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High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma

Bjorck, E; Ek, Sara LU ; Landgren, O; Jerkeman, Mats LU ; Ehinger, Mats LU ; Bjorkholm, M; Borrebaeck, Carl LU ; Porwit-MacDonald, A and Nordenskjold, M (2005) In Blood 105(7). p.2908-2915
Abstract
Substantial research has been dedicated to the study of the relationship between genetic mechanisms regulating cell functions in tumors and how those tumors respond to various treatment regimens. Because these mechanisms are still not well understood, we have chosen to study the genetic makeup of 57 tumor samples from patients with follicular lymphoma (FL). Our goal was to develop a prognostic tool, which can be used as an aid in determining FL patients with tumors genetically predisposed to a successful treatment with the CHOP (cyclophosphamide, vincristine, doxorubicin, prednisone) regimen. To select relevant genes, high-density oligonucleotide arrays were used. There were 14 genes highly expressed in FL patients that responded well to... (More)
Substantial research has been dedicated to the study of the relationship between genetic mechanisms regulating cell functions in tumors and how those tumors respond to various treatment regimens. Because these mechanisms are still not well understood, we have chosen to study the genetic makeup of 57 tumor samples from patients with follicular lymphoma (FL). Our goal was to develop a prognostic tool, which can be used as an aid in determining FL patients with tumors genetically predisposed to a successful treatment with the CHOP (cyclophosphamide, vincristine, doxorubicin, prednisone) regimen. To select relevant genes, high-density oligonucleotide arrays were used. There were 14 genes highly expressed in FL patients that responded well to CHOP chemotherapy, and 11 of these were involved in G(2)/M transition of the cell cycle, in mitosis, or in DNA modulation. A high expression of CCNB1 (cyclin B1), CDC2, CDKN3A, CKS1B, ANP32E, and KIAA0101, but not of the proliferation-related antigen Ki-67, was associated with better survival rate in a univariate analysis. CCNB1 expression had an independent prognostic value when included in a multivariate analysis together with the 5 parameters of the follicular lymphoma international prognostic index. (Less)
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author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Blood
volume
105
issue
7
pages
2908 - 2915
publisher
American Society of Hematology
external identifiers
  • wos:000228042900049
  • pmid:15576476
  • scopus:15944429985
ISSN
1528-0020
DOI
10.1182/blood-2004-07-2721
language
English
LU publication?
yes
id
d14d11d7-5ccb-42ce-819c-167f20b44c7e (old id 152144)
date added to LUP
2007-06-27 11:10:21
date last changed
2017-10-08 03:26:46
@article{d14d11d7-5ccb-42ce-819c-167f20b44c7e,
  abstract     = {Substantial research has been dedicated to the study of the relationship between genetic mechanisms regulating cell functions in tumors and how those tumors respond to various treatment regimens. Because these mechanisms are still not well understood, we have chosen to study the genetic makeup of 57 tumor samples from patients with follicular lymphoma (FL). Our goal was to develop a prognostic tool, which can be used as an aid in determining FL patients with tumors genetically predisposed to a successful treatment with the CHOP (cyclophosphamide, vincristine, doxorubicin, prednisone) regimen. To select relevant genes, high-density oligonucleotide arrays were used. There were 14 genes highly expressed in FL patients that responded well to CHOP chemotherapy, and 11 of these were involved in G(2)/M transition of the cell cycle, in mitosis, or in DNA modulation. A high expression of CCNB1 (cyclin B1), CDC2, CDKN3A, CKS1B, ANP32E, and KIAA0101, but not of the proliferation-related antigen Ki-67, was associated with better survival rate in a univariate analysis. CCNB1 expression had an independent prognostic value when included in a multivariate analysis together with the 5 parameters of the follicular lymphoma international prognostic index.},
  author       = {Bjorck, E and Ek, Sara and Landgren, O and Jerkeman, Mats and Ehinger, Mats and Bjorkholm, M and Borrebaeck, Carl and Porwit-MacDonald, A and Nordenskjold, M},
  issn         = {1528-0020},
  language     = {eng},
  number       = {7},
  pages        = {2908--2915},
  publisher    = {American Society of Hematology},
  series       = {Blood},
  title        = {High expression of cyclin B1 predicts a favorable outcome in patients with follicular lymphoma},
  url          = {http://dx.doi.org/10.1182/blood-2004-07-2721},
  volume       = {105},
  year         = {2005},
}