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Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene

Zierhut, B; Daneva, T; Gartner, W; Brunnmaier, B; Mineva, I; Berggård, Tord LU and Wagner, L (2005) In Biochemical and Biophysical Research Communications 329(4). p.1193-1199
Abstract
We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists of 49 amino acids. Due to a frame shift, only the first 27 amino acids are identical to secretagogin. We demonstrate that this protein truncation results in complete loss of the calcium binding capacity. Setagin expression was found in considerable amounts in the pancreas whereas secretagogin and secretagogin-R22 were also found in the central nervous system and organs containing neurendocrine cells. (c) 2005 Elsevier Inc. All rights reserved.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Biochemical and Biophysical Research Communications
volume
329
issue
4
pages
1193 - 1199
publisher
Elsevier
external identifiers
  • pmid:15766553
  • wos:000227886300004
  • scopus:17644408724
ISSN
1090-2104
DOI
10.1016/j.bbrc.2005.02.093
language
English
LU publication?
yes
id
05f8c375-c177-45ed-8e14-83e7089baac6 (old id 151526)
date added to LUP
2007-06-29 15:22:36
date last changed
2017-08-13 04:29:31
@article{05f8c375-c177-45ed-8e14-83e7089baac6,
  abstract     = {We describe two new variants of the recently identified hexa-EF-hand calcium binding protein secretagogin. The first variant (secretagogin-R22) is characterized by one single amino acid exchange (Q/R) at codon 22, most likely due to RNA editing. The second variant of secretagogin (setagin) consists of 49 amino acids. Due to a frame shift, only the first 27 amino acids are identical to secretagogin. We demonstrate that this protein truncation results in complete loss of the calcium binding capacity. Setagin expression was found in considerable amounts in the pancreas whereas secretagogin and secretagogin-R22 were also found in the central nervous system and organs containing neurendocrine cells. (c) 2005 Elsevier Inc. All rights reserved.},
  author       = {Zierhut, B and Daneva, T and Gartner, W and Brunnmaier, B and Mineva, I and Berggård, Tord and Wagner, L},
  issn         = {1090-2104},
  language     = {eng},
  number       = {4},
  pages        = {1193--1199},
  publisher    = {Elsevier},
  series       = {Biochemical and Biophysical Research Communications},
  title        = {Setagin and secretagogin-R22: Posttranscriptional modification products of the secretagogin gene},
  url          = {http://dx.doi.org/10.1016/j.bbrc.2005.02.093},
  volume       = {329},
  year         = {2005},
}