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Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.

Dictor, Michael LU ; Ek, Sara LU orcid ; Sundberg, Maria ; Warenholt, Janina ; György, Czabafy ; Sernbo, Sandra LU ; Gustavsson, Elin LU ; Abu Al-Soud, Waleed LU ; Wadström, Torkel LU and Borrebaeck, Carl LU (2009) In Haematologica 94(11). p.1563-1568
Abstract
BACKGROUND: We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1. DESIGN AND METHODS: On hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed. RESULTS: Nuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt's lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were... (More)
BACKGROUND: We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1. DESIGN AND METHODS: On hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed. RESULTS: Nuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt's lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were negative for SOX11, as were all cases of intermediate Burkitt's lymphomas/diffuse large B-cell lymphoma, myeloma, Hodgkin's lymphomas and mature T-cell and NK/T-cell lymphomas. CONCLUSIONS: In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia. (Less)
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author
; ; ; ; ; ; ; ; and
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Haematologica
volume
94
issue
11
pages
1563 - 1568
publisher
Ferrata Storti Foundation
external identifiers
  • wos:000272165800013
  • pmid:19880779
  • scopus:70449359655
  • pmid:19880779
ISSN
1592-8721
DOI
10.3324/haematol.2009.008474
language
English
LU publication?
yes
additional info
The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Division of Medical Microbiology (013250400), Department of Immunotechnology (011029300), Pathology, (Lund) (013030000)
id
0935d020-aa63-4106-b331-49cfb0e1179e (old id 1512354)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19880779?dopt=Abstract
date added to LUP
2016-04-04 07:53:54
date last changed
2024-11-19 02:53:09
@article{0935d020-aa63-4106-b331-49cfb0e1179e,
  abstract     = {{BACKGROUND: We surveyed lymphomas to determine the range of expression of the mantle cell lymphoma-associated SOX11 transcription factor and its relation to cyclin D1. DESIGN AND METHODS: On hundred and seventy-two specimens were immunostained for the SOX11 N and C termini. Cyclin D1 was detected by immunohistochemistry and quantitative reverse transcriptase polymerase chain reaction; in situ hybridization for t(11;14) was applied when needed. RESULTS: Nuclear SOX11 was strongly expressed in most B and T-lymphoblastic leukemia/lymphomas and half of childhood Burkitt's lymphomas, but only weakly expressed in some hairy cell leukemias. Chronic lymphocytic leukemia/lymphoma, marginal zone, follicular and diffuse large B-cell lymphomas were negative for SOX11, as were all cases of intermediate Burkitt's lymphomas/diffuse large B-cell lymphoma, myeloma, Hodgkin's lymphomas and mature T-cell and NK/T-cell lymphomas. CONCLUSIONS: In addition to mantle cell lymphoma, SOX11 is strongly expressed only in lymphoblastic malignancies and Burkitt's lymphomas. Its expression is independent of cyclin D1 (except for weak expression in hairy cell leukemias) and unlikely to be due to translocations in lymphoid neoplasia.}},
  author       = {{Dictor, Michael and Ek, Sara and Sundberg, Maria and Warenholt, Janina and György, Czabafy and Sernbo, Sandra and Gustavsson, Elin and Abu Al-Soud, Waleed and Wadström, Torkel and Borrebaeck, Carl}},
  issn         = {{1592-8721}},
  language     = {{eng}},
  number       = {{11}},
  pages        = {{1563--1568}},
  publisher    = {{Ferrata Storti Foundation}},
  series       = {{Haematologica}},
  title        = {{Strong lymphoid nuclear expression of SOX11 transcription factor defines lymphoblastic neoplasms, mantle cell lymphoma and Burkitt's lymphoma.}},
  url          = {{https://lup.lub.lu.se/search/files/5156983/1516306.pdf}},
  doi          = {{10.3324/haematol.2009.008474}},
  volume       = {{94}},
  year         = {{2009}},
}