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Modern mRNA proofreading and repair: Clues that the Last Universal Common Ancestor possessed an RNA genome?

Poole, A M and Logan, Derek LU (2005) In Molecular Biology and Evolution 22(6). p.1444-1455
Abstract
RNA repair has now been demonstrated to be a genuine biological process and appears to be present in all three domains of life. In this article, we consider what this might mean for the transition from an early RNA-dominated world to modem cells possessing genetically encoded proteins and DNA. There are significant gaps in our understanding of how the modem protein-DNA world could have evolved from a simpler system, and it is currently uncertain whether DNA genomes evolved once or twice. Against this backdrop, the discovery of RNA repair in modem cells is timely food for thought and brings us conceptually one step closer to understanding how RNA genomes were replaced by DNA genomes. We have examined the available literature on multisubunit... (More)
RNA repair has now been demonstrated to be a genuine biological process and appears to be present in all three domains of life. In this article, we consider what this might mean for the transition from an early RNA-dominated world to modem cells possessing genetically encoded proteins and DNA. There are significant gaps in our understanding of how the modem protein-DNA world could have evolved from a simpler system, and it is currently uncertain whether DNA genomes evolved once or twice. Against this backdrop, the discovery of RNA repair in modem cells is timely food for thought and brings us conceptually one step closer to understanding how RNA genomes were replaced by DNA genomes. We have examined the available literature on multisubunit RNA polymerase structure and function and conclude that a strong case can be made that the Last Universal Common Ancestor (LUCA) possessed a repair-competent RNA polymerase, which would have been capable of acting on an RNA genome. However, while this]ends credibility to the proposal that the LUCA had an RNA genome, the alternative, that LUCA had a DNA genome, cannot be completely ruled out. (Less)
Please use this url to cite or link to this publication:
author
organization
publishing date
type
Contribution to journal
publication status
published
subject
in
Molecular Biology and Evolution
volume
22
issue
6
pages
1444 - 1455
publisher
Oxford University Press
external identifiers
  • pmid:15774424
  • wos:000229279100009
  • scopus:19544385261
ISSN
0737-4038
DOI
10.1093/molbev/msi132
language
English
LU publication?
yes
id
154a24f0-bfcb-439f-b154-aa177f652369 (old id 152252)
date added to LUP
2007-07-09 16:15:48
date last changed
2017-09-17 04:57:30
@article{154a24f0-bfcb-439f-b154-aa177f652369,
  abstract     = {RNA repair has now been demonstrated to be a genuine biological process and appears to be present in all three domains of life. In this article, we consider what this might mean for the transition from an early RNA-dominated world to modem cells possessing genetically encoded proteins and DNA. There are significant gaps in our understanding of how the modem protein-DNA world could have evolved from a simpler system, and it is currently uncertain whether DNA genomes evolved once or twice. Against this backdrop, the discovery of RNA repair in modem cells is timely food for thought and brings us conceptually one step closer to understanding how RNA genomes were replaced by DNA genomes. We have examined the available literature on multisubunit RNA polymerase structure and function and conclude that a strong case can be made that the Last Universal Common Ancestor (LUCA) possessed a repair-competent RNA polymerase, which would have been capable of acting on an RNA genome. However, while this]ends credibility to the proposal that the LUCA had an RNA genome, the alternative, that LUCA had a DNA genome, cannot be completely ruled out.},
  author       = {Poole, A M and Logan, Derek},
  issn         = {0737-4038},
  language     = {eng},
  number       = {6},
  pages        = {1444--1455},
  publisher    = {Oxford University Press},
  series       = {Molecular Biology and Evolution},
  title        = {Modern mRNA proofreading and repair: Clues that the Last Universal Common Ancestor possessed an RNA genome?},
  url          = {http://dx.doi.org/10.1093/molbev/msi132},
  volume       = {22},
  year         = {2005},
}