No Increased Occurrence of Ischemic Heart Disease Prior to the Onset of Rheumatoid Arthritis Results From Two Swedish Population-Based Rheumatoid Arthritis Cohorts
(2009) In Arthritis and Rheumatism 60(10). p.2861-2869- Abstract
- Objective. To investigate the relative importance of shared etiologies for rheumatoid arthritis (RA) and ischemic heart disease (IHD) in terms of the well-known increased risk of HID in patients with RA, by assessing the occurrence of IHD up until the time of the onset of the first symptoms of RA. Methods. We assessed the prevalence of a history of IHD, myocardial infarction (MI), and angina pectoris before the onset of RA symptoms in 2 large population-based case-control studies. Patients with newly diagnosed RA according to the criteria of the American College of Rheumatology were included as cases. We used data from the Swedish Early Arthritis Register study and the Swedish Epidemiologic Investigation of Rheumatoid Arthritis... (More)
- Objective. To investigate the relative importance of shared etiologies for rheumatoid arthritis (RA) and ischemic heart disease (IHD) in terms of the well-known increased risk of HID in patients with RA, by assessing the occurrence of IHD up until the time of the onset of the first symptoms of RA. Methods. We assessed the prevalence of a history of IHD, myocardial infarction (MI), and angina pectoris before the onset of RA symptoms in 2 large population-based case-control studies. Patients with newly diagnosed RA according to the criteria of the American College of Rheumatology were included as cases. We used data from the Swedish Early Arthritis Register study and the Swedish Epidemiologic Investigation of Rheumatoid Arthritis case-control study and from general population controls. Information on IHD, MI, and angina pectoris was obtained from the nationwide Hospital Discharge Register and from self reports. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) to compare the prevalence of a history of IHD/Mi/angina pectoris among patients with RA with that among population controls. Results. We could not detect any increased occurrence of IHD, MI, or angina pectoris before the onset of symptoms of RA, regardless of whether data on IHD were obtained from the Hospital Discharge Register or were self reported. As detected in the Hospital Discharge Register, the OR for IHD overall was 1.0 (95% CI 0.9-1.1), the OR for MI was 1.0 (95% CI 0.9-1.1), and the OR for angina pectoris was 1.0 (95% CI 0.9-1.2). Conclusion. Shared risk factors or susceptibilities for RA and IHD are likely to contribute less than RA-related factors to the increased occurrence of IHD in patients with manifest RA. Nonetheless, the existence of shared factors associated with longer latency until the occurrence of IHD cannot be excluded. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1507620
- author
- Holmqvist, Marie E. ; Wedren, Sara ; Jacobsson, Lennart LU ; Klareskog, Lars ; Nyberg, Fredrik ; Rantapaa-Dahlqvist, Solbritt ; Alfredsson, Lars and Askling, Johan
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Arthritis and Rheumatism
- volume
- 60
- issue
- 10
- pages
- 2861 - 2869
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- wos:000270696600003
- scopus:70349779378
- pmid:19790058
- ISSN
- 1529-0131
- DOI
- 10.1002/art.24855
- language
- English
- LU publication?
- yes
- id
- 5ff371fe-1ef2-4fb7-bc9d-ddf7ec1403bb (old id 1507620)
- date added to LUP
- 2016-04-01 12:06:58
- date last changed
- 2025-04-04 14:04:47
@article{5ff371fe-1ef2-4fb7-bc9d-ddf7ec1403bb,
abstract = {{Objective. To investigate the relative importance of shared etiologies for rheumatoid arthritis (RA) and ischemic heart disease (IHD) in terms of the well-known increased risk of HID in patients with RA, by assessing the occurrence of IHD up until the time of the onset of the first symptoms of RA. Methods. We assessed the prevalence of a history of IHD, myocardial infarction (MI), and angina pectoris before the onset of RA symptoms in 2 large population-based case-control studies. Patients with newly diagnosed RA according to the criteria of the American College of Rheumatology were included as cases. We used data from the Swedish Early Arthritis Register study and the Swedish Epidemiologic Investigation of Rheumatoid Arthritis case-control study and from general population controls. Information on IHD, MI, and angina pectoris was obtained from the nationwide Hospital Discharge Register and from self reports. We calculated odds ratios (ORs) and 95% confidence intervals (95% CIs) to compare the prevalence of a history of IHD/Mi/angina pectoris among patients with RA with that among population controls. Results. We could not detect any increased occurrence of IHD, MI, or angina pectoris before the onset of symptoms of RA, regardless of whether data on IHD were obtained from the Hospital Discharge Register or were self reported. As detected in the Hospital Discharge Register, the OR for IHD overall was 1.0 (95% CI 0.9-1.1), the OR for MI was 1.0 (95% CI 0.9-1.1), and the OR for angina pectoris was 1.0 (95% CI 0.9-1.2). Conclusion. Shared risk factors or susceptibilities for RA and IHD are likely to contribute less than RA-related factors to the increased occurrence of IHD in patients with manifest RA. Nonetheless, the existence of shared factors associated with longer latency until the occurrence of IHD cannot be excluded.}},
author = {{Holmqvist, Marie E. and Wedren, Sara and Jacobsson, Lennart and Klareskog, Lars and Nyberg, Fredrik and Rantapaa-Dahlqvist, Solbritt and Alfredsson, Lars and Askling, Johan}},
issn = {{1529-0131}},
language = {{eng}},
number = {{10}},
pages = {{2861--2869}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Arthritis and Rheumatism}},
title = {{No Increased Occurrence of Ischemic Heart Disease Prior to the Onset of Rheumatoid Arthritis Results From Two Swedish Population-Based Rheumatoid Arthritis Cohorts}},
url = {{http://dx.doi.org/10.1002/art.24855}},
doi = {{10.1002/art.24855}},
volume = {{60}},
year = {{2009}},
}