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Nanosphere induced gene expression in human dendritic cells

Matsusaki, M; Larsson, Kristina LU ; Akagi, T; Lindstedt, Malin LU ; Akashi, M and Borrebaeck, Carl LU (2005) In Nano Letters 5(11). p.2168-2173
Abstract
The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Nano Letters
volume
5
issue
11
pages
2168 - 2173
publisher
The American Chemical Society
external identifiers
  • pmid:16277447
  • wos:000233481700011
  • scopus:28144450800
ISSN
1530-6992
DOI
10.1021/nl050541s
language
English
LU publication?
yes
id
a0efaf25-b35e-4f46-a431-b255841e4a51 (old id 152110)
date added to LUP
2007-07-09 11:59:37
date last changed
2017-08-20 04:33:23
@article{a0efaf25-b35e-4f46-a431-b255841e4a51,
  abstract     = {The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.},
  author       = {Matsusaki, M and Larsson, Kristina and Akagi, T and Lindstedt, Malin and Akashi, M and Borrebaeck, Carl},
  issn         = {1530-6992},
  language     = {eng},
  number       = {11},
  pages        = {2168--2173},
  publisher    = {The American Chemical Society},
  series       = {Nano Letters},
  title        = {Nanosphere induced gene expression in human dendritic cells},
  url          = {http://dx.doi.org/10.1021/nl050541s},
  volume       = {5},
  year         = {2005},
}