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Wound edge microvascular blood flow: effects of negative pressure wound therapy using gauze or polyurethane foam.

Malmsjö, Malin LU ; Ingemansson, Richard LU ; Martin, Robin and Huddleston, Elizabeth (2009) In Annals of Plastic Surgery 63(6). p.676-681
Abstract
The aim of this study was to examine the effects of negative pressure wound therapy (NPWT) on wound edge microvascular blood flow, comparing different wound fillers. Wounds were created on the backs of 7 pigs. NPWT was applied, using either foam or gauze, at -50,-75, -100, -125, -150, or -175 mm Hg. Microvascular blood flow was measured in muscle tissue, subcutaneous tissue, and in the wound bed, at 0.5, 1, and 2.5 cm from the wound edge, using laser Doppler velocimetry. Similar patterns of blood flow response were observed when using foam or gauze. At 2.5 cm from the wound edge there was an increase in microvascular blood flow, while blood flow was decreased closer (0.5 cm) to the wound edge. The blood flow effects were similar at the... (More)
The aim of this study was to examine the effects of negative pressure wound therapy (NPWT) on wound edge microvascular blood flow, comparing different wound fillers. Wounds were created on the backs of 7 pigs. NPWT was applied, using either foam or gauze, at -50,-75, -100, -125, -150, or -175 mm Hg. Microvascular blood flow was measured in muscle tissue, subcutaneous tissue, and in the wound bed, at 0.5, 1, and 2.5 cm from the wound edge, using laser Doppler velocimetry. Similar patterns of blood flow response were observed when using foam or gauze. At 2.5 cm from the wound edge there was an increase in microvascular blood flow, while blood flow was decreased closer (0.5 cm) to the wound edge. The blood flow effects were similar at the different levels of negative pressure in muscle tissue, subcutaneous tissue, and in the wound bed. Altered microvascular blood flow to the wound edge may be one of the mechanisms by which NPWT facilitates healing. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Annals of Plastic Surgery
volume
63
issue
6
pages
676 - 681
publisher
Lippincott Williams & Wilkins
external identifiers
  • wos:000272316400022
  • pmid:19887926
  • scopus:74249088281
ISSN
1536-3708
DOI
10.1097/SAP.0b013e31819ae01b
language
English
LU publication?
yes
id
131725c4-03c9-4ff4-b11f-32234831d7ad (old id 1512270)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19887926?dopt=Abstract
date added to LUP
2009-12-01 11:37:31
date last changed
2017-11-19 03:32:42
@article{131725c4-03c9-4ff4-b11f-32234831d7ad,
  abstract     = {The aim of this study was to examine the effects of negative pressure wound therapy (NPWT) on wound edge microvascular blood flow, comparing different wound fillers. Wounds were created on the backs of 7 pigs. NPWT was applied, using either foam or gauze, at -50,-75, -100, -125, -150, or -175 mm Hg. Microvascular blood flow was measured in muscle tissue, subcutaneous tissue, and in the wound bed, at 0.5, 1, and 2.5 cm from the wound edge, using laser Doppler velocimetry. Similar patterns of blood flow response were observed when using foam or gauze. At 2.5 cm from the wound edge there was an increase in microvascular blood flow, while blood flow was decreased closer (0.5 cm) to the wound edge. The blood flow effects were similar at the different levels of negative pressure in muscle tissue, subcutaneous tissue, and in the wound bed. Altered microvascular blood flow to the wound edge may be one of the mechanisms by which NPWT facilitates healing.},
  author       = {Malmsjö, Malin and Ingemansson, Richard and Martin, Robin and Huddleston, Elizabeth},
  issn         = {1536-3708},
  language     = {eng},
  number       = {6},
  pages        = {676--681},
  publisher    = {Lippincott Williams & Wilkins},
  series       = {Annals of Plastic Surgery},
  title        = {Wound edge microvascular blood flow: effects of negative pressure wound therapy using gauze or polyurethane foam.},
  url          = {http://dx.doi.org/10.1097/SAP.0b013e31819ae01b},
  volume       = {63},
  year         = {2009},
}