XEDS-mapping for explaining release patterns from single pellets
(2005) In International Journal of Pharmaceutics 290(1-2). p.109-120- Abstract
- A common way to formulate controlled-release (CR) pharmaceuticals is to coat pellets of active substance with a polymer film, decrease the size of the pellets and distribute them as multiple-unit dosages in capsules. To increase the understanding of the release mechanism, the pellet shape and surface structure of pellets, before and after release in microtitre plates, have been studied by scanning electron microscope and X-ray energy-dispersive spectrometry. By performing these studies we associate release profiles during the first few hours to the microscopic structure. Pellets were divided into three classes (spherical pellets, dumbbell shaped pellets and twin-pellets) according to pellet form. Cases of burst release occurred for all... (More)
- A common way to formulate controlled-release (CR) pharmaceuticals is to coat pellets of active substance with a polymer film, decrease the size of the pellets and distribute them as multiple-unit dosages in capsules. To increase the understanding of the release mechanism, the pellet shape and surface structure of pellets, before and after release in microtitre plates, have been studied by scanning electron microscope and X-ray energy-dispersive spectrometry. By performing these studies we associate release profiles during the first few hours to the microscopic structure. Pellets were divided into three classes (spherical pellets, dumbbell shaped pellets and twin-pellets) according to pellet form. Cases of burst release occurred for all three shape classes due to "open-window-defects" at the surface. Areas of thinner polymer film in the neck-region of dumbbell shaped pellets broaden the range of intermediate release rates for this pellet shape. The surface of twin pellets and dumbbell shaped pellets showed more defects, which increases the release rates in comparison to spherical pellets. All pellets with high release rates revealed ruptures in the polymer film, whereas only small cracks could be traced for pellets with slow release rates. The information gained is necessary for the development of future formulations and mathematical modelling of release patterns. The pharmaceutical used as model was remoxipride coated with a polymer film of ethyl cellulose and 10 wt.% triethyl citrate. (C) 2004 Elsevier B.V. All rights reserved. (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/151754
- author
- Nevsten, Pernilla LU ; Borgquist, Per LU ; Axelsson, Anders LU and Wallenberg, Reine LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- International Journal of Pharmaceutics
- volume
- 290
- issue
- 1-2
- pages
- 109 - 120
- publisher
- Elsevier
- external identifiers
-
- wos:000226985500012
- pmid:15664136
- scopus:12344267897
- pmid:15664136
- ISSN
- 1873-3476
- DOI
- 10.1016/j.ijpharm.2004.11.022
- language
- English
- LU publication?
- yes
- additional info
- The information about affiliations in this record was updated in December 2015. The record was previously connected to the following departments: Polymer and Materials Chemistry (LTH) (011001041), Chemical Engineering (011001014)
- id
- e89298e3-0c68-4356-a8ee-0ceb0660cd5a (old id 151754)
- date added to LUP
- 2016-04-01 12:09:40
- date last changed
- 2023-09-01 21:27:53
@article{e89298e3-0c68-4356-a8ee-0ceb0660cd5a,
abstract = {{A common way to formulate controlled-release (CR) pharmaceuticals is to coat pellets of active substance with a polymer film, decrease the size of the pellets and distribute them as multiple-unit dosages in capsules. To increase the understanding of the release mechanism, the pellet shape and surface structure of pellets, before and after release in microtitre plates, have been studied by scanning electron microscope and X-ray energy-dispersive spectrometry. By performing these studies we associate release profiles during the first few hours to the microscopic structure. Pellets were divided into three classes (spherical pellets, dumbbell shaped pellets and twin-pellets) according to pellet form. Cases of burst release occurred for all three shape classes due to "open-window-defects" at the surface. Areas of thinner polymer film in the neck-region of dumbbell shaped pellets broaden the range of intermediate release rates for this pellet shape. The surface of twin pellets and dumbbell shaped pellets showed more defects, which increases the release rates in comparison to spherical pellets. All pellets with high release rates revealed ruptures in the polymer film, whereas only small cracks could be traced for pellets with slow release rates. The information gained is necessary for the development of future formulations and mathematical modelling of release patterns. The pharmaceutical used as model was remoxipride coated with a polymer film of ethyl cellulose and 10 wt.% triethyl citrate. (C) 2004 Elsevier B.V. All rights reserved.}},
author = {{Nevsten, Pernilla and Borgquist, Per and Axelsson, Anders and Wallenberg, Reine}},
issn = {{1873-3476}},
language = {{eng}},
number = {{1-2}},
pages = {{109--120}},
publisher = {{Elsevier}},
series = {{International Journal of Pharmaceutics}},
title = {{XEDS-mapping for explaining release patterns from single pellets}},
url = {{http://dx.doi.org/10.1016/j.ijpharm.2004.11.022}},
doi = {{10.1016/j.ijpharm.2004.11.022}},
volume = {{290}},
year = {{2005}},
}