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Immunochemical binding assays for detection and quantification of trace impurities in biotechnological production.

Mattiasson, Bo LU ; Teeparuksapun, Kosin LU and Hedström, Martin LU (2010) In Trends in Biotechnology 28. p.20-27
Abstract
New, highly sensitive, biosensor concepts make it possible to assay biomacromolecules at concentrations that previously were far below the limit of detection. The previous generation of assays used in quality control situations during biotechnological production was designed primarily for monitoring target molecules, which typically appeared in high concentrations. Hence, novel analytical techniques with high sensitivity should become increasingly important in meeting the demands from regulatory agencies with regard to declaring levels of impurities in biopharmaceuticals. Such techniques also open up opportunities for a range of other challenging measurements, for example, in the area of biohazards. This review describes the development of... (More)
New, highly sensitive, biosensor concepts make it possible to assay biomacromolecules at concentrations that previously were far below the limit of detection. The previous generation of assays used in quality control situations during biotechnological production was designed primarily for monitoring target molecules, which typically appeared in high concentrations. Hence, novel analytical techniques with high sensitivity should become increasingly important in meeting the demands from regulatory agencies with regard to declaring levels of impurities in biopharmaceuticals. Such techniques also open up opportunities for a range of other challenging measurements, for example, in the area of biohazards. This review describes the development of immuno-based biosensors and exemplifies these by presenting analyses of common impurities in biopharmaceutical production. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Trends in Biotechnology
volume
28
pages
20 - 27
publisher
Elsevier
external identifiers
  • wos:000273714300004
  • pmid:19896744
  • scopus:71849101052
ISSN
0167-7799
DOI
10.1016/j.tibtech.2009.10.002
language
English
LU publication?
yes
id
8a73b316-dc4e-483e-a317-562135f54dd0 (old id 1512161)
date added to LUP
2009-12-01 08:25:15
date last changed
2018-06-10 03:01:10
@article{8a73b316-dc4e-483e-a317-562135f54dd0,
  abstract     = {New, highly sensitive, biosensor concepts make it possible to assay biomacromolecules at concentrations that previously were far below the limit of detection. The previous generation of assays used in quality control situations during biotechnological production was designed primarily for monitoring target molecules, which typically appeared in high concentrations. Hence, novel analytical techniques with high sensitivity should become increasingly important in meeting the demands from regulatory agencies with regard to declaring levels of impurities in biopharmaceuticals. Such techniques also open up opportunities for a range of other challenging measurements, for example, in the area of biohazards. This review describes the development of immuno-based biosensors and exemplifies these by presenting analyses of common impurities in biopharmaceutical production.},
  author       = {Mattiasson, Bo and Teeparuksapun, Kosin and Hedström, Martin},
  issn         = {0167-7799},
  language     = {eng},
  pages        = {20--27},
  publisher    = {Elsevier},
  series       = {Trends in Biotechnology},
  title        = {Immunochemical binding assays for detection and quantification of trace impurities in biotechnological production.},
  url          = {http://dx.doi.org/10.1016/j.tibtech.2009.10.002},
  volume       = {28},
  year         = {2010},
}