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Contact sensitisation in hand eczema patients-relation to subdiagnosis, severity and quality of life: a multi-centre study

Agner, Tove; Andersen, Klaus Ejner; Brandao, Francisco M.; Bruynzeel, Derk P.; Bruze, Magnus LU ; Frosch, Peter; Goncalo, Margarida; Goossens, An; Le Coz, Christophe J. and Rustemeyer, Thomas, et al. (2009) In Contact Dermatitis 61(5). p.291-296
Abstract
Background Contact sensitisation has been identified as a factor associated with poor prognosis for patients with hand eczema. Objectives To study implications of contact sensitisation with respect to severity, quality of life (QoL) and subdiagnosis of hand eczema. Methods The study was performed as a multi-centre, cross-sectional study from 10 European clinics. All patients were patch tested, and severity of hand eczema assessed by Hand Eczema Severity Index. A multi-variate analysis was performed to explore which factors influenced severity, QoL and sick leave. Results A total 416 patients were included, and 63% had contact sensitisation to one or more of the tested allergens. More women (66%) than men (51%) were sensitized. No... (More)
Background Contact sensitisation has been identified as a factor associated with poor prognosis for patients with hand eczema. Objectives To study implications of contact sensitisation with respect to severity, quality of life (QoL) and subdiagnosis of hand eczema. Methods The study was performed as a multi-centre, cross-sectional study from 10 European clinics. All patients were patch tested, and severity of hand eczema assessed by Hand Eczema Severity Index. A multi-variate analysis was performed to explore which factors influenced severity, QoL and sick leave. Results A total 416 patients were included, and 63% had contact sensitisation to one or more of the tested allergens. More women (66%) than men (51%) were sensitized. No significant association was found between sensitisation to specific allergens, disease severity, QoL or diagnostic subgroups. High age, male sex, atopic eczema and presence of contact sensitisation were independent risk factors for increased severity as measured by Hand Eczema Severity Index. Furthermore, the severity of hand eczema increased by the number of contact sensitisations detected (P = 0.023). High age and personal history of atopic eczema were independent risk factors for low QoL, as measured by Dermatology Life Quality Index, and atopic eczema as well as allergic contact dermatitis as subdiagnosis was associated with increased sick leave. Conclusion Diagnostic subgroups were not found to be related to specific allergens. Contact sensitisation was found to be a risk factor for increased severity of hand eczema, as did high age, male sex and atopic eczema. (Less)
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publication status
published
subject
keywords
contact sensitisation, hand eczema, HandEczema Severity Index, QoL
in
Contact Dermatitis
volume
61
issue
5
pages
291 - 296
publisher
Federation of European Neuroscience Societies and Blackwell Publishing Ltd
external identifiers
  • wos:000271264300007
  • scopus:70350506106
ISSN
0105-1873
language
English
LU publication?
yes
id
06dc6bb1-c756-478a-89f0-ac18a32442a0 (old id 1505163)
date added to LUP
2009-11-24 14:05:16
date last changed
2017-11-05 03:31:51
@article{06dc6bb1-c756-478a-89f0-ac18a32442a0,
  abstract     = {Background Contact sensitisation has been identified as a factor associated with poor prognosis for patients with hand eczema. Objectives To study implications of contact sensitisation with respect to severity, quality of life (QoL) and subdiagnosis of hand eczema. Methods The study was performed as a multi-centre, cross-sectional study from 10 European clinics. All patients were patch tested, and severity of hand eczema assessed by Hand Eczema Severity Index. A multi-variate analysis was performed to explore which factors influenced severity, QoL and sick leave. Results A total 416 patients were included, and 63% had contact sensitisation to one or more of the tested allergens. More women (66%) than men (51%) were sensitized. No significant association was found between sensitisation to specific allergens, disease severity, QoL or diagnostic subgroups. High age, male sex, atopic eczema and presence of contact sensitisation were independent risk factors for increased severity as measured by Hand Eczema Severity Index. Furthermore, the severity of hand eczema increased by the number of contact sensitisations detected (P = 0.023). High age and personal history of atopic eczema were independent risk factors for low QoL, as measured by Dermatology Life Quality Index, and atopic eczema as well as allergic contact dermatitis as subdiagnosis was associated with increased sick leave. Conclusion Diagnostic subgroups were not found to be related to specific allergens. Contact sensitisation was found to be a risk factor for increased severity of hand eczema, as did high age, male sex and atopic eczema.},
  author       = {Agner, Tove and Andersen, Klaus Ejner and Brandao, Francisco M. and Bruynzeel, Derk P. and Bruze, Magnus and Frosch, Peter and Goncalo, Margarida and Goossens, An and Le Coz, Christophe J. and Rustemeyer, Thomas and White, Ian R. and Diepgen, Thomas},
  issn         = {0105-1873},
  keyword      = {contact sensitisation,hand eczema,HandEczema Severity Index,QoL},
  language     = {eng},
  number       = {5},
  pages        = {291--296},
  publisher    = {Federation of European Neuroscience Societies and Blackwell Publishing Ltd},
  series       = {Contact Dermatitis},
  title        = {Contact sensitisation in hand eczema patients-relation to subdiagnosis, severity and quality of life: a multi-centre study},
  volume       = {61},
  year         = {2009},
}