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Cerebral energy metabolism and microdialysis in neurocritical care.

Nordström, Carl-Henrik LU (2010) In Child's Nervous System 26. p.465-472
Abstract
It is of obvious clinical importance to monitor cerebral metabolism-in particular, cerebral energy metabolism and indicators of cellular damage-online at the bedside. The technique of cerebral microdialysis provides the opportunity for continuous monitoring of metabolic changes in the tissue before they are reflected in peripheral blood chemistry or in systemic physiological parameters. The basic idea of microdialysis is to mimic the function of a blood capillary by positioning a thin dialysis tube in the tissue and to be used to analyze the chemical composition of the interstitial fluid. The biochemical variables used during routine monitoring were chosen to cover important aspects of cerebral energy metabolism (glucose, pyruvate and... (More)
It is of obvious clinical importance to monitor cerebral metabolism-in particular, cerebral energy metabolism and indicators of cellular damage-online at the bedside. The technique of cerebral microdialysis provides the opportunity for continuous monitoring of metabolic changes in the tissue before they are reflected in peripheral blood chemistry or in systemic physiological parameters. The basic idea of microdialysis is to mimic the function of a blood capillary by positioning a thin dialysis tube in the tissue and to be used to analyze the chemical composition of the interstitial fluid. The biochemical variables used during routine monitoring were chosen to cover important aspects of cerebral energy metabolism (glucose, pyruvate and lactate), to indicate excessive interstitial levels of excitatory transmitter substance (glutamate) and to give indications of degradation of cellular membranes (glycerol). Furthermore, pharmokinetic studies can be conducted using microdialysis. This article discusses technical and physiological aspects of microdialysis, and its clinical applications in brain injury. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Child's Nervous System
volume
26
pages
465 - 472
publisher
Springer
external identifiers
  • wos:000275537100008
  • pmid:19937248
  • scopus:77952095796
ISSN
1433-0350
DOI
10.1007/s00381-009-1035-z
language
English
LU publication?
yes
id
5105d287-8dc5-4794-a479-f42527daa8da (old id 1511562)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19937248?dopt=Abstract
date added to LUP
2009-12-07 09:34:17
date last changed
2018-05-29 12:23:00
@article{5105d287-8dc5-4794-a479-f42527daa8da,
  abstract     = {It is of obvious clinical importance to monitor cerebral metabolism-in particular, cerebral energy metabolism and indicators of cellular damage-online at the bedside. The technique of cerebral microdialysis provides the opportunity for continuous monitoring of metabolic changes in the tissue before they are reflected in peripheral blood chemistry or in systemic physiological parameters. The basic idea of microdialysis is to mimic the function of a blood capillary by positioning a thin dialysis tube in the tissue and to be used to analyze the chemical composition of the interstitial fluid. The biochemical variables used during routine monitoring were chosen to cover important aspects of cerebral energy metabolism (glucose, pyruvate and lactate), to indicate excessive interstitial levels of excitatory transmitter substance (glutamate) and to give indications of degradation of cellular membranes (glycerol). Furthermore, pharmokinetic studies can be conducted using microdialysis. This article discusses technical and physiological aspects of microdialysis, and its clinical applications in brain injury.},
  author       = {Nordström, Carl-Henrik},
  issn         = {1433-0350},
  language     = {eng},
  pages        = {465--472},
  publisher    = {Springer},
  series       = {Child's Nervous System},
  title        = {Cerebral energy metabolism and microdialysis in neurocritical care.},
  url          = {http://dx.doi.org/10.1007/s00381-009-1035-z},
  volume       = {26},
  year         = {2010},
}