Ankylosing Spondylitis Susceptibility and Severity-Contribution of TNF Gene Promoter Polymorphisms at Positions-238 and-308
(2009) 6th International Congress on Autoimmunity 1173. p.581-588- Abstract
- Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on AS susceptibility and prognosis. SNPS were determined by restriction fragment length polymorphisms in patients and controls. AS patients exhibited a decreased frequency of the A allele at position -238 (10%) when compared with controls (18%), suggesting that this could be a protective factor for disease susceptibility. In addition, the -308 GA/AA... (More)
- Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on AS susceptibility and prognosis. SNPS were determined by restriction fragment length polymorphisms in patients and controls. AS patients exhibited a decreased frequency of the A allele at position -238 (10%) when compared with controls (18%), suggesting that this could be a protective factor for disease susceptibility. In addition, the -308 GA/AA genotypes were associated with later disease onset in AS patients. These results suggest that TNF gene promoter polymorphisms at positions -238 and -308 could have a small influence on AS susceptibility and prognosis. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1507029
- author
- organization
- publishing date
- 2009
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- susceptibility, ankylosing spondylitis, TNF promoter polymorphisms, prognosis
- host publication
- Contemporary Challenges in Autoimmunity
- volume
- 1173
- pages
- 581 - 588
- publisher
- Wiley-Blackwell
- conference name
- 6th International Congress on Autoimmunity
- conference location
- Oporto, Portugal
- conference dates
- 2008-09-10 - 2008-09-14
- external identifiers
-
- wos:000270762800081
- scopus:70049086655
- pmid:19758203
- ISSN
- 0077-8923
- DOI
- 10.1111/j.1749-6632.2009.04758.x
- language
- English
- LU publication?
- yes
- id
- 2b6c3cd1-f5e0-4ab9-aab1-3d908b2ed3c0 (old id 1507029)
- date added to LUP
- 2016-04-01 13:41:03
- date last changed
- 2024-01-09 16:52:01
@inproceedings{2b6c3cd1-f5e0-4ab9-aab1-3d908b2ed3c0, abstract = {{Ankylosing spondylitis (AS) is a chronic inflammatory disease in which genetic factors play a central role. The efficacy of TNF blockers has reoriented research in this field in order to explain the influence of TNF in AS pathogenesis. The objective of this study was to access the influence of single nucleotide polymorphisms (SNPs) at positions -308 and -238 of the promoter region of TNF gene on AS susceptibility and prognosis. SNPS were determined by restriction fragment length polymorphisms in patients and controls. AS patients exhibited a decreased frequency of the A allele at position -238 (10%) when compared with controls (18%), suggesting that this could be a protective factor for disease susceptibility. In addition, the -308 GA/AA genotypes were associated with later disease onset in AS patients. These results suggest that TNF gene promoter polymorphisms at positions -238 and -308 could have a small influence on AS susceptibility and prognosis.}}, author = {{Sousa, Elsa and Caetano-Lopes, Joana and Pinto, Patricia and Pimentel, Fernando and Teles, José and Canhao, Helena and Rodrigues, Ana and Resende, Catarina and Mourao, Ana Filipa and Ribeiro, Celia and Pinto, Teresa Laura and Rosa, Carlos Miranda and Pereira da Silva, Jose Alberto and Branco, Jaime and Ventura, Francisco and Queiroz, Mario Viana and Fonseca, Joao Eurico}}, booktitle = {{Contemporary Challenges in Autoimmunity}}, issn = {{0077-8923}}, keywords = {{susceptibility; ankylosing spondylitis; TNF promoter polymorphisms; prognosis}}, language = {{eng}}, pages = {{581--588}}, publisher = {{Wiley-Blackwell}}, title = {{Ankylosing Spondylitis Susceptibility and Severity-Contribution of TNF Gene Promoter Polymorphisms at Positions-238 and-308}}, url = {{http://dx.doi.org/10.1111/j.1749-6632.2009.04758.x}}, doi = {{10.1111/j.1749-6632.2009.04758.x}}, volume = {{1173}}, year = {{2009}}, }