Leukocyte count is associated with incidence of coronary events, but not with stroke: A prospective cohort study.
(2010) In Atherosclerosis 209. p.545-550- Abstract
- OBJECTIVE: Elevated leukocyte count is a classic marker of systemic inflammation. This study examined whether the leukocyte count is associated with incidence of coronary events (CE) and stroke during a long follow-up period. METHODS: A total of 17,131 men and 2932 women, aged 27-61 years, without history of cardiovascular disease (CVD), were enrolled. Incidence of CE and stroke was studied in relation to leukocyte concentrations over a mean follow-up of 24 years. RESULTS: During the follow-up period, 2600 CE and 1333 stroke events occurred. After risk factor adjustments, leukocyte concentrations in the highest quartile (vs. lowest, >7.0 vs. <4.7x10(9)cells/L) were associated with CE in men (HR: 1.31, 95%CI: 1.16-1.48, trend... (More)
- OBJECTIVE: Elevated leukocyte count is a classic marker of systemic inflammation. This study examined whether the leukocyte count is associated with incidence of coronary events (CE) and stroke during a long follow-up period. METHODS: A total of 17,131 men and 2932 women, aged 27-61 years, without history of cardiovascular disease (CVD), were enrolled. Incidence of CE and stroke was studied in relation to leukocyte concentrations over a mean follow-up of 24 years. RESULTS: During the follow-up period, 2600 CE and 1333 stroke events occurred. After risk factor adjustments, leukocyte concentrations in the highest quartile (vs. lowest, >7.0 vs. <4.7x10(9)cells/L) were associated with CE in men (HR: 1.31, 95%CI: 1.16-1.48, trend p<0.001), but not significantly in women (HR: 1.46, CI: 0.87-2.46, trend p=0.13). The increased incidence remained significant after adjustments for plasma fibrinogen in a sub-group of 6018 men (HR: 1.31, CI: 1.08-1.60). The association between leukocytes and CE was most pronounced in younger men (aged 27-46) and men without hypertension. In younger men, high leukocytes were associated with early CE (within 10 years of follow-up) and late CE (>10 years of follow-up). In older men (46-61 years), leukocytes were not associated with CE after more than 10 years of follow-up. The leukocyte count was not associated with incidence of stroke. CONCLUSION: Elevated leukocyte count in men is associated with increased incidence of CE, but not with stroke. The increased risk persisted after more than 10 years of follow-up in younger, but not in older men. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1500306
- author
- Li, Cairu LU ; Engström, Gunnar LU and Hedblad, Bo LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Atherosclerosis
- volume
- 209
- pages
- 545 - 550
- publisher
- Elsevier
- external identifiers
-
- wos:000276158000038
- pmid:19833340
- scopus:77950021916
- pmid:19833340
- ISSN
- 1879-1484
- DOI
- 10.1016/j.atherosclerosis.2009.09.029
- language
- English
- LU publication?
- yes
- id
- fabfbd1a-fc6f-458b-a922-0dd0a98dd8a1 (old id 1500306)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19833340?dopt=Abstract
- date added to LUP
- 2016-04-04 08:48:32
- date last changed
- 2022-01-29 03:59:10
@article{fabfbd1a-fc6f-458b-a922-0dd0a98dd8a1, abstract = {{OBJECTIVE: Elevated leukocyte count is a classic marker of systemic inflammation. This study examined whether the leukocyte count is associated with incidence of coronary events (CE) and stroke during a long follow-up period. METHODS: A total of 17,131 men and 2932 women, aged 27-61 years, without history of cardiovascular disease (CVD), were enrolled. Incidence of CE and stroke was studied in relation to leukocyte concentrations over a mean follow-up of 24 years. RESULTS: During the follow-up period, 2600 CE and 1333 stroke events occurred. After risk factor adjustments, leukocyte concentrations in the highest quartile (vs. lowest, >7.0 vs. <4.7x10(9)cells/L) were associated with CE in men (HR: 1.31, 95%CI: 1.16-1.48, trend p<0.001), but not significantly in women (HR: 1.46, CI: 0.87-2.46, trend p=0.13). The increased incidence remained significant after adjustments for plasma fibrinogen in a sub-group of 6018 men (HR: 1.31, CI: 1.08-1.60). The association between leukocytes and CE was most pronounced in younger men (aged 27-46) and men without hypertension. In younger men, high leukocytes were associated with early CE (within 10 years of follow-up) and late CE (>10 years of follow-up). In older men (46-61 years), leukocytes were not associated with CE after more than 10 years of follow-up. The leukocyte count was not associated with incidence of stroke. CONCLUSION: Elevated leukocyte count in men is associated with increased incidence of CE, but not with stroke. The increased risk persisted after more than 10 years of follow-up in younger, but not in older men.}}, author = {{Li, Cairu and Engström, Gunnar and Hedblad, Bo}}, issn = {{1879-1484}}, language = {{eng}}, pages = {{545--550}}, publisher = {{Elsevier}}, series = {{Atherosclerosis}}, title = {{Leukocyte count is associated with incidence of coronary events, but not with stroke: A prospective cohort study.}}, url = {{https://lup.lub.lu.se/search/files/5197613/1508356.pdf}}, doi = {{10.1016/j.atherosclerosis.2009.09.029}}, volume = {{209}}, year = {{2010}}, }