Mannan-binding lectin in women with a history of recurrent vulvovaginal candidiasis.
(2010) In European Journal of Obstetrics, Gynecology, and Reproductive Biology 148(2). p.163-165- Abstract
- OBJECTIVES: To determine the serum concentration of mannan-binding lectin (MBL), a component of the innate immune system, in women with a history of recurrent vulvovaginal candidiasis (RVVC) and to correlate the result to candida-cultures, contraceptive use, if any, and to different antifungal therapies. STUDY DESIGN: Twenty-nine women with a history of RVVC were investigated. Cultures of vulvar and vaginal samples were grown on chromogenic agar. Serum levels of MBL were determined by a sandwich time-resolved immunofluorometric assay, using anti-MBL coated microtiter wells containing samples, which were washed, incubated with biotinylated anti-MBL followed by europium-labeled streptavidin and measured by time-resolved flourometry. RESULTS:... (More)
- OBJECTIVES: To determine the serum concentration of mannan-binding lectin (MBL), a component of the innate immune system, in women with a history of recurrent vulvovaginal candidiasis (RVVC) and to correlate the result to candida-cultures, contraceptive use, if any, and to different antifungal therapies. STUDY DESIGN: Twenty-nine women with a history of RVVC were investigated. Cultures of vulvar and vaginal samples were grown on chromogenic agar. Serum levels of MBL were determined by a sandwich time-resolved immunofluorometric assay, using anti-MBL coated microtiter wells containing samples, which were washed, incubated with biotinylated anti-MBL followed by europium-labeled streptavidin and measured by time-resolved flourometry. RESULTS: The median MBL level was higher in the RVVC cases than in 30 women with no history of genital candida infection who served as a comparison group (p=0.006). It was also higher in the candida-positive than in the culture-negative RVVC (p=0.02). The median concentration of MBL was also higher in hormonal contraceptive users as compared to condom-users and those using no contraceptive at all (p=0.03). CONCLUSION: The result indicates a role of MBL in RVVC and the production may correlate to vulvar/vaginal colonization by Candida, hormonal contraceptive use, and antifungal therapies. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1511977
- author
- Henic, Emir LU ; Thiel, Steffen and Mårdh, Per-Anders LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- European Journal of Obstetrics, Gynecology, and Reproductive Biology
- volume
- 148
- issue
- 2
- pages
- 163 - 165
- publisher
- Elsevier
- external identifiers
-
- wos:000274845400013
- pmid:19910100
- scopus:73749084681
- ISSN
- 0301-2115
- DOI
- 10.1016/j.ejogrb.2009.10.008
- language
- English
- LU publication?
- yes
- id
- 73377111-cb2c-4e3a-a4e0-a9ca5305c975 (old id 1511977)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19910100?dopt=Abstract
- date added to LUP
- 2016-04-01 10:42:25
- date last changed
- 2022-02-25 04:55:31
@article{73377111-cb2c-4e3a-a4e0-a9ca5305c975, abstract = {{OBJECTIVES: To determine the serum concentration of mannan-binding lectin (MBL), a component of the innate immune system, in women with a history of recurrent vulvovaginal candidiasis (RVVC) and to correlate the result to candida-cultures, contraceptive use, if any, and to different antifungal therapies. STUDY DESIGN: Twenty-nine women with a history of RVVC were investigated. Cultures of vulvar and vaginal samples were grown on chromogenic agar. Serum levels of MBL were determined by a sandwich time-resolved immunofluorometric assay, using anti-MBL coated microtiter wells containing samples, which were washed, incubated with biotinylated anti-MBL followed by europium-labeled streptavidin and measured by time-resolved flourometry. RESULTS: The median MBL level was higher in the RVVC cases than in 30 women with no history of genital candida infection who served as a comparison group (p=0.006). It was also higher in the candida-positive than in the culture-negative RVVC (p=0.02). The median concentration of MBL was also higher in hormonal contraceptive users as compared to condom-users and those using no contraceptive at all (p=0.03). CONCLUSION: The result indicates a role of MBL in RVVC and the production may correlate to vulvar/vaginal colonization by Candida, hormonal contraceptive use, and antifungal therapies.}}, author = {{Henic, Emir and Thiel, Steffen and Mårdh, Per-Anders}}, issn = {{0301-2115}}, language = {{eng}}, number = {{2}}, pages = {{163--165}}, publisher = {{Elsevier}}, series = {{European Journal of Obstetrics, Gynecology, and Reproductive Biology}}, title = {{Mannan-binding lectin in women with a history of recurrent vulvovaginal candidiasis.}}, url = {{http://dx.doi.org/10.1016/j.ejogrb.2009.10.008}}, doi = {{10.1016/j.ejogrb.2009.10.008}}, volume = {{148}}, year = {{2010}}, }