Genetic Influence on Osteoarthritis Versus Other Rheumatic Diseases
Magnusson, Karin LU ; Turkiewicz, Aleksandra LU ; Rydén, Martin LU
and Englund, Martin
LU
(2023)
In Arthritis and Rheumatology
- Abstract
Objective: We aimed to compare the genetic contribution to osteoarthritis (OA) versus other rheumatic/musculoskeletal diseases (RMDs) in the same population and to explore the role for any shared genetics between OA and other RMDs. Methods: In 59,970 Swedish twins aged 35 years or older, we estimated the heritability (the variance explained by genetic factors) of OA in peripheral joints, back and neck pain, shoulder pain (adhesive capsulitis, impingement syndrome, etc), rheumatoid arthritis, spondyloarthritis (SpA) and psoriatic arthritis, myalgia, and osteoporosis diagnosed in specialist and inpatient care. We also studied how much covariance between OA and each of the RMDs could be explained by genetics by studying phenotypic... (More)
Objective: We aimed to compare the genetic contribution to osteoarthritis (OA) versus other rheumatic/musculoskeletal diseases (RMDs) in the same population and to explore the role for any shared genetics between OA and other RMDs. Methods: In 59,970 Swedish twins aged 35 years or older, we estimated the heritability (the variance explained by genetic factors) of OA in peripheral joints, back and neck pain, shoulder pain (adhesive capsulitis, impingement syndrome, etc), rheumatoid arthritis, spondyloarthritis (SpA) and psoriatic arthritis, myalgia, and osteoporosis diagnosed in specialist and inpatient care. We also studied how much covariance between OA and each of the RMDs could be explained by genetics by studying phenotypic correlations in bivariate classical twin models. Results: Any-site OA and hip OA (50% and 64%) were among the most heritable RMDs (as compared with 23% for fibromyalgia [lowest] and 63% for SpA [highest]). The highest phenotypic correlations were between OA (any joint site) and shoulder pain in the same individual (r = 0.33, 95% confidence interval 0.31–0.35), of which 70% (95% confidence interval 52–88) could be explained by shared genetics. The phenotypic correlation between OA and back/neck pain was r = 0.25, with 25% to 75% explained by genetics. Phenotypic correlations between OA and each of the other RMDs were lower (r ~ 0.1 to r ~ 0.2), with inconclusive sources of variation. Conclusion: OA has relatively large heritability as compared with other RMDs. The coexistence of OA and shoulder pain, as well as back pain, was common and could often be explained by genetic factors. Findings imply similar etiologies of OA and several pain conditions.
(Less)
- author
- Magnusson, Karin
LU
; Turkiewicz, Aleksandra
LU
; Rydén, Martin
LU
and Englund, Martin
LU
- organization
- publishing date
- 2023
- type
- Contribution to journal
- publication status
- in press
- subject
- in
- Arthritis and Rheumatology
- publisher
- John Wiley & Sons Inc.
- external identifiers
-
- pmid:37691153
- scopus:85181247114
- ISSN
- 2326-5191
- DOI
- 10.1002/art.42696
- language
- English
- LU publication?
- yes
- id
- 151120f1-c846-4193-92fe-507c80dd881c
- date added to LUP
- 2024-01-29 14:57:28
- date last changed
- 2024-04-15 05:44:53
@article{151120f1-c846-4193-92fe-507c80dd881c,
abstract = {{<p>Objective: We aimed to compare the genetic contribution to osteoarthritis (OA) versus other rheumatic/musculoskeletal diseases (RMDs) in the same population and to explore the role for any shared genetics between OA and other RMDs. Methods: In 59,970 Swedish twins aged 35 years or older, we estimated the heritability (the variance explained by genetic factors) of OA in peripheral joints, back and neck pain, shoulder pain (adhesive capsulitis, impingement syndrome, etc), rheumatoid arthritis, spondyloarthritis (SpA) and psoriatic arthritis, myalgia, and osteoporosis diagnosed in specialist and inpatient care. We also studied how much covariance between OA and each of the RMDs could be explained by genetics by studying phenotypic correlations in bivariate classical twin models. Results: Any-site OA and hip OA (50% and 64%) were among the most heritable RMDs (as compared with 23% for fibromyalgia [lowest] and 63% for SpA [highest]). The highest phenotypic correlations were between OA (any joint site) and shoulder pain in the same individual (r = 0.33, 95% confidence interval 0.31–0.35), of which 70% (95% confidence interval 52–88) could be explained by shared genetics. The phenotypic correlation between OA and back/neck pain was r = 0.25, with 25% to 75% explained by genetics. Phenotypic correlations between OA and each of the other RMDs were lower (r ~ 0.1 to r ~ 0.2), with inconclusive sources of variation. Conclusion: OA has relatively large heritability as compared with other RMDs. The coexistence of OA and shoulder pain, as well as back pain, was common and could often be explained by genetic factors. Findings imply similar etiologies of OA and several pain conditions.</p>}},
author = {{Magnusson, Karin and Turkiewicz, Aleksandra and Rydén, Martin and Englund, Martin}},
issn = {{2326-5191}},
language = {{eng}},
publisher = {{John Wiley & Sons Inc.}},
series = {{Arthritis and Rheumatology}},
title = {{Genetic Influence on Osteoarthritis Versus Other Rheumatic Diseases}},
url = {{http://dx.doi.org/10.1002/art.42696}},
doi = {{10.1002/art.42696}},
year = {{2023}},
}