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Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation

van de Pavert, Serge A.; Olivier, Brenda J.; Goverse, Gera; Vondenhoff, Mark F.; Greuter, Mascha; Beke, Patrick; Kusser, Kim; Hoepken, Uta E.; Lipp, Martin and Niederreither, Karen, et al. (2009) In Nature Immunology 10(11). p.78-1193
Abstract
The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled... (More)
The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons. (Less)
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Contribution to journal
publication status
published
subject
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Nature Immunology
volume
10
issue
11
pages
78 - 1193
publisher
Nature Publishing Group
external identifiers
  • wos:000270955900012
  • scopus:70350447216
ISSN
1529-2908
DOI
10.1038/ni.1789
language
English
LU publication?
yes
id
6706bf18-07fb-47c7-86f7-22145ffd35b4 (old id 1506008)
date added to LUP
2009-11-23 16:35:02
date last changed
2017-10-29 04:02:57
@article{6706bf18-07fb-47c7-86f7-22145ffd35b4,
  abstract     = {The location of embryonic lymph node development is determined by the initial clustering of lymphoid tissue-inducer (LTi) cells. Here we demonstrate that both the chemokine CXCL13 and the chemokine CCL21 attracted LTi cells at embryonic days 12.5-14.5 and that initial clustering depended exclusively on CXCL13. Retinoic acid (RA) induced early CXCL13 expression in stromal organizer cells independently of lymphotoxin signaling. Notably, neurons adjacent to the lymph node anlagen expressed enzymes essential for RA synthesis. Furthermore, stimulation of parasymphathetic neural output in adults led to RA receptor (RAR)-dependent induction of CXCL13 in the gut. Therefore, our data show that the initiation of lymph node development is controlled by RA-mediated expression of CXCL13 and suggest that RA may be provided by adjacent neurons.},
  author       = {van de Pavert, Serge A. and Olivier, Brenda J. and Goverse, Gera and Vondenhoff, Mark F. and Greuter, Mascha and Beke, Patrick and Kusser, Kim and Hoepken, Uta E. and Lipp, Martin and Niederreither, Karen and Blomhoff, Rune and Sitnik, Katarzyna and Agace, William and Randall, Troy D. and de Jonge, Wouter J. and Mebius, Reina E.},
  issn         = {1529-2908},
  language     = {eng},
  number       = {11},
  pages        = {78--1193},
  publisher    = {Nature Publishing Group},
  series       = {Nature Immunology},
  title        = {Chemokine CXCL13 is essential for lymph node initiation and is induced by retinoic acid and neuronal stimulation},
  url          = {http://dx.doi.org/10.1038/ni.1789},
  volume       = {10},
  year         = {2009},
}