The effects of achieving hypothermia early in a heterogeneous population of patients with cardiac arrest.
(2010) In International Journal of Cardiology 145. p.296-297- Abstract
- In a recent article Wolff et al. (2009) [1] present highly interesting results bearing on how timing of therapeutic hypothermia might affect outcome. However, some of their analyses are unadjusted for heterogeneities in the patient population, while others indicate a statistical model break-down. Moreover, the time from cardiac arrest to return of spontaneous circulation is recorded but not included as a potential covariate in the multivariate logistic regression, which is unfortunate considering that many studies have found it to be an important predictor of outcome. It is well-known that in observational studies it is important to adjust for all important covariates, not only statistically significant ones. Hence, we caution against... (More)
- In a recent article Wolff et al. (2009) [1] present highly interesting results bearing on how timing of therapeutic hypothermia might affect outcome. However, some of their analyses are unadjusted for heterogeneities in the patient population, while others indicate a statistical model break-down. Moreover, the time from cardiac arrest to return of spontaneous circulation is recorded but not included as a potential covariate in the multivariate logistic regression, which is unfortunate considering that many studies have found it to be an important predictor of outcome. It is well-known that in observational studies it is important to adjust for all important covariates, not only statistically significant ones. Hence, we caution against drawing firm conclusions from this study. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1512026
- author
- Nilsson, Fredrik ; Nielsen, Niklas LU and Höglund, Peter LU
- organization
- publishing date
- 2010
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Cardiology
- volume
- 145
- pages
- 296 - 297
- publisher
- Elsevier
- external identifiers
-
- wos:000284949900067
- pmid:19906453
- scopus:78649998203
- pmid:19906453
- ISSN
- 0167-5273
- DOI
- 10.1016/j.ijcard.2009.10.036
- language
- English
- LU publication?
- yes
- id
- 83b4559b-3a4c-4c86-a995-617fb8618f52 (old id 1512026)
- alternative location
- http://www.ncbi.nlm.nih.gov/pubmed/19906453?dopt=Abstract
- date added to LUP
- 2016-04-04 07:38:30
- date last changed
- 2022-01-29 02:27:23
@article{83b4559b-3a4c-4c86-a995-617fb8618f52,
abstract = {{In a recent article Wolff et al. (2009) [1] present highly interesting results bearing on how timing of therapeutic hypothermia might affect outcome. However, some of their analyses are unadjusted for heterogeneities in the patient population, while others indicate a statistical model break-down. Moreover, the time from cardiac arrest to return of spontaneous circulation is recorded but not included as a potential covariate in the multivariate logistic regression, which is unfortunate considering that many studies have found it to be an important predictor of outcome. It is well-known that in observational studies it is important to adjust for all important covariates, not only statistically significant ones. Hence, we caution against drawing firm conclusions from this study.}},
author = {{Nilsson, Fredrik and Nielsen, Niklas and Höglund, Peter}},
issn = {{0167-5273}},
language = {{eng}},
pages = {{296--297}},
publisher = {{Elsevier}},
series = {{International Journal of Cardiology}},
title = {{The effects of achieving hypothermia early in a heterogeneous population of patients with cardiac arrest.}},
url = {{http://dx.doi.org/10.1016/j.ijcard.2009.10.036}},
doi = {{10.1016/j.ijcard.2009.10.036}},
volume = {{145}},
year = {{2010}},
}