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Stabilins are expressed in bone marrow sinusoidal endothelial cells and mediate scavenging and cell adhesive functions.

Qian, Hong LU ; Johansson, Sophie; McCourt, Peter; Smedsrød, Bård; Ekblom, Marja LU and Johansson, Staffan LU (2009) In Biochemical and Biophysical Research Communications 390. p.883-886
Abstract
Bone marrow sinusoidal endothelial cells have a specific function as a site of transmigration of hematopoietic stem and progenitor cells and mature blood cells between bone marrow and blood stream. However, the specific characteristics of bone marrow sinusoidal endothelial cells are still largely unclear. We here report that these cells express stabilin-1 and stabilin-2, which in liver sinusoidal endothelial cells have been identified as endocytic scavenger receptors for several ligands, including SPARC and hyaluronan. We show here that intravenously injected formaldehyde-treated serum albumin, advanced glycation end-products, and collagen I alpha-chains were taken up by bone marrow sinusoidal endothelial cells, showing that these cells... (More)
Bone marrow sinusoidal endothelial cells have a specific function as a site of transmigration of hematopoietic stem and progenitor cells and mature blood cells between bone marrow and blood stream. However, the specific characteristics of bone marrow sinusoidal endothelial cells are still largely unclear. We here report that these cells express stabilin-1 and stabilin-2, which in liver sinusoidal endothelial cells have been identified as endocytic scavenger receptors for several ligands, including SPARC and hyaluronan. We show here that intravenously injected formaldehyde-treated serum albumin, advanced glycation end-products, and collagen I alpha-chains were taken up by bone marrow sinusoidal endothelial cells, showing that these cells have a scavenging function and thereby may modulate bone marrow vascular stem cell niches. Importantly, we show hyaluronan mediated adhesion of hematopoietic stem and progenitor cells to stabilin-2-transfected cells, suggesting that stabilin-2 contributes to adhesion and homing of circulating stem and progenitor cells to bone marrow. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical and Biophysical Research Communications
volume
390
pages
883 - 886
publisher
Elsevier
external identifiers
  • wos:000272516700097
  • pmid:19850011
  • scopus:70449710747
ISSN
1090-2104
DOI
10.1016/j.bbrc.2009.10.068
language
English
LU publication?
yes
id
20096da1-54c6-45ba-9924-e6141489f271 (old id 1500078)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19850011?dopt=Abstract
date added to LUP
2009-11-03 13:12:27
date last changed
2017-05-28 04:38:37
@article{20096da1-54c6-45ba-9924-e6141489f271,
  abstract     = {Bone marrow sinusoidal endothelial cells have a specific function as a site of transmigration of hematopoietic stem and progenitor cells and mature blood cells between bone marrow and blood stream. However, the specific characteristics of bone marrow sinusoidal endothelial cells are still largely unclear. We here report that these cells express stabilin-1 and stabilin-2, which in liver sinusoidal endothelial cells have been identified as endocytic scavenger receptors for several ligands, including SPARC and hyaluronan. We show here that intravenously injected formaldehyde-treated serum albumin, advanced glycation end-products, and collagen I alpha-chains were taken up by bone marrow sinusoidal endothelial cells, showing that these cells have a scavenging function and thereby may modulate bone marrow vascular stem cell niches. Importantly, we show hyaluronan mediated adhesion of hematopoietic stem and progenitor cells to stabilin-2-transfected cells, suggesting that stabilin-2 contributes to adhesion and homing of circulating stem and progenitor cells to bone marrow.},
  author       = {Qian, Hong and Johansson, Sophie and McCourt, Peter and Smedsrød, Bård and Ekblom, Marja and Johansson, Staffan},
  issn         = {1090-2104},
  language     = {eng},
  pages        = {883--886},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Stabilins are expressed in bone marrow sinusoidal endothelial cells and mediate scavenging and cell adhesive functions.},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2009.10.068},
  volume       = {390},
  year         = {2009},
}