Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2.
Andersson, Elin LU ; Hebsgaard, Josephine LU ; Parmar, Malin LU
; Guillemot, F
and Björklund, Anders
LU
(2006)
In Development: For advances in developmental biology and stem cells
133(3).
p.507-516
- Abstract
- Neurogenin 2 (Ngn2) is a proneural gene involved in neuronal differentiation and subtype specification in various regions of the nervous system. In the ventral midbrain, Ngn2 is expressed in a spatiotemporal pattern that correlates with the generation of mesencephalic dopaminergic (mesDA) neurons. We show here that lack of Ngn2 impairs the development of mesDA neurons, such that less than half of the normal mesDA neuron number remain in Ngn2 mutant mice at postnatal stages. Analysis of Ngn2 mutant mice during mesDA neurogenesis show that medially located precursors are formed but are arrested in their differentiation at a stage when they have not yet acquired the characteristics of mesDA neuron precursors. Loss of Ngn2 function appears to... (More)
- Neurogenin 2 (Ngn2) is a proneural gene involved in neuronal differentiation and subtype specification in various regions of the nervous system. In the ventral midbrain, Ngn2 is expressed in a spatiotemporal pattern that correlates with the generation of mesencephalic dopaminergic (mesDA) neurons. We show here that lack of Ngn2 impairs the development of mesDA neurons, such that less than half of the normal mesDA neuron number remain in Ngn2 mutant mice at postnatal stages. Analysis of Ngn2 mutant mice during mesDA neurogenesis show that medially located precursors are formed but are arrested in their differentiation at a stage when they have not yet acquired the characteristics of mesDA neuron precursors. Loss of Ngn2 function appears to specifically affect the generation of DA neurons, as the development of other types of neurons within the ventral midbrain is unaltered. Ngn2 is the first example of a gene expressed in progenitors in the ventricular zone of the mesDA neuron domain that is essential for proper mesDA neuron differentiation, and whose loss of function causes impaired mesDA neurogenesis without other major abnormalities in the ventral midbrain. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/150467
- author
- Andersson, Elin
LU
; Hebsgaard, Josephine
LU
; Parmar, Malin
LU
; Guillemot, F
and Björklund, Anders
LU
- organization
- publishing date
- 2006
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Development: For advances in developmental biology and stem cells
- volume
- 133
- issue
- 3
- pages
- 507 - 516
- publisher
- The Company of Biologists Ltd
- external identifiers
-
- wos:000235910500012
- pmid:16396906
- scopus:33244474408
- pmid:16396906
- ISSN
- 1477-9129
- DOI
- 10.1242/dev.02224
- language
- English
- LU publication?
- yes
- id
- 624509c6-a469-4706-af4d-513c6e128426 (old id 150467)
- alternative location
- http://www.ncbi.nlm.nih.gov/entrez/query.fcgi?cmd=Retrieve&db=PubMed&list_uids=16396906&dopt=Abstract
- date added to LUP
- 2016-04-01 11:35:14
- date last changed
- 2022-01-26 07:20:40
@article{624509c6-a469-4706-af4d-513c6e128426,
abstract = {{Neurogenin 2 (Ngn2) is a proneural gene involved in neuronal differentiation and subtype specification in various regions of the nervous system. In the ventral midbrain, Ngn2 is expressed in a spatiotemporal pattern that correlates with the generation of mesencephalic dopaminergic (mesDA) neurons. We show here that lack of Ngn2 impairs the development of mesDA neurons, such that less than half of the normal mesDA neuron number remain in Ngn2 mutant mice at postnatal stages. Analysis of Ngn2 mutant mice during mesDA neurogenesis show that medially located precursors are formed but are arrested in their differentiation at a stage when they have not yet acquired the characteristics of mesDA neuron precursors. Loss of Ngn2 function appears to specifically affect the generation of DA neurons, as the development of other types of neurons within the ventral midbrain is unaltered. Ngn2 is the first example of a gene expressed in progenitors in the ventricular zone of the mesDA neuron domain that is essential for proper mesDA neuron differentiation, and whose loss of function causes impaired mesDA neurogenesis without other major abnormalities in the ventral midbrain.}},
author = {{Andersson, Elin and Hebsgaard, Josephine and Parmar, Malin and Guillemot, F and Björklund, Anders}},
issn = {{1477-9129}},
language = {{eng}},
number = {{3}},
pages = {{507--516}},
publisher = {{The Company of Biologists Ltd}},
series = {{Development: For advances in developmental biology and stem cells}},
title = {{Development of the mesencephalic dopaminergic neuron system is compromised in the absence of neurogenin 2.}},
url = {{http://dx.doi.org/10.1242/dev.02224}},
doi = {{10.1242/dev.02224}},
volume = {{133}},
year = {{2006}},
}