Kolitcancer - mer myt än verklighet?
(2009) In Läkartidningen 106(45). p.3000-3002- Abstract
- Patients with ulcerative colitis (UC) and Crohn´s colitis are at increased of developing colorectal cancer (CRC). However, recent studies suggest that the risk is now less than previously thought. Well established risk factors include extent and duration of disease, primary sclerosing cholangitis (PSC) and a family history of CRC. Recently inflammation (both microscopic and macroscopic) has been shown to represent an important independent risk factor for CRC development. Thus one likely explanation for the decreased risk of CRC observed in UC patients is the use of agents that inhibit the inflammatory process, particularly 5-ASA. Ursodeoxycholic acid has been found to be chemopreventive in UC patients with PSC. Evidence from case series... (More)
- Patients with ulcerative colitis (UC) and Crohn´s colitis are at increased of developing colorectal cancer (CRC). However, recent studies suggest that the risk is now less than previously thought. Well established risk factors include extent and duration of disease, primary sclerosing cholangitis (PSC) and a family history of CRC. Recently inflammation (both microscopic and macroscopic) has been shown to represent an important independent risk factor for CRC development. Thus one likely explanation for the decreased risk of CRC observed in UC patients is the use of agents that inhibit the inflammatory process, particularly 5-ASA. Ursodeoxycholic acid has been found to be chemopreventive in UC patients with PSC. Evidence from case series and case-control studies suggest that surveillance colonoscopy also reduces the risk of CRC. Prospective randomized controlled trials will never be done because of ethical and logistical concerns. Thus, in the absence of these studies, our knowledge will have to rely on biologic and observational studies (Less)
Please use this url to cite or link to this publication:
https://lup.lub.lu.se/record/1523712
- author
- Hertervig, Erik LU ; Befrits, Ragnar ; Ekbom, Anders ; Karlén, Per ; Lindberg, Jan ; Löfberg, Robert ; Rutegård, Jörgen ; Sjöqvist, Urban and Ost, Ake
- organization
- publishing date
- 2009
- type
- Contribution to journal
- publication status
- published
- subject
- in
- Läkartidningen
- volume
- 106
- issue
- 45
- pages
- 3000 - 3002
- publisher
- Swedish Medical Association
- external identifiers
-
- pmid:19998826
- scopus:70350635182
- ISSN
- 0023-7205
- language
- Swedish
- LU publication?
- yes
- id
- 23f64b75-6103-4917-9f9b-304e28a8da7c (old id 1523712)
- alternative location
- http://ltarkiv.lakartidningen.se/artNo37242
- http://www.ncbi.nlm.nih.gov/pubmed/19998826?dopt=Abstract
- date added to LUP
- 2016-04-04 09:05:00
- date last changed
- 2024-01-12 08:47:36
@article{23f64b75-6103-4917-9f9b-304e28a8da7c, abstract = {{Patients with ulcerative colitis (UC) and Crohn´s colitis are at increased of developing colorectal cancer (CRC). However, recent studies suggest that the risk is now less than previously thought. Well established risk factors include extent and duration of disease, primary sclerosing cholangitis (PSC) and a family history of CRC. Recently inflammation (both microscopic and macroscopic) has been shown to represent an important independent risk factor for CRC development. Thus one likely explanation for the decreased risk of CRC observed in UC patients is the use of agents that inhibit the inflammatory process, particularly 5-ASA. Ursodeoxycholic acid has been found to be chemopreventive in UC patients with PSC. Evidence from case series and case-control studies suggest that surveillance colonoscopy also reduces the risk of CRC. Prospective randomized controlled trials will never be done because of ethical and logistical concerns. Thus, in the absence of these studies, our knowledge will have to rely on biologic and observational studies}}, author = {{Hertervig, Erik and Befrits, Ragnar and Ekbom, Anders and Karlén, Per and Lindberg, Jan and Löfberg, Robert and Rutegård, Jörgen and Sjöqvist, Urban and Ost, Ake}}, issn = {{0023-7205}}, language = {{swe}}, number = {{45}}, pages = {{3000--3002}}, publisher = {{Swedish Medical Association}}, series = {{Läkartidningen}}, title = {{Kolitcancer - mer myt än verklighet?}}, url = {{http://ltarkiv.lakartidningen.se/artNo37242}}, volume = {{106}}, year = {{2009}}, }