Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation
(2009) In Nature Immunology 10(11). p.78-1193- Abstract
- The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled... (More)
- The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons. (Less)
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https://lup.lub.lu.se/record/1506008
- author
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nature Immunology
- volume
- 10
- issue
- 11
- pages
- 78 - 1193
- publisher
- Nature Publishing Group
- external identifiers
-
- wos:000270955900012
- scopus:70350447216
- pmid:19783990
- ISSN
- 1529-2908
- DOI
- 10.1038/ni.1789
- language
- English
- LU publication?
- yes
- id
- 6706bf18-07fb-47c7-86f7-22145ffd35b4 (old id 1506008)
- date added to LUP
- 2016-04-01 14:37:05
- date last changed
- 2022-04-22 04:07:53
@article{6706bf18-07fb-47c7-86f7-22145ffd35b4,
abstract = {{The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons.}},
author = {{van de Pavert, Serge A. and Olivier, Brenda J. and Goverse, Gera and Vondenhoff, Mark F. and Greuter, Mascha and Beke, Patrick and Kusser, Kim and Hoepken, Uta E. and Lipp, Martin and Niederreither, Karen and Blomhoff, Rune and Sitnik, Katarzyna and Agace, William and Randall, Troy D. and de Jonge, Wouter J. and Mebius, Reina E.}},
issn = {{1529-2908}},
language = {{eng}},
number = {{11}},
pages = {{78--1193}},
publisher = {{Nature Publishing Group}},
series = {{Nature Immunology}},
title = {{Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation}},
url = {{http://dx.doi.org/10.1038/ni.1789}},
doi = {{10.1038/ni.1789}},
volume = {{10}},
year = {{2009}},
}