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Porogen formulations for obtaining molecularly imprinted polymers with optimized binding properties

Schmidt, Ronald LU ; Belmont, Anne-Sophie LU and Haupt, Karsten Olaf LU (2005) In Analytica Chimica Acta 542(1). p.118-124
Abstract
This paper examines the formulation of new porogenic mixtures used to prepare molecularly imprinted polymers (MIPs) in both thin film and bulk monolith formats. Films were cast by using spin coating to spread a pre-polymerization mixture onto a substrate, and rapid curing of the films was achieved with UV photolysis. The use of a low volatility solvent in combination with a linear polymer porogen resulted in a porous morphology and a 60-fold enhancement in the binding capacity, relative to a non-porous film prepared with a highly volatile solvent and in the absence of the polymer porogen. The opposite effect was seen in MIN that were prepared in the traditional bulk monolith format, for which the binding efficiency of the MIP decreased... (More)
This paper examines the formulation of new porogenic mixtures used to prepare molecularly imprinted polymers (MIPs) in both thin film and bulk monolith formats. Films were cast by using spin coating to spread a pre-polymerization mixture onto a substrate, and rapid curing of the films was achieved with UV photolysis. The use of a low volatility solvent in combination with a linear polymer porogen resulted in a porous morphology and a 60-fold enhancement in the binding capacity, relative to a non-porous film prepared with a highly volatile solvent and in the absence of the polymer porogen. The opposite effect was seen in MIN that were prepared in the traditional bulk monolith format, for which the binding efficiency of the MIP decreased monotonically with the concentration of the linear polymer porogen. Furthermore, bulk ME's that were prepared in the presence of linear polymer porogens exhibited significantly decreased specific surface areas (from 620 to 8 m(2)/g for samples prepared with pure solvent and 50% polymer porogen, respectively). Despite the change in binding capacity and morphology, the selectivity of the bulk MIN remained unaffected by the presence of the polymer porogens (approximately 50% chiral selectivity for all bulk MIN considered). This difference in behavior of the two systems was attributed to the large difference in the kinetics of polymerization. (c) 2005 Elsevier B.V. All rights reserved. (Less)
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organization
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type
Contribution to journal
publication status
published
subject
in
Analytica Chimica Acta
volume
542
issue
1
pages
118 - 124
publisher
Elsevier
external identifiers
  • wos:000229719200018
  • scopus:20344363391
ISSN
1873-4324
DOI
10.1016/j.aca.2005.03.064
language
English
LU publication?
yes
id
58d80f87-6f2d-495c-8428-5d1678292778 (old id 152628)
date added to LUP
2007-07-16 11:33:22
date last changed
2017-08-06 04:43:19
@article{58d80f87-6f2d-495c-8428-5d1678292778,
  abstract     = {This paper examines the formulation of new porogenic mixtures used to prepare molecularly imprinted polymers (MIPs) in both thin film and bulk monolith formats. Films were cast by using spin coating to spread a pre-polymerization mixture onto a substrate, and rapid curing of the films was achieved with UV photolysis. The use of a low volatility solvent in combination with a linear polymer porogen resulted in a porous morphology and a 60-fold enhancement in the binding capacity, relative to a non-porous film prepared with a highly volatile solvent and in the absence of the polymer porogen. The opposite effect was seen in MIN that were prepared in the traditional bulk monolith format, for which the binding efficiency of the MIP decreased monotonically with the concentration of the linear polymer porogen. Furthermore, bulk ME's that were prepared in the presence of linear polymer porogens exhibited significantly decreased specific surface areas (from 620 to 8 m(2)/g for samples prepared with pure solvent and 50% polymer porogen, respectively). Despite the change in binding capacity and morphology, the selectivity of the bulk MIN remained unaffected by the presence of the polymer porogens (approximately 50% chiral selectivity for all bulk MIN considered). This difference in behavior of the two systems was attributed to the large difference in the kinetics of polymerization. (c) 2005 Elsevier B.V. All rights reserved.},
  author       = {Schmidt, Ronald and Belmont, Anne-Sophie and Haupt, Karsten Olaf},
  issn         = {1873-4324},
  language     = {eng},
  number       = {1},
  pages        = {118--124},
  publisher    = {Elsevier},
  series       = {Analytica Chimica Acta},
  title        = {Porogen formulations for obtaining molecularly imprinted polymers with optimized binding properties},
  url          = {http://dx.doi.org/10.1016/j.aca.2005.03.064},
  volume       = {542},
  year         = {2005},
}