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Hedgehog, but not Odd skipped, induces segmental grooves in the Drosophila epidermis.

Mulinari, Shai LU and Häcker, Udo LU (2009) In Development 136(23). p.3875-3880
Abstract
The formation of segmental grooves during mid embryogenesis in the Drosophila epidermis depends on the specification of a single row of groove cells posteriorly adjacent to cells that express the Hedgehog signal. However, the mechanism of groove formation and the role of the parasegmental organizer, which consists of adjacent rows of hedgehog- and wingless-expressing cells, are not well understood. We report that although groove cells originate from a population of Odd skipped-expressing cells, this pair-rule transcription factor is not required for their specification. We further find that Hedgehog is sufficient to specify groove fate in cells of different origin as late as stage 10, suggesting that Hedgehog induces groove cell fate... (More)
The formation of segmental grooves during mid embryogenesis in the Drosophila epidermis depends on the specification of a single row of groove cells posteriorly adjacent to cells that express the Hedgehog signal. However, the mechanism of groove formation and the role of the parasegmental organizer, which consists of adjacent rows of hedgehog- and wingless-expressing cells, are not well understood. We report that although groove cells originate from a population of Odd skipped-expressing cells, this pair-rule transcription factor is not required for their specification. We further find that Hedgehog is sufficient to specify groove fate in cells of different origin as late as stage 10, suggesting that Hedgehog induces groove cell fate rather than maintaining a pre-established state. Wingless activity is continuously required in the posterior part of parasegments to antagonize segmental groove formation. Our data support an instructive role for the Wingless/Hedgehog organizer in cellular patterning. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Development
volume
136
issue
23
pages
3875 - 3880
publisher
Society for International Development
external identifiers
  • wos:000271665000003
  • pmid:19906854
  • scopus:70450208690
ISSN
1477-9129
DOI
10.1242/dev.040089
language
English
LU publication?
yes
id
47f40598-98da-43b7-840d-22004a862b04 (old id 1511998)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19906854?dopt=Abstract
date added to LUP
2009-12-01 09:50:31
date last changed
2017-04-23 03:36:16
@article{47f40598-98da-43b7-840d-22004a862b04,
  abstract     = {The formation of segmental grooves during mid embryogenesis in the Drosophila epidermis depends on the specification of a single row of groove cells posteriorly adjacent to cells that express the Hedgehog signal. However, the mechanism of groove formation and the role of the parasegmental organizer, which consists of adjacent rows of hedgehog- and wingless-expressing cells, are not well understood. We report that although groove cells originate from a population of Odd skipped-expressing cells, this pair-rule transcription factor is not required for their specification. We further find that Hedgehog is sufficient to specify groove fate in cells of different origin as late as stage 10, suggesting that Hedgehog induces groove cell fate rather than maintaining a pre-established state. Wingless activity is continuously required in the posterior part of parasegments to antagonize segmental groove formation. Our data support an instructive role for the Wingless/Hedgehog organizer in cellular patterning.},
  author       = {Mulinari, Shai and Häcker, Udo},
  issn         = {1477-9129},
  language     = {eng},
  number       = {23},
  pages        = {3875--3880},
  publisher    = {Society for International Development},
  series       = {Development},
  title        = {Hedgehog, but not Odd skipped, induces segmental grooves in the Drosophila epidermis.},
  url          = {http://dx.doi.org/10.1242/dev.040089},
  volume       = {136},
  year         = {2009},
}