Advanced

Complement Cascade in Systemic Lupus Erythematosus Analyses of the Three Activation Pathways

Ceribelli, Angela; Andreoli, Laura; Cavazzana, Ilaria; Franceschini, Franco; Radice, Antonella; Rimoldi, Laura; Sinico, Renato Alberto; Carlsson, Malin LU ; Wieslander, Jorgen and Tincani, Angela (2009) 6th International Congress on Autoimmunity In Contemporary Challenges in Autoimmunity 1173. p.427-434
Abstract
The complement (C') cascade is an important part of the innate immunity. It acts through three major pathways: classical (CP), alternative (AP) and mannose-binding-lectin (MP). C' reduction is a key feature in systemic lupus erythematosus (SLE), for its pathogenesis and for disease relapse. The aims of our study are to correlate C' variations with disease activity and verify the presence of C' deficiencies. We tested for three C' pathways 52 sera from 20 patients affected by SLE. A significant correlation between the ECLAM score and the degree of activation of the CP (Mann-Whitney; P = 0.001) was recorded, while the correlation with anti-dsDNA antibodies did not reach statistical significance (Mann-Whitney; P > 0.05). In conclusion, the... (More)
The complement (C') cascade is an important part of the innate immunity. It acts through three major pathways: classical (CP), alternative (AP) and mannose-binding-lectin (MP). C' reduction is a key feature in systemic lupus erythematosus (SLE), for its pathogenesis and for disease relapse. The aims of our study are to correlate C' variations with disease activity and verify the presence of C' deficiencies. We tested for three C' pathways 52 sera from 20 patients affected by SLE. A significant correlation between the ECLAM score and the degree of activation of the CP (Mann-Whitney; P = 0.001) was recorded, while the correlation with anti-dsDNA antibodies did not reach statistical significance (Mann-Whitney; P > 0.05). In conclusion, the ELISA assay can be considered well suited for testing SLE samples. We detected a significant link between the phases of lupus activity and the reduction of the CP. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
complement deficiency, complement pathways, ELISA kit, complement, complement (C') cascade, systemic lupus erythematosus (SLE)
in
Contemporary Challenges in Autoimmunity
volume
1173
pages
427 - 434
publisher
Wiley-Blackwell
conference name
6th International Congress on Autoimmunity
external identifiers
  • wos:000270762800060
  • scopus:69949168408
ISSN
0077-8923
DOI
10.1111/j.1749-6632.2009.04921.x
language
English
LU publication?
yes
id
df00e99e-b941-47b4-a854-fceaccedf112 (old id 1507017)
date added to LUP
2009-11-23 12:56:45
date last changed
2017-05-28 04:07:04
@inproceedings{df00e99e-b941-47b4-a854-fceaccedf112,
  abstract     = {The complement (C') cascade is an important part of the innate immunity. It acts through three major pathways: classical (CP), alternative (AP) and mannose-binding-lectin (MP). C' reduction is a key feature in systemic lupus erythematosus (SLE), for its pathogenesis and for disease relapse. The aims of our study are to correlate C' variations with disease activity and verify the presence of C' deficiencies. We tested for three C' pathways 52 sera from 20 patients affected by SLE. A significant correlation between the ECLAM score and the degree of activation of the CP (Mann-Whitney; P = 0.001) was recorded, while the correlation with anti-dsDNA antibodies did not reach statistical significance (Mann-Whitney; P > 0.05). In conclusion, the ELISA assay can be considered well suited for testing SLE samples. We detected a significant link between the phases of lupus activity and the reduction of the CP.},
  author       = {Ceribelli, Angela and Andreoli, Laura and Cavazzana, Ilaria and Franceschini, Franco and Radice, Antonella and Rimoldi, Laura and Sinico, Renato Alberto and Carlsson, Malin and Wieslander, Jorgen and Tincani, Angela},
  booktitle    = {Contemporary Challenges in Autoimmunity},
  issn         = {0077-8923},
  keyword      = {complement deficiency,complement pathways,ELISA kit,complement,complement (C') cascade,systemic lupus erythematosus (SLE)},
  language     = {eng},
  pages        = {427--434},
  publisher    = {Wiley-Blackwell},
  title        = {Complement Cascade in Systemic Lupus Erythematosus Analyses of the Three Activation Pathways},
  url          = {http://dx.doi.org/10.1111/j.1749-6632.2009.04921.x},
  volume       = {1173},
  year         = {2009},
}