Lipid metabolites as regulators of airway smooth muscle function
Clarke, Deborah L. ; Dakshinamurti, Shyamala ; Larsson Callerfelt, Anna-Karin LU
; Ward, Jane E.
and Yamasaki, Akira
(2009)
In Pulmonary Pharmacology & Therapeutics
22(5).
p.426-435
- Abstract
- Compelling evidence identifies airway smooth muscle (ASM) not only as a target but also a cellular source for a diverse range of mediators underlying the processes of airway narrowing and airway hyperresponsiveness in diseases such as asthma. These include the growing family of plasma membrane phospholipid-derived polyunsaturated fatty acids broadly characterised by the prostaglandins, leukotrienes, lipoxins, isoprostanes and lysophospholipids. In this review, we describe the enzymatic and nonenzymatic biosynthetic pathways of these lipid mediators and how these are influenced by drug treatment, oxidative stress and airways disease. Additionally, we outline their cognate receptors, many of which are expressed by ASM. We describe potential... (More)
- Compelling evidence identifies airway smooth muscle (ASM) not only as a target but also a cellular source for a diverse range of mediators underlying the processes of airway narrowing and airway hyperresponsiveness in diseases such as asthma. These include the growing family of plasma membrane phospholipid-derived polyunsaturated fatty acids broadly characterised by the prostaglandins, leukotrienes, lipoxins, isoprostanes and lysophospholipids. In this review, we describe the enzymatic and nonenzymatic biosynthetic pathways of these lipid mediators and how these are influenced by drug treatment, oxidative stress and airways disease. Additionally, we outline their cognate receptors, many of which are expressed by ASM. We describe potential deleterious and protective roles for these lipid mediators in airway inflammatory and remodelling processes by describing their effects on diverse functions of ASM in asthma that have the potential to contribute to asthma pathogenesis and symptoms. These functions include contractile tone development cytokine and extracellular matrix production, and cellular proliferation and migration. (C) 2008 Elsevier Ltd. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1507248
- author
- Clarke, Deborah L.
; Dakshinamurti, Shyamala
; Larsson Callerfelt, Anna-Karin
LU
; Ward, Jane E.
and Yamasaki, Akira
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- keywords
- Proliferation, Contraction, Lysophospholipid, Isoprostane, Leukotriene, Airway smooth muscle, Prostanoid, Migration, Inflammation
- in
- Pulmonary Pharmacology & Therapeutics
- volume
- 22
- issue
- 5
- pages
- 426 - 435
- publisher
- Elsevier
- external identifiers
-
- wos:000270636200011
- scopus:69249224457
- pmid:19114116
- ISSN
- 1522-9629
- DOI
- 10.1016/j.pupt.2008.12.003
- language
- English
- LU publication?
- yes
- id
- c4edf562-ad3b-482f-9551-8b7a67d86661 (old id 1507248)
- date added to LUP
- 2016-04-01 13:36:31
- date last changed
- 2025-04-04 14:05:52
@article{c4edf562-ad3b-482f-9551-8b7a67d86661,
abstract = {{Compelling evidence identifies airway smooth muscle (ASM) not only as a target but also a cellular source for a diverse range of mediators underlying the processes of airway narrowing and airway hyperresponsiveness in diseases such as asthma. These include the growing family of plasma membrane phospholipid-derived polyunsaturated fatty acids broadly characterised by the prostaglandins, leukotrienes, lipoxins, isoprostanes and lysophospholipids. In this review, we describe the enzymatic and nonenzymatic biosynthetic pathways of these lipid mediators and how these are influenced by drug treatment, oxidative stress and airways disease. Additionally, we outline their cognate receptors, many of which are expressed by ASM. We describe potential deleterious and protective roles for these lipid mediators in airway inflammatory and remodelling processes by describing their effects on diverse functions of ASM in asthma that have the potential to contribute to asthma pathogenesis and symptoms. These functions include contractile tone development cytokine and extracellular matrix production, and cellular proliferation and migration. (C) 2008 Elsevier Ltd. All rights reserved.}},
author = {{Clarke, Deborah L. and Dakshinamurti, Shyamala and Larsson Callerfelt, Anna-Karin and Ward, Jane E. and Yamasaki, Akira}},
issn = {{1522-9629}},
keywords = {{Proliferation; Contraction; Lysophospholipid; Isoprostane; Leukotriene; Airway smooth muscle; Prostanoid; Migration; Inflammation}},
language = {{eng}},
number = {{5}},
pages = {{426--435}},
publisher = {{Elsevier}},
series = {{Pulmonary Pharmacology & Therapeutics}},
title = {{Lipid metabolites as regulators of airway smooth muscle function}},
url = {{http://dx.doi.org/10.1016/j.pupt.2008.12.003}},
doi = {{10.1016/j.pupt.2008.12.003}},
volume = {{22}},
year = {{2009}},
}