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Pulmonary intravascular blood volume changes through the cardiac cycle in healthy volunteers studied by cardiovascular magnetic resonance measurements of arterial and venous flow.

Ugander, Martin LU ; Jense, Erik and Arheden, Håkan LU (2009) In Journal of Cardiovascular Magnetic Resonance 11(1).
Abstract
BACKGROUND: This study aims to present a novel method for using cardiovascular magnetic resonance (CMR) to non-invasively quantify the variation in pulmonary blood volume throughout the cardiac cycle in humans. METHODS: 10 healthy volunteers (7 males, 3 female, age range 21-32 years) were studied. The blood flow in the pulmonary artery and all pulmonary veins was quantified during free breathing using phase contrast velocity encoded CMR. The difference in flow between the pulmonary artery and the pulmonary veins was integrated to calculate the change in pulmonary blood volume throughout the cardiac cycle. RESULTS: The stroke volumes in the pulmonary artery and the sum of the pulmonary veins were (mean +/- SEM) 103 +/- 6 ml and 95 +/- 6 ml,... (More)
BACKGROUND: This study aims to present a novel method for using cardiovascular magnetic resonance (CMR) to non-invasively quantify the variation in pulmonary blood volume throughout the cardiac cycle in humans. METHODS: 10 healthy volunteers (7 males, 3 female, age range 21-32 years) were studied. The blood flow in the pulmonary artery and all pulmonary veins was quantified during free breathing using phase contrast velocity encoded CMR. The difference in flow between the pulmonary artery and the pulmonary veins was integrated to calculate the change in pulmonary blood volume throughout the cardiac cycle. RESULTS: The stroke volumes in the pulmonary artery and the sum of the pulmonary veins were (mean +/- SEM) 103 +/- 6 ml and 95 +/- 6 ml, respectively. The pulmonary blood volume variation (PBVV) was 48 +/- 5 ml, and the PBVV expressed as percent of the pulmonary artery stroke volume was 46 +/- 3%. The maximum increase in pulmonary blood volume occurred 310 +/- 12 ms after the R-wave from the ECG (32 +/- 2% of the cardiac cycle). PBVV did not correlate to change in cross-sectional area in the pulmonary artery (R2 = 0.03, p = 0.66). CONCLUSION: It is feasible to non-invasively quantify the change in pulmonary blood volume during the cardiac cycle in humans using CMR. The average pulmonary blood volume variation in healthy volunteers was approximately 50 ml and this was approximately 50% of the stroke volume. Further studies are needed to assess the utility of the pulmonary blood volume variation as a measure for identifying cardiac and pulmonary vascular disease. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Journal of Cardiovascular Magnetic Resonance
volume
11
issue
1
publisher
BioMed Central
external identifiers
  • wos:000271528800001
  • pmid:19878570
  • scopus:77955165306
ISSN
1097-6647
DOI
10.1186/1532-429X-11-42
language
English
LU publication?
yes
id
2d4c044c-1760-42d0-a416-c9afa9e760fe (old id 1512420)
alternative location
http://www.ncbi.nlm.nih.gov/pubmed/19878570?dopt=Abstract
date added to LUP
2009-12-01 10:45:30
date last changed
2017-08-27 05:46:31
@article{2d4c044c-1760-42d0-a416-c9afa9e760fe,
  abstract     = {BACKGROUND: This study aims to present a novel method for using cardiovascular magnetic resonance (CMR) to non-invasively quantify the variation in pulmonary blood volume throughout the cardiac cycle in humans. METHODS: 10 healthy volunteers (7 males, 3 female, age range 21-32 years) were studied. The blood flow in the pulmonary artery and all pulmonary veins was quantified during free breathing using phase contrast velocity encoded CMR. The difference in flow between the pulmonary artery and the pulmonary veins was integrated to calculate the change in pulmonary blood volume throughout the cardiac cycle. RESULTS: The stroke volumes in the pulmonary artery and the sum of the pulmonary veins were (mean +/- SEM) 103 +/- 6 ml and 95 +/- 6 ml, respectively. The pulmonary blood volume variation (PBVV) was 48 +/- 5 ml, and the PBVV expressed as percent of the pulmonary artery stroke volume was 46 +/- 3%. The maximum increase in pulmonary blood volume occurred 310 +/- 12 ms after the R-wave from the ECG (32 +/- 2% of the cardiac cycle). PBVV did not correlate to change in cross-sectional area in the pulmonary artery (R2 = 0.03, p = 0.66). CONCLUSION: It is feasible to non-invasively quantify the change in pulmonary blood volume during the cardiac cycle in humans using CMR. The average pulmonary blood volume variation in healthy volunteers was approximately 50 ml and this was approximately 50% of the stroke volume. Further studies are needed to assess the utility of the pulmonary blood volume variation as a measure for identifying cardiac and pulmonary vascular disease.},
  articleno    = {42},
  author       = {Ugander, Martin and Jense, Erik and Arheden, Håkan},
  issn         = {1097-6647},
  language     = {eng},
  number       = {1},
  publisher    = {BioMed Central},
  series       = {Journal of Cardiovascular Magnetic Resonance},
  title        = {Pulmonary intravascular blood volume changes through the cardiac cycle in healthy volunteers studied by cardiovascular magnetic resonance measurements of arterial and venous flow.},
  url          = {http://dx.doi.org/10.1186/1532-429X-11-42},
  volume       = {11},
  year         = {2009},
}