Xolair Is Effective in Allergics with a Low Serum IgE Level.
(2010) In International Archives of Allergy and Immunology 152(1). p.71-74- Abstract
- Background: Two atopic patients suffering from severe allergy difficult to handle by conventional medication were given Xolair despite an IgE level <30 kU/l. Methods: Increasing dosages were given and monitored by clinical evaluation and CD-sens to clinically relevant allergens. The patients' IgE antibody fractions were 11-14%. Results: Xolair dosages extrapolated from a recommended dose for IgE of 30-75 kU/l were adapted to the patients' IgE body pool but had very little effect. The double dose resulted in some clinical improvement and a decrease in CD-sens. However, not until the dose was doubled again did the patients become symptom free, although 1 patient needed some additional drugs but no oral steroids. CD-sens turned negative to... (More)
- Background: Two atopic patients suffering from severe allergy difficult to handle by conventional medication were given Xolair despite an IgE level <30 kU/l. Methods: Increasing dosages were given and monitored by clinical evaluation and CD-sens to clinically relevant allergens. The patients' IgE antibody fractions were 11-14%. Results: Xolair dosages extrapolated from a recommended dose for IgE of 30-75 kU/l were adapted to the patients' IgE body pool but had very little effect. The double dose resulted in some clinical improvement and a decrease in CD-sens. However, not until the dose was doubled again did the patients become symptom free, although 1 patient needed some additional drugs but no oral steroids. CD-sens turned negative to 5 of the 7 tested allergens. Conclusions: Xolair is most useful also in atopics with an IgE level <30 kU/l. The dose must be adjusted to the size of the IgE antibody fraction adding all non-cross-reacting, clinically relevant specificities. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1511534
- author
- Ankerst, Jaro
LU
; Nopp, A ; Johansson, S G O ; Adédoyin, J and Oman, H
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Archives of Allergy and Immunology
- volume
- 152
- issue
- 1
- pages
- 71 - 74
- publisher
- Karger
- external identifiers
-
- wos:000275350800009
- pmid:19940508
- scopus:70450173212
- pmid:19940508
- ISSN
- 1423-0097
- DOI
- 10.1159/000260086
- language
- English
- LU publication?
- yes
- id
- d7306ee8-8f65-485c-ac73-95a5182e4b7e (old id 1511534)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19940508?dopt=Abstract
- date added to LUP
- 2016-04-04 07:17:27
- date last changed
- 2024-10-12 13:53:15
@article{d7306ee8-8f65-485c-ac73-95a5182e4b7e, abstract = {{Background: Two atopic patients suffering from severe allergy difficult to handle by conventional medication were given Xolair despite an IgE level <30 kU/l. Methods: Increasing dosages were given and monitored by clinical evaluation and CD-sens to clinically relevant allergens. The patients' IgE antibody fractions were 11-14%. Results: Xolair dosages extrapolated from a recommended dose for IgE of 30-75 kU/l were adapted to the patients' IgE body pool but had very little effect. The double dose resulted in some clinical improvement and a decrease in CD-sens. However, not until the dose was doubled again did the patients become symptom free, although 1 patient needed some additional drugs but no oral steroids. CD-sens turned negative to 5 of the 7 tested allergens. Conclusions: Xolair is most useful also in atopics with an IgE level <30 kU/l. The dose must be adjusted to the size of the IgE antibody fraction adding all non-cross-reacting, clinically relevant specificities.}}, author = {{Ankerst, Jaro and Nopp, A and Johansson, S G O and Adédoyin, J and Oman, H}}, issn = {{1423-0097}}, language = {{eng}}, number = {{1}}, pages = {{71--74}}, publisher = {{Karger}}, series = {{International Archives of Allergy and Immunology}}, title = {{Xolair Is Effective in Allergics with a Low Serum IgE Level.}}, url = {{http://dx.doi.org/10.1159/000260086}}, doi = {{10.1159/000260086}}, volume = {{152}}, year = {{2010}}, }