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Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma.

Gunnarsson, Salina LU ; Bexell, Daniel LU ; Svensson, Andreas LU ; Siesjö, Peter LU ; Darabi, Anna LU and Bengzon, Johan LU (2010) In Journal of Neuroimmunology 218(1-2). p.140-144
Abstract
The present study reports regression of pre-established experimental rat gliomas as a result of combining peripheral immunization using interferon gamma (IFNgamma) transduced autologous tumor cells with local intratumoral delivery of interleukin 7 (IL-7) by mesenchymal stromal cells. IL-7 alone significantly decreased the tumor area and this effect was enhanced with IFNgamma immunization. A higher density of intratumoral T-cells was observed in animals receiving combined therapies compared to rats receiving either cytokine alone suggesting that the therapeutic effect is dependent on a T-cell response.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Neuroimmunology
volume
218
issue
1-2
pages
140 - 144
publisher
Elsevier
external identifiers
  • wos:000274672700021
  • pmid:19914721
  • scopus:73349125063
ISSN
1872-8421
DOI
10.1016/j.jneuroim.2009.10.017
language
English
LU publication?
yes
id
0bfc8e04-4901-4824-bd5c-c579621a5c7a (old id 1511913)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19914721?dopt=Abstract
date added to LUP
2009-12-03 15:10:24
date last changed
2018-05-29 11:50:56
@article{0bfc8e04-4901-4824-bd5c-c579621a5c7a,
  abstract     = {The present study reports regression of pre-established experimental rat gliomas as a result of combining peripheral immunization using interferon gamma (IFNgamma) transduced autologous tumor cells with local intratumoral delivery of interleukin 7 (IL-7) by mesenchymal stromal cells. IL-7 alone significantly decreased the tumor area and this effect was enhanced with IFNgamma immunization. A higher density of intratumoral T-cells was observed in animals receiving combined therapies compared to rats receiving either cytokine alone suggesting that the therapeutic effect is dependent on a T-cell response.},
  author       = {Gunnarsson, Salina and Bexell, Daniel and Svensson, Andreas and Siesjö, Peter and Darabi, Anna and Bengzon, Johan},
  issn         = {1872-8421},
  language     = {eng},
  number       = {1-2},
  pages        = {140--144},
  publisher    = {Elsevier},
  series       = {Journal of Neuroimmunology},
  title        = {Intratumoral IL-7 delivery by mesenchymal stromal cells potentiates IFNgamma-transduced tumor cell immunotherapy of experimental glioma.},
  url          = {http://dx.doi.org/10.1016/j.jneuroim.2009.10.017},
  volume       = {218},
  year         = {2010},
}