Skip to main content

Lund University Publications

LUND UNIVERSITY LIBRARIES

Dissection of the genetic complexity of arthritis using animal models.

Holmdahl, Rikard LU (2006) In Immunology Letters 103(2). p.86-91
Abstract
Rheumatoid arthritis (RA) is a chronic inflammatory disease directed towards peripheral joints. As all common diseases it is associated with several genes and a multitude of environmental factors. In addition, in similarity with most other complex diseases, it is defined only on the basis of clinical signs and symptoms, it is therefore more properly classified as a syndrome rather than a distinct disease entity.



This complexity of RA has led to difficulties in finding the underlying genes. In spite of large efforts it is still only the MHC class II region that reaches genome wide significance in confirmed studies. However, this has been known for decades and we are still unable to conclusively identify the underlying... (More)
Rheumatoid arthritis (RA) is a chronic inflammatory disease directed towards peripheral joints. As all common diseases it is associated with several genes and a multitude of environmental factors. In addition, in similarity with most other complex diseases, it is defined only on the basis of clinical signs and symptoms, it is therefore more properly classified as a syndrome rather than a distinct disease entity.



This complexity of RA has led to difficulties in finding the underlying genes. In spite of large efforts it is still only the MHC class II region that reaches genome wide significance in confirmed studies. However, this has been known for decades and we are still unable to conclusively identify the underlying gene/s. We hypothesize that an MHC class II gene is involved and although we have detailed knowledge on both structure and function we do not know its possible pathogenic role in RA.



In this review I will argue for the usefulness of animal models as a tool to identify genes and pathways associated with disease. The examples to be discussed are genes controlling the oxidative burst pathways and MHC class II genes. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
MHC class II, Animal models, Genetics, Arthritis, Oxidative burst
in
Immunology Letters
volume
103
issue
2
pages
86 - 91
publisher
Elsevier
external identifiers
  • wos:000235700000002
  • scopus:31544452514
  • pmid:16413614
ISSN
0165-2478
DOI
10.1016/j.imlet.2005.10.025
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Medical Inflammation Research (013212019)
id
0e2dc0b5-f613-42dd-b6bb-758e5ccee947 (old id 150311)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16413614&dopt=Abstract
date added to LUP
2016-04-01 11:35:36
date last changed
2021-09-22 01:07:14
@article{0e2dc0b5-f613-42dd-b6bb-758e5ccee947,
  abstract     = {Rheumatoid arthritis (RA) is a chronic inflammatory disease directed towards peripheral joints. As all common diseases it is associated with several genes and a multitude of environmental factors. In addition, in similarity with most other complex diseases, it is defined only on the basis of clinical signs and symptoms, it is therefore more properly classified as a syndrome rather than a distinct disease entity.<br/><br>
<br/><br>
This complexity of RA has led to difficulties in finding the underlying genes. In spite of large efforts it is still only the MHC class II region that reaches genome wide significance in confirmed studies. However, this has been known for decades and we are still unable to conclusively identify the underlying gene/s. We hypothesize that an MHC class II gene is involved and although we have detailed knowledge on both structure and function we do not know its possible pathogenic role in RA.<br/><br>
<br/><br>
In this review I will argue for the usefulness of animal models as a tool to identify genes and pathways associated with disease. The examples to be discussed are genes controlling the oxidative burst pathways and MHC class II genes.},
  author       = {Holmdahl, Rikard},
  issn         = {0165-2478},
  language     = {eng},
  number       = {2},
  pages        = {86--91},
  publisher    = {Elsevier},
  series       = {Immunology Letters},
  title        = {Dissection of the genetic complexity of arthritis using animal models.},
  url          = {https://lup.lub.lu.se/search/ws/files/2553102/625262.pdf},
  doi          = {10.1016/j.imlet.2005.10.025},
  volume       = {103},
  year         = {2006},
}