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Loss of inhibition in ipsilateral somatosensory areas following altered afferent nerve signaling from the hand

Björkman, Anders LU and Weibull, Andreas LU (2017) In Neuroscience Research
Abstract

Cutaneous stimulation of the hand results in increased neural activity in the contralateral primary somatosensory cortex (S1) in humans, whereas an inhibition of neurons is seen in the ipsilateral S1.The aim of this study was to assess changes in neural activity in the S1 bilaterally, with a focus on the ipsilateral hemisphere, following altered afferent nerve signaling from the hand. Three cohorts, all with altered afferent nerve signaling from the hand, participated in the study. There were: 18 patients with traumatic median nerve injury, 10 patients with vibration induced neuropathy and 11 healthy subjects who had their dominant hand and wrist immobilized for 72 h. In addition, 36 healthy subjects were included as controls. Each... (More)

Cutaneous stimulation of the hand results in increased neural activity in the contralateral primary somatosensory cortex (S1) in humans, whereas an inhibition of neurons is seen in the ipsilateral S1.The aim of this study was to assess changes in neural activity in the S1 bilaterally, with a focus on the ipsilateral hemisphere, following altered afferent nerve signaling from the hand. Three cohorts, all with altered afferent nerve signaling from the hand, participated in the study. There were: 18 patients with traumatic median nerve injury, 10 patients with vibration induced neuropathy and 11 healthy subjects who had their dominant hand and wrist immobilized for 72 h. In addition, 36 healthy subjects were included as controls. Each subject was examined using functional magnetic resonance imaging at 3 T. All three study cohorts showed enlarged activation in the contralateral S1 during tactile stimulation compared to healthy controls. Moreover, inhibition of the ipsilateral S1 was significantly decreased or completely lost. Thus, somatosensory areas of both hemispheres respond to changed afferent nerve signaling from the hand. The loss of inhibition of neurons in the ipsilateral S1 suggests an important role of the ipsilateral hemisphere in the cerebral adaptation following a change in afferent nerve signaling.

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author
organization
publishing date
type
Contribution to journal
publication status
epub
subject
keywords
FMRI, Neuropathy, Peripheral nerve injury, Plasticity, Reorganization
in
Neuroscience Research
publisher
Elsevier
external identifiers
  • scopus:85039559791
ISSN
0168-0102
DOI
10.1016/j.neures.2017.12.004
language
English
LU publication?
yes
id
149b3157-804e-45ee-9192-bf6b21f320e7
date added to LUP
2018-01-10 08:08:19
date last changed
2018-01-11 03:00:07
@article{149b3157-804e-45ee-9192-bf6b21f320e7,
  abstract     = {<p>Cutaneous stimulation of the hand results in increased neural activity in the contralateral primary somatosensory cortex (S1) in humans, whereas an inhibition of neurons is seen in the ipsilateral S1.The aim of this study was to assess changes in neural activity in the S1 bilaterally, with a focus on the ipsilateral hemisphere, following altered afferent nerve signaling from the hand. Three cohorts, all with altered afferent nerve signaling from the hand, participated in the study. There were: 18 patients with traumatic median nerve injury, 10 patients with vibration induced neuropathy and 11 healthy subjects who had their dominant hand and wrist immobilized for 72 h. In addition, 36 healthy subjects were included as controls. Each subject was examined using functional magnetic resonance imaging at 3 T. All three study cohorts showed enlarged activation in the contralateral S1 during tactile stimulation compared to healthy controls. Moreover, inhibition of the ipsilateral S1 was significantly decreased or completely lost. Thus, somatosensory areas of both hemispheres respond to changed afferent nerve signaling from the hand. The loss of inhibition of neurons in the ipsilateral S1 suggests an important role of the ipsilateral hemisphere in the cerebral adaptation following a change in afferent nerve signaling.</p>},
  author       = {Björkman, Anders and Weibull, Andreas},
  issn         = {0168-0102},
  keyword      = {FMRI,Neuropathy,Peripheral nerve injury,Plasticity,Reorganization},
  language     = {eng},
  month        = {12},
  publisher    = {Elsevier},
  series       = {Neuroscience Research},
  title        = {Loss of inhibition in ipsilateral somatosensory areas following altered afferent nerve signaling from the hand},
  url          = {http://dx.doi.org/10.1016/j.neures.2017.12.004},
  year         = {2017},
}