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Ankylosing Spondylitis Susceptibility and Severity-Contribution of TNF Gene Promoter Polymorphisms at Positions-238 and-308

Sousa, Elsa; Caetano-Lopes, Joana; Pinto, Patricia; Pimentel, Fernando; Teles, José LU ; Canhao, Helena; Rodrigues, Ana; Resende, Catarina; Mourao, Ana Filipa and Ribeiro, Celia, et al. (2009) 6th International Congress on Autoimmunity In Contemporary Challenges in Autoimmunity 1173. p.581-588
Abstract
Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on AS susceptibility and prognosis. SNPS were determined by restriction fragment length polymorphisms in patients and controls. AS patients exhibited a decreased frequency of the A allele at position -238 (10%) when compared with controls (18%), suggesting that this could be a protective factor for disease susceptibility. In addition, the -308 GA/AA... (More)
Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on AS susceptibility and prognosis. SNPS were determined by restriction fragment length polymorphisms in patients and controls. AS patients exhibited a decreased frequency of the A allele at position -238 (10%) when compared with controls (18%), suggesting that this could be a protective factor for disease susceptibility. In addition, the -308 GA/AA genotypes were associated with later disease onset in AS patients. These results suggest that TNF gene promoter polymorphisms at positions -238 and -308 could have a small influence on AS susceptibility and prognosis. (Less)
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organization
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type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
susceptibility, ankylosing spondylitis, TNF promoter polymorphisms, prognosis
in
Contemporary Challenges in Autoimmunity
volume
1173
pages
581 - 588
publisher
Wiley-Blackwell
conference name
6th International Congress on Autoimmunity
external identifiers
  • wos:000270762800081
  • scopus:70049086655
ISSN
0077-8923
DOI
10.1111/j.1749-6632.2009.04758.x
language
English
LU publication?
yes
id
2b6c3cd1-f5e0-4ab9-aab1-3d908b2ed3c0 (old id 1507029)
date added to LUP
2009-11-23 12:58:07
date last changed
2017-01-01 05:48:56
@inproceedings{2b6c3cd1-f5e0-4ab9-aab1-3d908b2ed3c0,
  abstract     = {Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on AS susceptibility and prognosis. SNPS were determined by restriction fragment length polymorphisms in patients and controls. AS patients exhibited a decreased frequency of the A allele at position -238 (10%) when compared with controls (18%), suggesting that this could be a protective factor for disease susceptibility. In addition, the -308 GA/AA genotypes were associated with later disease onset in AS patients. These results suggest that TNF gene promoter polymorphisms at positions -238 and -308 could have a small influence on AS susceptibility and prognosis.},
  author       = {Sousa, Elsa and Caetano-Lopes, Joana and Pinto, Patricia and Pimentel, Fernando and Teles, José and Canhao, Helena and Rodrigues, Ana and Resende, Catarina and Mourao, Ana Filipa and Ribeiro, Celia and Pinto, Teresa Laura and Rosa, Carlos Miranda and Pereira da Silva, Jose Alberto and Branco, Jaime and Ventura, Francisco and Queiroz, Mario Viana and Fonseca, Joao Eurico},
  booktitle    = {Contemporary Challenges in Autoimmunity},
  issn         = {0077-8923},
  keyword      = {susceptibility,ankylosing spondylitis,TNF promoter polymorphisms,prognosis},
  language     = {eng},
  pages        = {581--588},
  publisher    = {Wiley-Blackwell},
  title        = {Ankylosing Spondylitis Susceptibility and Severity-Contribution of TNF Gene Promoter Polymorphisms at Positions-238 and-308},
  url          = {http://dx.doi.org/10.1111/j.1749-6632.2009.04758.x},
  volume       = {1173},
  year         = {2009},
}