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Swelling properties of cross-linked DNA gels.

Costa, Diana LU ; Miguel, M Graça and Lindman, Björn LU (2010) In Advances in Colloid and Interface Science 158. p.21-31
Abstract
This work represents our contribution to the field of physical chemistry of DNA gels, and concerns the synthesis and study of novel chemically cross-linked DNA gels. The use of covalent DNA gels is a very promising way to study DNA-cosolute interactions, as well as the dynamic behaviour of DNA and cationic compacting agents, like lipids, surfactants and polycations. Manipulating DNA in new ways, like DNA networks, allows a better understanding and characterization of DNA-cosolute complexes at the molecular level, and also allows us to follow the assembly structures of these complexes. The use of responsive polymer gels for targeted delivery of toxic and/or labile drugs has, during the past few years, shown to be a promising concept. The... (More)
This work represents our contribution to the field of physical chemistry of DNA gels, and concerns the synthesis and study of novel chemically cross-linked DNA gels. The use of covalent DNA gels is a very promising way to study DNA-cosolute interactions, as well as the dynamic behaviour of DNA and cationic compacting agents, like lipids, surfactants and polycations. Manipulating DNA in new ways, like DNA networks, allows a better understanding and characterization of DNA-cosolute complexes at the molecular level, and also allows us to follow the assembly structures of these complexes. The use of responsive polymer gels for targeted delivery of toxic and/or labile drugs has, during the past few years, shown to be a promising concept. The features found in the proposed system would find applications in a broader field of gel/drug interaction, for the development of controlled release and targeted delivery devices. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Advances in Colloid and Interface Science
volume
158
pages
21 - 31
publisher
Elsevier
external identifiers
  • wos:000279194700004
  • pmid:19896108
  • scopus:77956408418
ISSN
1873-3727
DOI
10.1016/j.cis.2009.10.002
language
English
LU publication?
yes
id
69ef6049-f4f9-4bc1-8fc8-cecf2eb2e00e (old id 1512180)
alternative location
http://www.sciencedirect.com/science/article/B6V5F-4XG3SDB-1/2/9c1ae9c74cffd3ea920e4d61f3e3eb59
date added to LUP
2009-12-01 08:31:01
date last changed
2018-05-29 12:06:15
@article{69ef6049-f4f9-4bc1-8fc8-cecf2eb2e00e,
  abstract     = {This work represents our contribution to the field of physical chemistry of DNA gels, and concerns the synthesis and study of novel chemically cross-linked DNA gels. The use of covalent DNA gels is a very promising way to study DNA-cosolute interactions, as well as the dynamic behaviour of DNA and cationic compacting agents, like lipids, surfactants and polycations. Manipulating DNA in new ways, like DNA networks, allows a better understanding and characterization of DNA-cosolute complexes at the molecular level, and also allows us to follow the assembly structures of these complexes. The use of responsive polymer gels for targeted delivery of toxic and/or labile drugs has, during the past few years, shown to be a promising concept. The features found in the proposed system would find applications in a broader field of gel/drug interaction, for the development of controlled release and targeted delivery devices.},
  author       = {Costa, Diana and Miguel, M Graça and Lindman, Björn},
  issn         = {1873-3727},
  language     = {eng},
  pages        = {21--31},
  publisher    = {Elsevier},
  series       = {Advances in Colloid and Interface Science},
  title        = {Swelling properties of cross-linked DNA gels.},
  url          = {http://dx.doi.org/10.1016/j.cis.2009.10.002},
  volume       = {158},
  year         = {2010},
}