Antitreponemal Antibodies Leading to Autoantibody Production and Protection from Atherosclerosis in Kitavans from Papua New Guinea
(2009) 6th International Congress on Autoimmunity 1173. p.675-682- Abstract
- The objective of our study was to determine the prevalence of anti-infectious agent antibodies and autoantibodies in a unique non-Westernized population from Kitava, Papua New Guinea (PNG), compared to Western populations. We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti-infectious agent antibodies (treponema, toxoplsmosis, Epstein-Barr virus, cytomegalovirus, rubella) and autoantiobodies [anti-double-stranded (ds)DNA, anti-chromatin, anti-ribonucleoprotein (RNP), anti-SSB, anti-SSA, anti-Scl-70, anti-Smith, anti-centromer, anti-SmRNP, anti-Jo-1, and anti-ribosomal-P] using the Bio-Rad BioPlex 2200. Antitreponemal antibodies were detected in 87% of PNG... (More)
- The objective of our study was to determine the prevalence of anti-infectious agent antibodies and autoantibodies in a unique non-Westernized population from Kitava, Papua New Guinea (PNG), compared to Western populations. We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti-infectious agent antibodies (treponema, toxoplsmosis, Epstein-Barr virus, cytomegalovirus, rubella) and autoantiobodies [anti-double-stranded (ds)DNA, anti-chromatin, anti-ribonucleoprotein (RNP), anti-SSB, anti-SSA, anti-Scl-70, anti-Smith, anti-centromer, anti-SmRNP, anti-Jo-1, and anti-ribosomal-P] using the Bio-Rad BioPlex 2200. Antitreponemal antibodies were detected in 87% of PNG sera versus 0-6% of controls (P < 0.0001). Anti-dsDNA antibodies were detected in 31% of PNG samples, which was significantly higher than in three of the control groups (<10%). The outstanding high rate of antitreponemal antibodies detected in Kitavans possibly represents prior yaws disease. A low prevalence of cardiovascular disease was previously documented in Kitavans and has been attributed, in addition to their diet, to the high prevalence of natural cardioprotective autoantibodies (the IgM-antiphosphorylcholine antibodies) in this population. Treponemal infection has been shown to induce the appearance of antiphosphorylcholine antibodies. These protective autoantibodies may cross-react with the pathogenic anti-dsDNA antibodies. Thus, it is suggested that infection with treponema is associated with the presence of protective as well as pathogenic autoantibodies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1507052
- author
- Agmon-Levin, Nancy ; Bat-sheva, Porat Katz ; Barzilai, Ori ; Ram, Maya ; Lindeberg, Staffan LU ; Frostegard, Johan and Shoenfeld, Yehuda
- organization
- publishing date
- 2009
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- keywords
- autoantibodies, atherosclerosis, antiphosphorylcholine antibodies, treponema, Papua New Guinea, Kitava, yaws disease
- host publication
- Contemporary Challenges in Autoimmunity
- volume
- 1173
- pages
- 675 - 682
- publisher
- Wiley-Blackwell
- conference name
- 6th International Congress on Autoimmunity
- conference location
- Oporto, Portugal
- conference dates
- 2008-09-10 - 2008-09-14
- external identifiers
-
- wos:000270762800093
- scopus:69949174755
- pmid:19758215
- ISSN
- 0077-8923
- DOI
- 10.1111/j.1749-6632.2009.04671.x
- language
- English
- LU publication?
- yes
- id
- 59d55fdb-f707-422a-b4bf-b5e2ec05e91d (old id 1507052)
- date added to LUP
- 2016-04-01 13:20:33
- date last changed
- 2024-01-09 12:14:46
@inproceedings{59d55fdb-f707-422a-b4bf-b5e2ec05e91d,
abstract = {{The objective of our study was to determine the prevalence of anti-infectious agent antibodies and autoantibodies in a unique non-Westernized population from Kitava, Papua New Guinea (PNG), compared to Western populations. We matched 120 serum samples from Kitavans with 437 samples from four healthy control groups. Sera were tested for the presence of anti-infectious agent antibodies (treponema, toxoplsmosis, Epstein-Barr virus, cytomegalovirus, rubella) and autoantiobodies [anti-double-stranded (ds)DNA, anti-chromatin, anti-ribonucleoprotein (RNP), anti-SSB, anti-SSA, anti-Scl-70, anti-Smith, anti-centromer, anti-SmRNP, anti-Jo-1, and anti-ribosomal-P] using the Bio-Rad BioPlex 2200. Antitreponemal antibodies were detected in 87% of PNG sera versus 0-6% of controls (P < 0.0001). Anti-dsDNA antibodies were detected in 31% of PNG samples, which was significantly higher than in three of the control groups (<10%). The outstanding high rate of antitreponemal antibodies detected in Kitavans possibly represents prior yaws disease. A low prevalence of cardiovascular disease was previously documented in Kitavans and has been attributed, in addition to their diet, to the high prevalence of natural cardioprotective autoantibodies (the IgM-antiphosphorylcholine antibodies) in this population. Treponemal infection has been shown to induce the appearance of antiphosphorylcholine antibodies. These protective autoantibodies may cross-react with the pathogenic anti-dsDNA antibodies. Thus, it is suggested that infection with treponema is associated with the presence of protective as well as pathogenic autoantibodies.}},
author = {{Agmon-Levin, Nancy and Bat-sheva, Porat Katz and Barzilai, Ori and Ram, Maya and Lindeberg, Staffan and Frostegard, Johan and Shoenfeld, Yehuda}},
booktitle = {{Contemporary Challenges in Autoimmunity}},
issn = {{0077-8923}},
keywords = {{autoantibodies; atherosclerosis; antiphosphorylcholine antibodies; treponema; Papua New Guinea; Kitava; yaws disease}},
language = {{eng}},
pages = {{675--682}},
publisher = {{Wiley-Blackwell}},
title = {{Antitreponemal Antibodies Leading to Autoantibody Production and Protection from Atherosclerosis in Kitavans from Papua New Guinea}},
url = {{http://dx.doi.org/10.1111/j.1749-6632.2009.04671.x}},
doi = {{10.1111/j.1749-6632.2009.04671.x}},
volume = {{1173}},
year = {{2009}},
}