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The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat.

Lane, Emma LU ; Winkler, C ; Brundin, Patrik LU and Cenci Nilsson, Angela LU orcid (2006) In Neurobiology of Disease 22(2). p.334-345
Abstract
Intrastriatal transplants of embryonic ventral mesencephalon can cause dyskinesia in patients with Parkinson's disease (PD). We assessed the impact of transplant size on the development of graft-induced dyskinesia. Rats with unilateral 6-hydroxydopamine lesions were primed to exhibit l-DOPA-induced dyskinesia. They were then intrastriatally grafted with different quantities of embryonic ventral mesencephalic tissue to give small and large grafts. Without drug treatment, discrete dyskinetic-like movements were observed in most rats with large grafts 2–6 weeks after transplantation, but disappeared later. Amphetamine evoked severe abnormal involuntary movements (AIMs) in grafted animals, which were more striking with large grafts. The AIMs... (More)
Intrastriatal transplants of embryonic ventral mesencephalon can cause dyskinesia in patients with Parkinson's disease (PD). We assessed the impact of transplant size on the development of graft-induced dyskinesia. Rats with unilateral 6-hydroxydopamine lesions were primed to exhibit l-DOPA-induced dyskinesia. They were then intrastriatally grafted with different quantities of embryonic ventral mesencephalic tissue to give small and large grafts. Without drug treatment, discrete dyskinetic-like movements were observed in most rats with large grafts 2–6 weeks after transplantation, but disappeared later. Amphetamine evoked severe abnormal involuntary movements (AIMs) in grafted animals, which were more striking with large grafts. The AIMs coincided with contralateral rotation, but displayed a different temporal profile and pharmacological properties. Thus, selective dopamine uptake blockade elicited rotational behavior, whereas coadministration of both dopamine and serotonin uptake blockers was required to evoke significant orolingual and limb AIMs. In conclusion, robust and reproducible AIMs were evoked in rats with large grafts by blockade of monoamine reuptake. These AIMs may provide a new tool for assessing dyskinetic effects of neural grafting. (Less)
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organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
Transplantation, Parkinson's disease, Graft-induced dyskinesia, Amphetamine
in
Neurobiology of Disease
volume
22
issue
2
pages
334 - 345
publisher
Elsevier
external identifiers
  • wos:000237378000013
  • pmid:16406222
  • scopus:33646140789
ISSN
0969-9961
DOI
10.1016/j.nbd.2005.11.011
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Basal Ganglia (013212026), Neuronal Survival (013212041)
id
c0b4b9d7-d7f2-4519-8ab8-bd00203af36c (old id 150412)
alternative location
http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16406222&dopt=Abstract
date added to LUP
2016-04-01 11:49:45
date last changed
2021-06-16 02:02:55
@article{c0b4b9d7-d7f2-4519-8ab8-bd00203af36c,
  abstract     = {Intrastriatal transplants of embryonic ventral mesencephalon can cause dyskinesia in patients with Parkinson's disease (PD). We assessed the impact of transplant size on the development of graft-induced dyskinesia. Rats with unilateral 6-hydroxydopamine lesions were primed to exhibit l-DOPA-induced dyskinesia. They were then intrastriatally grafted with different quantities of embryonic ventral mesencephalic tissue to give small and large grafts. Without drug treatment, discrete dyskinetic-like movements were observed in most rats with large grafts 2–6 weeks after transplantation, but disappeared later. Amphetamine evoked severe abnormal involuntary movements (AIMs) in grafted animals, which were more striking with large grafts. The AIMs coincided with contralateral rotation, but displayed a different temporal profile and pharmacological properties. Thus, selective dopamine uptake blockade elicited rotational behavior, whereas coadministration of both dopamine and serotonin uptake blockers was required to evoke significant orolingual and limb AIMs. In conclusion, robust and reproducible AIMs were evoked in rats with large grafts by blockade of monoamine reuptake. These AIMs may provide a new tool for assessing dyskinetic effects of neural grafting.},
  author       = {Lane, Emma and Winkler, C and Brundin, Patrik and Cenci Nilsson, Angela},
  issn         = {0969-9961},
  language     = {eng},
  number       = {2},
  pages        = {334--345},
  publisher    = {Elsevier},
  series       = {Neurobiology of Disease},
  title        = {The impact of graft size on the development of dyskinesia following intrastriatal grafting of embryonic dopamine neurons in the rat.},
  url          = {http://dx.doi.org/10.1016/j.nbd.2005.11.011},
  doi          = {10.1016/j.nbd.2005.11.011},
  volume       = {22},
  year         = {2006},
}