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Chiral recognition of Nα-protected amino acids and derivatives in molecularly imprinted polymers.

Kempe, Maria LU and Mosbach, Klaus LU (1994) In International Journal of Peptide and Protein Research 44(6). p.603-606
Abstract
Highly crosslinked synthetic polymers, selective for various Nα-protected amino acids and derivatives, were prepared by non-covalent molecular imprinting. Methacrylic acid and ethylene glycol dimethacrylate were copolymerized in the presence of the print molecules, which were subsequently extracted from the polymers. The recognition of the polymers for the print molecules and molecules of similar structures was investigated by using the polymers as stationary phases in HPLC. The functional groups of the print molecules interact via hydrogen bonds with the positioned carboxyls of the polymer. It was shown that the Nα-protecting group, the Cα-protecting group and the amino acid side chain are also recognized by the binding sites in the... (More)
Highly crosslinked synthetic polymers, selective for various Nα-protected amino acids and derivatives, were prepared by non-covalent molecular imprinting. Methacrylic acid and ethylene glycol dimethacrylate were copolymerized in the presence of the print molecules, which were subsequently extracted from the polymers. The recognition of the polymers for the print molecules and molecules of similar structures was investigated by using the polymers as stationary phases in HPLC. The functional groups of the print molecules interact via hydrogen bonds with the positioned carboxyls of the polymer. It was shown that the Nα-protecting group, the Cα-protecting group and the amino acid side chain are also recognized by the binding sites in the polymer. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
International Journal of Peptide and Protein Research
volume
44
issue
6
pages
603 - 606
publisher
Munksgaard International Publishers
external identifiers
  • scopus:0028172858
ISSN
0367-8377
DOI
10.1111/j.1399-3011.1994.tb01150.x
language
English
LU publication?
yes
id
35c469dc-f1a1-458e-97fb-79a2c75ac899 (old id 1516066)
date added to LUP
2009-12-17 08:59:05
date last changed
2017-01-01 07:11:06
@article{35c469dc-f1a1-458e-97fb-79a2c75ac899,
  abstract     = {Highly crosslinked synthetic polymers, selective for various Nα-protected amino acids and derivatives, were prepared by non-covalent molecular imprinting. Methacrylic acid and ethylene glycol dimethacrylate were copolymerized in the presence of the print molecules, which were subsequently extracted from the polymers. The recognition of the polymers for the print molecules and molecules of similar structures was investigated by using the polymers as stationary phases in HPLC. The functional groups of the print molecules interact via hydrogen bonds with the positioned carboxyls of the polymer. It was shown that the Nα-protecting group, the Cα-protecting group and the amino acid side chain are also recognized by the binding sites in the polymer.},
  author       = {Kempe, Maria and Mosbach, Klaus},
  issn         = {0367-8377},
  language     = {eng},
  number       = {6},
  pages        = {603--606},
  publisher    = {Munksgaard International Publishers},
  series       = {International Journal of Peptide and Protein Research},
  title        = {Chiral recognition of Nα-protected amino acids and derivatives in molecularly imprinted polymers.},
  url          = {http://dx.doi.org/10.1111/j.1399-3011.1994.tb01150.x},
  volume       = {44},
  year         = {1994},
}