration of Nod in N. spumigena KAC66 during phosphorus-limited growth. The main assumption of the model is that the Nod production rate is proportional to the chlorophyll-a (Chla) concentration. The model was tuned to data from phosphorus-limited batch cultures of N. spumigena KAC66 at saturating light and was able to predict 96% or more of the variation in both Chla and Nod concentration. No significant effect of available nitrogen source was found on the Chla-specific Nod production rate although specific growth rates were higher in ammonium and nitrate grown cultures compared to cultures grown with N2 as the sole nitrogen source. Literature data on microcystin production by M. aeruginosa in phosphorus-limited chemostats fitted the model predictions well, except at very low dilution rates (0.1 day−1). The good fit with the proposed model to our own and literature data suggests that the production of hepatotoxic cyanotoxins is not regulated upon growth reduction due to phosphate limitation.},
  author       = {Stolte, W and Karlsson, C and Carlsson, Per and Graneli, Edna},
  issn         = {1574-6941},
  language     = {eng},
  number       = {3},
  pages        = {211--220},
  publisher    = {Elsevier},
  series       = {FEMS Microbiology Ecology},
  title        = {Modeling the increase of nodularin content in Baltic Sea Nodularia spumigena during stationary phase in phosphorus-limited batch cultures},
  url          = {http://dx.doi.org/10.1016/S0168-6496(02)00295-7},
  volume       = {41},
  year         = {2002},
}