Advanced

Single semen analysis as a predictor of semen quality: clinical and epidemiological implications.

Rylander, Lars LU ; Wetterstrand, Boel; Haugen, Trine B; Malm, Gunilla LU ; Malm, Johan LU ; Bjørsvik, Cathrine; Henrichsen, Trine; Sæther, Thomas and Giwercman, Aleksander LU (2009) In Asian Journal of Andrology 11. p.723-730
Abstract
It is generally thought that a single ejaculate is a bad predictor of semen quality of a subject, because of significant intra-individual variation. Therefore, we investigated the degree to which the results of a first semen analysis differ from that of a second analysis among men from a general population in Norway. In addition, we analysed how the two different semen results mirrored the overall semen quality assessment. A total of 199 volunteers participated in the study and delivered two semen samples with an interval of 6 months. The semen parameters were determined according to the World Health Organization (WHO) 1999 guidelines, which were also used to determine whether semen quality was normal or abnormal. In addition, the DNA... (More)
It is generally thought that a single ejaculate is a bad predictor of semen quality of a subject, because of significant intra-individual variation. Therefore, we investigated the degree to which the results of a first semen analysis differ from that of a second analysis among men from a general population in Norway. In addition, we analysed how the two different semen results mirrored the overall semen quality assessment. A total of 199 volunteers participated in the study and delivered two semen samples with an interval of 6 months. The semen parameters were determined according to the World Health Organization (WHO) 1999 guidelines, which were also used to determine whether semen quality was normal or abnormal. In addition, the DNA fragmentation index (DFI) was determined using the Sperm Chromatin Structure Assay. The two samples from each individual were very similar with regard to standard semen parameters and DFI (r(s:) 0.67-0.72), and there were no significant systematic differences between the two samples. The result of the first sample (normal/abnormal) was highly predictive of the overall conclusion based on the two samples (sperm concentration: in 93% of the cases (95% confidence interval [CI]: 89%-96%); sperm motility: in 85% of the cases (95% CI: 79%-89%); overall semen quality: in 85% of the cases (95% CI: 80%-90%). In epidemiological studies, one ejaculate is a sufficient indicator of semen quality in a group of subjects. In a clinical situation, when the question is whether the semen quality is normal or not, the first ejaculate will, in at least 85% of cases, give a correct overall conclusion. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Asian Journal of Andrology
volume
11
pages
723 - 730
publisher
Nature Publishing Group
external identifiers
  • wos:000271429400011
  • pmid:19823177
  • scopus:71049153243
ISSN
1008-682X
DOI
10.1038/aja.2009.64
language
English
LU publication?
yes
id
c7c13d11-c6fc-4122-b627-6099ce197fb6 (old id 1500399)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19823177?dopt=Abstract
date added to LUP
2009-11-03 14:55:42
date last changed
2017-12-10 04:42:08
@article{c7c13d11-c6fc-4122-b627-6099ce197fb6,
  abstract     = {It is generally thought that a single ejaculate is a bad predictor of semen quality of a subject, because of significant intra-individual variation. Therefore, we investigated the degree to which the results of a first semen analysis differ from that of a second analysis among men from a general population in Norway. In addition, we analysed how the two different semen results mirrored the overall semen quality assessment. A total of 199 volunteers participated in the study and delivered two semen samples with an interval of 6 months. The semen parameters were determined according to the World Health Organization (WHO) 1999 guidelines, which were also used to determine whether semen quality was normal or abnormal. In addition, the DNA fragmentation index (DFI) was determined using the Sperm Chromatin Structure Assay. The two samples from each individual were very similar with regard to standard semen parameters and DFI (r(s:) 0.67-0.72), and there were no significant systematic differences between the two samples. The result of the first sample (normal/abnormal) was highly predictive of the overall conclusion based on the two samples (sperm concentration: in 93% of the cases (95% confidence interval [CI]: 89%-96%); sperm motility: in 85% of the cases (95% CI: 79%-89%); overall semen quality: in 85% of the cases (95% CI: 80%-90%). In epidemiological studies, one ejaculate is a sufficient indicator of semen quality in a group of subjects. In a clinical situation, when the question is whether the semen quality is normal or not, the first ejaculate will, in at least 85% of cases, give a correct overall conclusion.},
  author       = {Rylander, Lars and Wetterstrand, Boel and Haugen, Trine B and Malm, Gunilla and Malm, Johan and Bjørsvik, Cathrine and Henrichsen, Trine and Sæther, Thomas and Giwercman, Aleksander},
  issn         = {1008-682X},
  language     = {eng},
  pages        = {723--730},
  publisher    = {Nature Publishing Group},
  series       = {Asian Journal of Andrology},
  title        = {Single semen analysis as a predictor of semen quality: clinical and epidemiological implications.},
  url          = {http://dx.doi.org/10.1038/aja.2009.64},
  volume       = {11},
  year         = {2009},
}