Nanosphere induced gene expression in human dendritic cells
(2005) In Nano Letters 5(11). p.2168-2173- Abstract
- The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/152110
- author
- Matsusaki, M ; Larsson, Kristina LU ; Akagi, T ; Lindstedt, Malin LU ; Akashi, M and Borrebaeck, Carl LU
- organization
- publishing date
- 2005
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Nano Letters
- volume
- 5
- issue
- 11
- pages
- 2168 - 2173
- publisher
- The American Chemical Society (ACS)
- external identifiers
-
- pmid:16277447
- wos:000233481700011
- scopus:28144450800
- pmid:16277447
- ISSN
- 1530-6992
- DOI
- 10.1021/nl050541s
- language
- English
- LU publication?
- yes
- id
- a0efaf25-b35e-4f46-a431-b255841e4a51 (old id 152110)
- date added to LUP
- 2016-04-01 17:05:45
- date last changed
- 2022-04-15 17:11:08
@article{a0efaf25-b35e-4f46-a431-b255841e4a51, abstract = {{The molecular mechanisms of nanosphere-induced mucosal immunization are important to decipher, since this can form the basis for novel approaches in, e.g., nasal vaccination. In this study, we have investigated the effect of nanospheres as antigen carriers on immature human dendritic cells. The results clearly indicate that tetanus toxoid immobilized nanospheres have a direct effect on human monocyte derived dendritic cells and induce a specific transcriptional profile involving genes crucial for phagocytosis and a protective immune response.}}, author = {{Matsusaki, M and Larsson, Kristina and Akagi, T and Lindstedt, Malin and Akashi, M and Borrebaeck, Carl}}, issn = {{1530-6992}}, language = {{eng}}, number = {{11}}, pages = {{2168--2173}}, publisher = {{The American Chemical Society (ACS)}}, series = {{Nano Letters}}, title = {{Nanosphere induced gene expression in human dendritic cells}}, url = {{http://dx.doi.org/10.1021/nl050541s}}, doi = {{10.1021/nl050541s}}, volume = {{5}}, year = {{2005}}, }