Poly(ethylene glycol)-containing supports for solid-phase synthesis of peptides and combinatorial organic libraries.
(1997) 680. p.239-264- Abstract
- The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis, performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating PEG into supports for solid-phase synthesis represents a successful approach to alleviating such problems. This chapter reviews the preparation of families of poly(ethylene glycol)-polystyrene (PEG-PS)graft as well as (highly) Cross-Linked Ethoxylate Acrylate Resin (CLEAR) supports developed in our laboratories, and demonstrates their applications to the... (More)
- The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis, performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating PEG into supports for solid-phase synthesis represents a successful approach to alleviating such problems. This chapter reviews the preparation of families of poly(ethylene glycol)-polystyrene (PEG-PS)graft as well as (highly) Cross-Linked Ethoxylate Acrylate Resin (CLEAR) supports developed in our laboratories, and demonstrates their applications to the syntheses of a wide range of targets in connection with numerous research objectives. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1516124
- author
- Barany, George ; Albericio, Fernando ; Kates, Steven and Kempe, Maria LU
- organization
- publishing date
- 1997
- type
- Chapter in Book/Report/Conference proceeding
- publication status
- published
- subject
- categories
- Popular Science
- host publication
- Poly(ethylene glycol): Chemistry and Biological Applications, ACS Symp. Series
- editor
- Harris, J.M. and Zalipsky, S.
- volume
- 680
- pages
- 239 - 264
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- scopus:0347800797
- ISBN
- 9780841235373
- DOI
- 10.1021/bk-1997-0680.ch017
- language
- English
- LU publication?
- yes
- id
- b5aff72d-47f5-4281-b59a-d5b2d281d730 (old id 1516124)
- date added to LUP
- 2016-04-04 11:32:07
- date last changed
- 2022-02-06 07:25:59
@inbook{b5aff72d-47f5-4281-b59a-d5b2d281d730, abstract = {{The choice of a polymeric support is a key factor for the success of solid-phase methods for syntheses of organic compounds and biomolecules such as peptides and oligonucleotides. Classical Merrifield solid-phase peptide synthesis, performed on low cross-linked hydrophobic polystyrene (PS) beads, sometimes suffers from sequence-dependent coupling difficulties. The concept of incorporating PEG into supports for solid-phase synthesis represents a successful approach to alleviating such problems. This chapter reviews the preparation of families of poly(ethylene glycol)-polystyrene (PEG-PS)graft as well as (highly) Cross-Linked Ethoxylate Acrylate Resin (CLEAR) supports developed in our laboratories, and demonstrates their applications to the syntheses of a wide range of targets in connection with numerous research objectives.}}, author = {{Barany, George and Albericio, Fernando and Kates, Steven and Kempe, Maria}}, booktitle = {{Poly(ethylene glycol): Chemistry and Biological Applications, ACS Symp. Series}}, editor = {{Harris, J.M. and Zalipsky, S.}}, isbn = {{9780841235373}}, language = {{eng}}, pages = {{239--264}}, publisher = {{The American Chemical Society (ACS)}}, title = {{Poly(ethylene glycol)-containing supports for solid-phase synthesis of peptides and combinatorial organic libraries.}}, url = {{http://dx.doi.org/10.1021/bk-1997-0680.ch017}}, doi = {{10.1021/bk-1997-0680.ch017}}, volume = {{680}}, year = {{1997}}, }