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Antibody mimicking polymers as chiral stationary phases in HPLC

Kempe, Maria LU (1996) In Analytical Chemistry 68(11). p.1948-1953
Abstract
Antibody-mimicking synthetic polymers, selective for various optically active amino acid derivatives and peptides, were prepared by noncovalent molecular imprinting. A novel approach, in which the branched, trifunctional cross-linkers pentaerythritol triacrylate and 2,2-bis(hydroxymethyl)butanol trimethacrylate were copolymerized with methacrylic acid, is described. The polymers were subsequently applied as chiral stationary phases in high-performance liquid chromatography. They were superior to previously reported noncovalent molecularly imprinted polymers used for chiral separations in that they showed considerably higher load capacity, increased selectivity, and better resolving capability.
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Analytical Chemistry
volume
68
issue
11
pages
1948 - 1953
publisher
The American Chemical Society
external identifiers
  • scopus:0030153492
ISSN
1520-6882
DOI
10.1021/ac9512160
language
English
LU publication?
yes
id
6a39efc1-d951-4edf-a59e-1efacfe1890b (old id 1516091)
date added to LUP
2009-12-17 09:31:14
date last changed
2017-06-04 03:46:28
@article{6a39efc1-d951-4edf-a59e-1efacfe1890b,
  abstract     = {Antibody-mimicking synthetic polymers, selective for various optically active amino acid derivatives and peptides, were prepared by noncovalent molecular imprinting. A novel approach, in which the branched, trifunctional cross-linkers pentaerythritol triacrylate and 2,2-bis(hydroxymethyl)butanol trimethacrylate were copolymerized with methacrylic acid, is described. The polymers were subsequently applied as chiral stationary phases in high-performance liquid chromatography. They were superior to previously reported noncovalent molecularly imprinted polymers used for chiral separations in that they showed considerably higher load capacity, increased selectivity, and better resolving capability.},
  author       = {Kempe, Maria},
  issn         = {1520-6882},
  language     = {eng},
  number       = {11},
  pages        = {1948--1953},
  publisher    = {The American Chemical Society},
  series       = {Analytical Chemistry},
  title        = {Antibody mimicking polymers as chiral stationary phases in HPLC},
  url          = {http://dx.doi.org/10.1021/ac9512160},
  volume       = {68},
  year         = {1996},
}