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Complex and context dependent regulation of hematopoiesis by TGF-beta superfamily signaling.

Singbrant, Sofie LU ; Karlsson, Göran LU and Karlsson, Stefan LU (2009) In Annals of the New York Academy of Sciences 1176. p.55-69
Abstract
The transforming growth factor (TGF)-beta superfamily of growth factors, including the TGF-betas, activins, and bone morphogenetic proteins (BMPs), provide cells with a broad spectrum of regulatory signals through the intracellular Smad pathway. Since loss-of-function studies of a majority of the TGF-beta superfamily members result in embryonic lethality, much of our current knowledge of the TGF-beta superfamily's role in hematopoiesis is generated from studies performed in vitro, or in very early stages of embryonic development. TGF-beta is well documented as a potent inhibitor of hematopoietic stem cell (HSC) proliferation in vitro, while its role in vivo is largely unknown. BMP signaling is crucial for the initiation of hematopoiesis in... (More)
The transforming growth factor (TGF)-beta superfamily of growth factors, including the TGF-betas, activins, and bone morphogenetic proteins (BMPs), provide cells with a broad spectrum of regulatory signals through the intracellular Smad pathway. Since loss-of-function studies of a majority of the TGF-beta superfamily members result in embryonic lethality, much of our current knowledge of the TGF-beta superfamily's role in hematopoiesis is generated from studies performed in vitro, or in very early stages of embryonic development. TGF-beta is well documented as a potent inhibitor of hematopoietic stem cell (HSC) proliferation in vitro, while its role in vivo is largely unknown. BMP signaling is crucial for the initiation of hematopoiesis in the developing embryo, although its role in adult hematopoiesis remains elusive. More recently we and others have used conditional knockout models to unravel the role of several components of TGF-beta family signaling in adult hematopoiesis. Here we review the currently known functions for the major factors of this signaling family in embryonic and adult hematopoietic regulation and discuss the context dependency and complexity that permeate this regulation. (Less)
Please use this url to cite or link to this publication:
author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Transforming Growth Factor beta: physiology, Smad Proteins: metabolism, Smad Proteins: genetics, Hematopoietic Stem Cells: physiology, Hematopoiesis: genetics, Hematopoietic Stem Cells: metabolism
in
Annals of the New York Academy of Sciences
volume
1176
pages
55 - 69
publisher
New York Academy of Sciences
external identifiers
  • wos:000271280000006
  • pmid:19796233
  • scopus:70349833632
ISSN
0077-8923
DOI
10.1111/j.1749-6632.2009.04569.x
language
English
LU publication?
yes
id
d7616179-58cf-4b37-8840-1ce7d69725a1 (old id 1500807)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19796233?dopt=Abstract
date added to LUP
2009-11-04 14:13:59
date last changed
2017-05-14 04:29:37
@article{d7616179-58cf-4b37-8840-1ce7d69725a1,
  abstract     = {The transforming growth factor (TGF)-beta superfamily of growth factors, including the TGF-betas, activins, and bone morphogenetic proteins (BMPs), provide cells with a broad spectrum of regulatory signals through the intracellular Smad pathway. Since loss-of-function studies of a majority of the TGF-beta superfamily members result in embryonic lethality, much of our current knowledge of the TGF-beta superfamily's role in hematopoiesis is generated from studies performed in vitro, or in very early stages of embryonic development. TGF-beta is well documented as a potent inhibitor of hematopoietic stem cell (HSC) proliferation in vitro, while its role in vivo is largely unknown. BMP signaling is crucial for the initiation of hematopoiesis in the developing embryo, although its role in adult hematopoiesis remains elusive. More recently we and others have used conditional knockout models to unravel the role of several components of TGF-beta family signaling in adult hematopoiesis. Here we review the currently known functions for the major factors of this signaling family in embryonic and adult hematopoietic regulation and discuss the context dependency and complexity that permeate this regulation.},
  author       = {Singbrant, Sofie and Karlsson, Göran and Karlsson, Stefan},
  issn         = {0077-8923},
  keyword      = {Transforming Growth Factor beta: physiology,Smad Proteins: metabolism,Smad Proteins: genetics,Hematopoietic Stem Cells: physiology,Hematopoiesis: genetics,Hematopoietic Stem Cells: metabolism},
  language     = {eng},
  pages        = {55--69},
  publisher    = {New York Academy of Sciences},
  series       = {Annals of the New York Academy of Sciences},
  title        = {Complex and context dependent regulation of hematopoiesis by TGF-beta superfamily signaling.},
  url          = {http://dx.doi.org/10.1111/j.1749-6632.2009.04569.x},
  volume       = {1176},
  year         = {2009},
}