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The effects of achieving hypothermia early in a heterogeneous population of patients with cardiac arrest.

Nilsson, Fredrik; Nielsen, Niklas LU and Höglund, Peter LU (2010) In International Journal of Cardiology 145. p.296-297
Abstract
In a recent article Wolff et al. (2009) [1] present highly interesting results bearing on how timing of therapeutic hypothermia might affect outcome. However, some of their analyses are unadjusted for heterogeneities in the patient population, while others indicate a statistical model break-down. Moreover, the time from cardiac arrest to return of spontaneous circulation is recorded but not included as a potential covariate in the multivariate logistic regression, which is unfortunate considering that many studies have found it to be an important predictor of outcome. It is well-known that in observational studies it is important to adjust for all important covariates, not only statistically significant ones. Hence, we caution against... (More)
In a recent article Wolff et al. (2009) [1] present highly interesting results bearing on how timing of therapeutic hypothermia might affect outcome. However, some of their analyses are unadjusted for heterogeneities in the patient population, while others indicate a statistical model break-down. Moreover, the time from cardiac arrest to return of spontaneous circulation is recorded but not included as a potential covariate in the multivariate logistic regression, which is unfortunate considering that many studies have found it to be an important predictor of outcome. It is well-known that in observational studies it is important to adjust for all important covariates, not only statistically significant ones. Hence, we caution against drawing firm conclusions from this study. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Cardiology
volume
145
pages
296 - 297
publisher
Elsevier
external identifiers
  • wos:000284949900067
  • pmid:19906453
  • scopus:78649998203
ISSN
0167-5273
DOI
10.1016/j.ijcard.2009.10.036
language
English
LU publication?
yes
id
83b4559b-3a4c-4c86-a995-617fb8618f52 (old id 1512026)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19906453?dopt=Abstract
date added to LUP
2009-12-01 14:01:52
date last changed
2018-05-29 11:58:52
@article{83b4559b-3a4c-4c86-a995-617fb8618f52,
  abstract     = {In a recent article Wolff et al. (2009) [1] present highly interesting results bearing on how timing of therapeutic hypothermia might affect outcome. However, some of their analyses are unadjusted for heterogeneities in the patient population, while others indicate a statistical model break-down. Moreover, the time from cardiac arrest to return of spontaneous circulation is recorded but not included as a potential covariate in the multivariate logistic regression, which is unfortunate considering that many studies have found it to be an important predictor of outcome. It is well-known that in observational studies it is important to adjust for all important covariates, not only statistically significant ones. Hence, we caution against drawing firm conclusions from this study.},
  author       = {Nilsson, Fredrik and Nielsen, Niklas and Höglund, Peter},
  issn         = {0167-5273},
  language     = {eng},
  pages        = {296--297},
  publisher    = {Elsevier},
  series       = {International Journal of Cardiology},
  title        = {The effects of achieving hypothermia early in a heterogeneous population of patients with cardiac arrest.},
  url          = {http://dx.doi.org/10.1016/j.ijcard.2009.10.036},
  volume       = {145},
  year         = {2010},
}