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Antitreponemal Antibodies Leading to Autoantibody Production and Protection from Atherosclerosis in Kitavans from Papua New Guinea

Agmon-Levin, Nancy; Bat-sheva, Porat Katz; Barzilai, Ori; Ram, Maya; Lindeberg, Staffan LU ; Frostegard, Johan and Shoenfeld, Yehuda (2009) 6th International Congress on Autoimmunity In Contemporary Challenges in Autoimmunity 1173. p.675-682
Abstract
The objective of our study was to determine the prevalence of anti-infectious agent antibodies and autoantibodies in a unique non-Westernized population from Kitava, Papua New Guinea (PNG), compared to Western populations. We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti-infectious agent antibodies (treponema, toxoplsmosis, Epstein-Barr virus, cytomegalovirus, rubella) and autoantiobodies [anti-double-stranded (ds)DNA, anti-chromatin, anti-ribonucleoprotein (RNP), anti-SSB, anti-SSA, anti-Scl-70, anti-Smith, anti-centromer, anti-SmRNP, anti-Jo-1, and anti-ribosomal-P] using the Bio-Rad BioPlex 2200. Antitreponemal antibodies were detected in 87% of PNG... (More)
The objective of our study was to determine the prevalence of anti-infectious agent antibodies and autoantibodies in a unique non-Westernized population from Kitava, Papua New Guinea (PNG), compared to Western populations. We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti-infectious agent antibodies (treponema, toxoplsmosis, Epstein-Barr virus, cytomegalovirus, rubella) and autoantiobodies [anti-double-stranded (ds)DNA, anti-chromatin, anti-ribonucleoprotein (RNP), anti-SSB, anti-SSA, anti-Scl-70, anti-Smith, anti-centromer, anti-SmRNP, anti-Jo-1, and anti-ribosomal-P] using the Bio-Rad BioPlex 2200. Antitreponemal antibodies were detected in 87% of PNG sera versus 0-6% of controls (P < 0.0001). Anti-dsDNA antibodies were detected in 31% of PNG samples, which was significantly higher than in three of the control groups (<10%). The outstanding high rate of antitreponemal antibodies detected in Kitavans possibly represents prior yaws disease. A low prevalence of cardiovascular disease was previously documented in Kitavans and has been attributed, in addition to their diet, to the high prevalence of natural cardioprotective autoantibodies (the IgM-antiphosphorylcholine antibodies) in this population. Treponemal infection has been shown to induce the appearance of antiphosphorylcholine antibodies. These protective autoantibodies may cross-react with the pathogenic anti-dsDNA antibodies. Thus, it is suggested that infection with treponema is associated with the presence of protective as well as pathogenic autoantibodies. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Chapter in Book/Report/Conference proceeding
publication status
published
subject
keywords
autoantibodies, atherosclerosis, antiphosphorylcholine antibodies, treponema, Papua New Guinea, Kitava, yaws disease
in
Contemporary Challenges in Autoimmunity
volume
1173
pages
675 - 682
publisher
Wiley-Blackwell
conference name
6th International Congress on Autoimmunity
external identifiers
  • wos:000270762800093
  • scopus:69949174755
ISSN
0077-8923
DOI
10.1111/j.1749-6632.2009.04671.x
language
English
LU publication?
yes
id
59d55fdb-f707-422a-b4bf-b5e2ec05e91d (old id 1507052)
date added to LUP
2009-11-23 10:25:10
date last changed
2017-01-08 04:23:26
@inproceedings{59d55fdb-f707-422a-b4bf-b5e2ec05e91d,
  abstract     = {The objective of our study was to determine the prevalence of anti-infectious agent antibodies and autoantibodies in a unique non-Westernized population from Kitava, Papua New Guinea (PNG), compared to Western populations. We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti-infectious agent antibodies (treponema, toxoplsmosis, Epstein-Barr virus, cytomegalovirus, rubella) and autoantiobodies [anti-double-stranded (ds)DNA, anti-chromatin, anti-ribonucleoprotein (RNP), anti-SSB, anti-SSA, anti-Scl-70, anti-Smith, anti-centromer, anti-SmRNP, anti-Jo-1, and anti-ribosomal-P] using the Bio-Rad BioPlex 2200. Antitreponemal antibodies were detected in 87% of PNG sera versus 0-6% of controls (P &lt; 0.0001). Anti-dsDNA antibodies were detected in 31% of PNG samples, which was significantly higher than in three of the control groups (&lt;10%). The outstanding high rate of antitreponemal antibodies detected in Kitavans possibly represents prior yaws disease. A low prevalence of cardiovascular disease was previously documented in Kitavans and has been attributed, in addition to their diet, to the high prevalence of natural cardioprotective autoantibodies (the IgM-antiphosphorylcholine antibodies) in this population. Treponemal infection has been shown to induce the appearance of antiphosphorylcholine antibodies. These protective autoantibodies may cross-react with the pathogenic anti-dsDNA antibodies. Thus, it is suggested that infection with treponema is associated with the presence of protective as well as pathogenic autoantibodies.},
  author       = {Agmon-Levin, Nancy and Bat-sheva, Porat Katz and Barzilai, Ori and Ram, Maya and Lindeberg, Staffan and Frostegard, Johan and Shoenfeld, Yehuda},
  booktitle    = {Contemporary Challenges in Autoimmunity},
  issn         = {0077-8923},
  keyword      = {autoantibodies,atherosclerosis,antiphosphorylcholine antibodies,treponema,Papua New Guinea,Kitava,yaws disease},
  language     = {eng},
  pages        = {675--682},
  publisher    = {Wiley-Blackwell},
  title        = {Antitreponemal Antibodies Leading to Autoantibody Production and Protection from Atherosclerosis in Kitavans from Papua New Guinea},
  url          = {http://dx.doi.org/10.1111/j.1749-6632.2009.04671.x},
  volume       = {1173},
  year         = {2009},
}