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Lipid metabolites as regulators of airway smooth muscle function

Clarke, Deborah L.; Dakshinamurti, Shyamala; Larsson Callerfelt, Anna-Karin LU ; Ward, Jane E. and Yamasaki, Akira (2009) In Pulmonary Pharmacology & Therapeutics 22(5). p.426-435
Abstract
Compelling evidence identifies airway smooth muscle (ASM) not only as a target but also a cellular source for a diverse range of mediators underlying the processes of airway narrowing and airway hyperresponsiveness in diseases such as asthma. These include the growing family of plasma membrane phospholipid-derived polyunsaturated fatty acids broadly characterised by the prostaglandins, leukotrienes, lipoxins, isoprostanes and lysophospholipids. In this review, we describe the enzymatic and nonenzymatic biosynthetic pathways of these lipid mediators and how these are influenced by drug treatment, oxidative stress and airways disease. Additionally, we outline their cognate receptors, many of which are expressed by ASM. We describe potential... (More)
Compelling evidence identifies airway smooth muscle (ASM) not only as a target but also a cellular source for a diverse range of mediators underlying the processes of airway narrowing and airway hyperresponsiveness in diseases such as asthma. These include the growing family of plasma membrane phospholipid-derived polyunsaturated fatty acids broadly characterised by the prostaglandins, leukotrienes, lipoxins, isoprostanes and lysophospholipids. In this review, we describe the enzymatic and nonenzymatic biosynthetic pathways of these lipid mediators and how these are influenced by drug treatment, oxidative stress and airways disease. Additionally, we outline their cognate receptors, many of which are expressed by ASM. We describe potential deleterious and protective roles for these lipid mediators in airway inflammatory and remodelling processes by describing their effects on diverse functions of ASM in asthma that have the potential to contribute to asthma pathogenesis and symptoms. These functions include contractile tone development cytokine and extracellular matrix production, and cellular proliferation and migration. (C) 2008 Elsevier Ltd. All rights reserved. (Less)
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author
organization
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type
Contribution to journal
publication status
published
subject
keywords
Proliferation, Contraction, Lysophospholipid, Isoprostane, Leukotriene, Airway smooth muscle, Prostanoid, Migration, Inflammation
in
Pulmonary Pharmacology & Therapeutics
volume
22
issue
5
pages
426 - 435
publisher
Elsevier
external identifiers
  • wos:000270636200011
  • scopus:69249224457
ISSN
1522-9629
DOI
10.1016/j.pupt.2008.12.003
language
English
LU publication?
yes
id
c4edf562-ad3b-482f-9551-8b7a67d86661 (old id 1507248)
date added to LUP
2009-11-20 15:15:12
date last changed
2017-03-26 03:52:31
@article{c4edf562-ad3b-482f-9551-8b7a67d86661,
  abstract     = {Compelling evidence identifies airway smooth muscle (ASM) not only as a target but also a cellular source for a diverse range of mediators underlying the processes of airway narrowing and airway hyperresponsiveness in diseases such as asthma. These include the growing family of plasma membrane phospholipid-derived polyunsaturated fatty acids broadly characterised by the prostaglandins, leukotrienes, lipoxins, isoprostanes and lysophospholipids. In this review, we describe the enzymatic and nonenzymatic biosynthetic pathways of these lipid mediators and how these are influenced by drug treatment, oxidative stress and airways disease. Additionally, we outline their cognate receptors, many of which are expressed by ASM. We describe potential deleterious and protective roles for these lipid mediators in airway inflammatory and remodelling processes by describing their effects on diverse functions of ASM in asthma that have the potential to contribute to asthma pathogenesis and symptoms. These functions include contractile tone development cytokine and extracellular matrix production, and cellular proliferation and migration. (C) 2008 Elsevier Ltd. All rights reserved.},
  author       = {Clarke, Deborah L. and Dakshinamurti, Shyamala and Larsson Callerfelt, Anna-Karin and Ward, Jane E. and Yamasaki, Akira},
  issn         = {1522-9629},
  keyword      = {Proliferation,Contraction,Lysophospholipid,Isoprostane,Leukotriene,Airway smooth muscle,Prostanoid,Migration,Inflammation},
  language     = {eng},
  number       = {5},
  pages        = {426--435},
  publisher    = {Elsevier},
  series       = {Pulmonary Pharmacology & Therapeutics},
  title        = {Lipid metabolites as regulators of airway smooth muscle function},
  url          = {http://dx.doi.org/10.1016/j.pupt.2008.12.003},
  volume       = {22},
  year         = {2009},
}