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Cdc42-mediated tubulogenesis controls cell specification.

Kesavan, Gokul LU ; Wolfhagen Sand, Fredrik LU ; Greiner, Thomas LU ; Johansson, Jenny LU ; Kobberup, Sune LU ; Wu, Xunwei; Brakebusch, Cord and Semb, Henrik LU (2009) In Cell 139(4). p.791-801
Abstract
Understanding how cells polarize and coordinate tubulogenesis during organ formation is a central question in biology. Tubulogenesis often coincides with cell-lineage specification during organ development. Hence, an elementary question is whether these two processes are independently controlled, or whether proper cell specification depends on formation of tubes. To address these fundamental questions, we have studied the functional role of Cdc42 in pancreatic tubulogenesis. We present evidence that Cdc42 is essential for tube formation, specifically for initiating microlumen formation and later for maintaining apical cell polarity. Finally, we show that Cdc42 controls cell specification non-cell-autonomously by providing the correct... (More)
Understanding how cells polarize and coordinate tubulogenesis during organ formation is a central question in biology. Tubulogenesis often coincides with cell-lineage specification during organ development. Hence, an elementary question is whether these two processes are independently controlled, or whether proper cell specification depends on formation of tubes. To address these fundamental questions, we have studied the functional role of Cdc42 in pancreatic tubulogenesis. We present evidence that Cdc42 is essential for tube formation, specifically for initiating microlumen formation and later for maintaining apical cell polarity. Finally, we show that Cdc42 controls cell specification non-cell-autonomously by providing the correct microenvironment for proper control of cell-fate choices of multipotent progenitors. For a video summary of this article, see the PaperFlick file with the Supplemental Data available online. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Cell
volume
139
issue
4
pages
791 - 801
publisher
Cell Press
external identifiers
  • wos:000271747200022
  • pmid:19914171
  • scopus:70350755882
ISSN
1097-4172
DOI
10.1016/j.cell.2009.08.049
language
English
LU publication?
yes
id
78391351-f918-49aa-a645-d294a81a81d4 (old id 1511931)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19914171?dopt=Abstract
date added to LUP
2009-12-03 15:16:07
date last changed
2017-12-03 03:46:45
@article{78391351-f918-49aa-a645-d294a81a81d4,
  abstract     = {Understanding how cells polarize and coordinate tubulogenesis during organ formation is a central question in biology. Tubulogenesis often coincides with cell-lineage specification during organ development. Hence, an elementary question is whether these two processes are independently controlled, or whether proper cell specification depends on formation of tubes. To address these fundamental questions, we have studied the functional role of Cdc42 in pancreatic tubulogenesis. We present evidence that Cdc42 is essential for tube formation, specifically for initiating microlumen formation and later for maintaining apical cell polarity. Finally, we show that Cdc42 controls cell specification non-cell-autonomously by providing the correct microenvironment for proper control of cell-fate choices of multipotent progenitors. For a video summary of this article, see the PaperFlick file with the Supplemental Data available online.},
  author       = {Kesavan, Gokul and Wolfhagen Sand, Fredrik and Greiner, Thomas and Johansson, Jenny and Kobberup, Sune and Wu, Xunwei and Brakebusch, Cord and Semb, Henrik},
  issn         = {1097-4172},
  language     = {eng},
  number       = {4},
  pages        = {791--801},
  publisher    = {Cell Press},
  series       = {Cell},
  title        = {Cdc42-mediated tubulogenesis controls cell specification.},
  url          = {http://dx.doi.org/10.1016/j.cell.2009.08.049},
  volume       = {139},
  year         = {2009},
}