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Patterns of hematologic malignancies and solid tumors among 37,838 first-degree relatives of 13,896 patients with multiple myeloma in Sweden

Kristinsson, Sigurdur Y.; Bjorkholm, Magnus; Goldin, Lynn R.; Blimark, Cecilie; Mellqvist, Ulf-Henrik; Wahlin, Anders; Turesson, Ingemar LU and Landgren, Ola (2009) In International Journal of Cancer 125(9). p.2147-2150
Abstract
There are emerging data to suggest a role for genetic factors in the pathogenesis of multiple myeloma (MM). Based on small numbers, certain solid tumors have been reported to occur more frequently among blood relatives of patients with MM. Using population-based data, we assessed risks for hematologic malignancies, monoclonal gammopathy of undetermined significance (MGUS), and solid tumors among first-degree relatives of patients with MM. We included 13,896 patients with MM and 54,365 matched controls. Also we identified first-degree relatives of patients with MM (n = 37,838) and controls (n = 151,068). Using a marginal survival model, we estimated relative risks (RRs) and 95% confidence intervals (CIs) for hematologic and solid tumors... (More)
There are emerging data to suggest a role for genetic factors in the pathogenesis of multiple myeloma (MM). Based on small numbers, certain solid tumors have been reported to occur more frequently among blood relatives of patients with MM. Using population-based data, we assessed risks for hematologic malignancies, monoclonal gammopathy of undetermined significance (MGUS), and solid tumors among first-degree relatives of patients with MM. We included 13,896 patients with MM and 54,365 matched controls. Also we identified first-degree relatives of patients with MM (n = 37,838) and controls (n = 151,068). Using a marginal survival model, we estimated relative risks (RRs) and 95% confidence intervals (CIs) for hematologic and solid tumors among family members of patients with MM and controls as measures of familial aggregation. Compared with relatives of controls, relatives of patients with MM had an increased risk of developing MM (RR = 2.1; 95% CI 1.6-2.9), MGUS (2.1; 1.5-3.1), acute lymphoblastic leukemia (ALL) (2.1; 1.0-4.2), any solid tumor (1.1; 1.0-1.1) and bladder cancer (1.3; 1.0-1.5). No significantly increased risk was found for other hematologic or solid malignancies. Our findings support a role for a shared susceptibility (genetic, environmental or both) that predisposes to MM, MGUS, ALL and bladder cancer. (C) 2009 UICC (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
keywords
familial, bladder cancer, solid tumors, multiple myeloma, MGUS, susceptibility, aggregation
in
International Journal of Cancer
volume
125
issue
9
pages
2147 - 2150
publisher
John Wiley & Sons
external identifiers
  • wos:000270750000019
  • scopus:70249141700
ISSN
0020-7136
DOI
10.1002/ijc.24514
language
English
LU publication?
yes
id
4aa581c3-d969-463e-a7a2-15ed22113bcf (old id 1507356)
date added to LUP
2009-11-20 14:10:57
date last changed
2017-10-08 03:25:04
@article{4aa581c3-d969-463e-a7a2-15ed22113bcf,
  abstract     = {There are emerging data to suggest a role for genetic factors in the pathogenesis of multiple myeloma (MM). Based on small numbers, certain solid tumors have been reported to occur more frequently among blood relatives of patients with MM. Using population-based data, we assessed risks for hematologic malignancies, monoclonal gammopathy of undetermined significance (MGUS), and solid tumors among first-degree relatives of patients with MM. We included 13,896 patients with MM and 54,365 matched controls. Also we identified first-degree relatives of patients with MM (n = 37,838) and controls (n = 151,068). Using a marginal survival model, we estimated relative risks (RRs) and 95% confidence intervals (CIs) for hematologic and solid tumors among family members of patients with MM and controls as measures of familial aggregation. Compared with relatives of controls, relatives of patients with MM had an increased risk of developing MM (RR = 2.1; 95% CI 1.6-2.9), MGUS (2.1; 1.5-3.1), acute lymphoblastic leukemia (ALL) (2.1; 1.0-4.2), any solid tumor (1.1; 1.0-1.1) and bladder cancer (1.3; 1.0-1.5). No significantly increased risk was found for other hematologic or solid malignancies. Our findings support a role for a shared susceptibility (genetic, environmental or both) that predisposes to MM, MGUS, ALL and bladder cancer. (C) 2009 UICC},
  author       = {Kristinsson, Sigurdur Y. and Bjorkholm, Magnus and Goldin, Lynn R. and Blimark, Cecilie and Mellqvist, Ulf-Henrik and Wahlin, Anders and Turesson, Ingemar and Landgren, Ola},
  issn         = {0020-7136},
  keyword      = {familial,bladder cancer,solid tumors,multiple myeloma,MGUS,susceptibility,aggregation},
  language     = {eng},
  number       = {9},
  pages        = {2147--2150},
  publisher    = {John Wiley & Sons},
  series       = {International Journal of Cancer},
  title        = {Patterns of hematologic malignancies and solid tumors among 37,838 first-degree relatives of 13,896 patients with multiple myeloma in Sweden},
  url          = {http://dx.doi.org/10.1002/ijc.24514},
  volume       = {125},
  year         = {2009},
}